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Uronate isomerase (EC 5.3.1.12; URI) catalyzes uronate sugar interconversion, a key step in bacterial metabolism, yet its reaction mechanism remains poorly understood. This study delineates the detailed mechanism for the isomerization of d-glucuronate to d-fructuronate catalyzed by a Zn2+-dependent URI enzyme (from Bacillus halodurans). Using quantum mechanical (QM) cluster calculations, three mec

Successful translation requires multiple protein factors with diverse specific activities. Initiation of translation is regarded as the most tightly regulated step of this process, controlled by numerous factors. Among these is the eukaryotic initiation factor 4F (eIF4F), a protein complex composed of three subunits: the cap-binding protein eIF4E, the RNA helicase eIF4A, and the scaffolding protei

DNA replication relies on precise coordination between proteins, including the sliding clamp proliferating cell nuclear antigen (PCNA), which encircles DNA to interact with key players in replication and repair. While biochemical studies have demonstrated interactions between PCNA and DNA polymerases δ and ε during DNA synthesis, the functional role of the Pol ε–PCNA interaction in vivo, particula

When children display disruptive behaviour problems at school or at home, their re-lationships with others are affected. Taking a systems perspective into account, where all parts of a system mutually in uence each other, and considering the reciprocal nature of interactions which imply that children are in uenced by and in uence their close surroundings, the present study seeks to examine differeWhen children display disruptive behaviour problems at school or at home, their relationships with others are affected. Taking a systems perspective into account, where all parts of a system mutually influence each other, and considering the reciprocal nature of interactions which imply that children are influenced by and influence their close surroundings, the present study seeks to examine diffe

When the polar vortex meanders and shifts towards the equator, air masses from the tropics and subtropics can be transported towards the pole in so-called tropical-subtropical streamers. These large-scale structures are areas of low potential vorticity and high pressure, containing dry air with high ozone mixing ratios. The presence of these streamers can also be seen in changes in stratospheric o

The role of the architect seems to be constantly renegotiated, due to social change, and technological development. In spite of the proliferation of architectural research, however, architectural knowledge may still be grounded in design experience and cultural values transmitted during the early years of an architect’s training. Furthermore, most scholarly studies on architectural practice and ed

Objective Delivery of a small for gestational age (SGA) infant is a common pregnancy complication among women with SLE. Although disease activity and autoantibodies such as anti-Smith and anti-ribonucleoprotein associate with SGA, underlying pathological mechanisms remain unclear and reliable predictors are lacking. To address this, we applied a proteomic approach to identify proteins associated w

Background: Three-quarters of all mental health problems begins between 10-24 years. When not treated, adolescents and young people with mental health problems are at high risk of abuse, suicide, and substance use, which have long-term consequences that negatively impact physical, and economic productivity. The study aimed to determine the prevalence of mental health problems among secondary schoo

Denna avhandling undersöker hur svenska män som betalar för sex ger mening åt sina handlingar och förhåller sig till ett moraliskt sammanhang präglat av kriminalisering, stigma och offentlig fördömelse. Med utgångspunkt i antropologiska perspektiv på moral, stigma och hemlighållande förstås männens berättelser som uttryck för moraliskt arbete: det pågående, situationsbundna arbete genom vilket indThis dissertation examines how Swedish men who pay for sex make sense of their actions and orient themselves within a moral landscape marked by criminalization, stigma, and public condemnation. Drawing on anthropological approaches to morality, stigma, and secrecy, the study conceptualizes the men’s accounts as forms of “moral work”: the ongoing, situated labor through which individuals seek to su

This bachelor’s thesis examines five selected works of art by the Swedish painter Leander Engström (1886–1927), created between 1915 and 1919. This period is generally regarded as the most significant phase of Engström’s artistic production and was shaped by his time spent in Abisko, as well as by a romantic relationship that coincided with an especially vivid and expressive phase in his work. Eng

This thesis examines Black Archives Sweden (BAS), a contemporary archive centering the experiences of afroswedes and Black people. The archive raises the question of whose story is worthy of telling, and through whose eyes it is being documented. To approach the material, the thesis applies discourse analysis in combination with postcolonial perspectives and theories as well as institutional art t

This paper explores how evolutionary epistemology can offer insights into the discussion of naturalization of epistemology and normativity. Living organisms have an inherent disposition to continue living – i.e., staying in homeostasis – which they accomplish through an anticipatory regulatory process called allostasis. Organisms only survive under certain conditions, and so their actions and pred

Microhabitat choice has been proposed as a mechanism contributing to the maintenance of colour polymorphism in marine gastropods, based on observed associations between shell colour and microhabitat in certain species (e.g. Littorina saxatilis). To examine this hypothesis, different colour morphs of L. saxatilis were studied following a mark-recapture experimental design to assess whether this spe

Context. Stellar radial migration has predominantly been examined in isolated disc galaxies where non-axisymmetric structures drive the process. By contrast, while tidal interactions are known for having an influence, their contribution remains comparatively under explored. The Large Magellanic Cloud (LMC), the nearest disc galaxy to the Milky Way (MW) and currently interacting with the Small Mage

A cell’s ability to sense and respond to the mechanical properties of the extracellular matrix (ECM) is essential for maintaining tissue homeostasis, and its disruption contributes to diseases such as fibrosis, cardiovascular disorders, and cancer. Effective mechanical coupling between the plasma membrane, the underlying filamentous actin (F-actin) cytoskeleton, and integrin-based adhesion complex