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Genotype–phenotype associations can be context-dependent and dynamic in nature leading to heterogeneity of genetic effects across different parts of the phenotype distribution. Quantile regression, an alternative to linear regression for continuous phenotypes, is particularly well suited for detecting and characterizing heterogeneous genotype–phenotype associations. Here, we propose a computationa
Swedish Sign Language [svenskt teckenspråk, STS] has often been described as being the first officially recognised sign language in the world, passed into law in 1981. This was a parliamentary decision that later led to the provision of bimodal-bilingual education and the keeping of a separate school system for deaf students. However, today, STS is not granted the same rights as the five declared
This article examines the 2025 Romanian presidential runoff through the lens of gendered political leadership. It explores the contours of different types of masculinities in politics as performed by the two candidates, George Simion and Nicușor Dan. We analyse the political meanings of gender and sexuality in the candidates’ performances of masculinity and how these both reflect and contest Roman
Acquisition of complement regulators is a virulence strategy used by nontypeable Haemophilus influenzae (NTHi) to evade complement-mediated killing by the host. The major outer membrane protein of NTHi, P5, binds C4b-binding protein and factor H to promote bacterial serum resistance. We show that P5 also binds vitronectin, which inhibits the formation of the membrane attack complex at the terminal
BACKGROUND: The heterogeneity of Alzheimer's disease (AD) and lack of well-validated markers of non-AD factors (e.g. TDP-43) present a substantial challenge for therapeutics. Our prior work showed discordance between tau (T) and neurodegeneration (N) identified non-AD factors in AD through multi-modality imaging. Here we tried a simplified approach using plasma ptau217 and medial temporal lobe (MT
Background: Implementing the evidence-based Individual Placement and Support (IPS) model in welfare states like Sweden faces contextual challenges that often necessitate local adaptations to enhance fit and effectiveness. While fidelity assessments aim to ensure effective outcomes, adaptations may lead to unintended drift from core components. The Model for Adaptation Design and Impact (MADI) helpBackground: Implementing the evidence-based Individual Placement and Support (IPS) model in welfare states like Sweden faces contextual challenges that often necessitate local adaptations to enhance fit and effectiveness. While fidelity assessments aim to ensure effective outcomes, adaptations may lead to unintended drift from core components. The Model for Adaptation Design and Impact (MADI) help
BACKGROUND: Tau pathology distribution in Alzheimer's disease (AD) shows individual spatial heterogeneity, including hemispheric asymmetry. The mechanisms underlying this asymmetry remain unclear. This study explored whether tau asymmetry is linked to reduced inter-hemispheric connectivity, potentially restricting tau spread, or reflects asymmetry in amyloid-beta (Aβ) distribution, indicating hemi
BACKGROUND: Variability of brain amyloid burden across individuals suggests that biological factors may play a role. This study investigates the association between polygenic risk scores (PRS) and amyloid burden in a preclinical Alzheimer's disease (AD) cohort to identify genetic determinants. METHOD: PRS for AD susceptibility (Kunkle et al., 2019) and for CSF-Aβ42 and ptau181 (Jansen et al., 2022
Arsenic contamination in soil and water poses significant health risks globally through contaminated crops. 1,2,3 Modern cultivated rice ( Oryza sativa ), particularly the subspecies japonica , accumulates high levels of arsenic. 1,3,4,5,6 This may possibly result from unintended physiological and genomic changes during rice domestication, which have significantly altered traits such as plant arch
BACKGROUND: Brain function emerges from structural pathways enabling neural connectivity and communication. However, the extent of structural-functional coupling varies across brain regions, and its alteration in aging and early Alzheimer's disease (AD) remains unclear. This study investigated variations in coupling associated with age, sex, and amyloid burden in a cohort of older adults without d
BACKGROUND: Postmortem MRI has opened-up avenues to study brain structure at ultra high-resolution revealing details not possible to observe with in vivo MRI. Here, we present a novel package (purple-mri) which performs tissue segmentation, anatomical parcellation and spatial normalization of postmortem MRI. Additionally, we provide a framework to perform point-wise surface-based group-level studi
BACKGROUND: A considerable portion of patients with amnestic mild cognitive impairment (aMCI) have negative amyloid-β (Aβ) biomarkers and are therefore unlikely to have Alzheimer's disease (AD). Potential causes of cognitive decline in this heterogeneous group include limbic-predominant age-related TDP-43 encephalopathy (LATE), cardio/cerebrovascular diseases, primary age-related tauopathy (PART),
BACKGROUND: Dementia with Lewy Bodies (DLB) is often misdiagnosed or conflated with Alzheimer's Disease (AD) due to overlapping clinical presentations and neuropathological features. The presence of AD-like features correlates with accelerated cognitive decline and a worse overall prognosis. Compared to AD, studies suggest that amyloid uptake in DLB may spare the occipital lobe. This project aims
In this chapter I trace a series of central and well-connected urban squares in Malmö and Lund, Sweden from the 1960s until today. It investigates how the squares have developed in relation to the practice of shopping and other activities during these decades and concludes with the discussion of a few more recent trends. Starting with the deterioration of the open urban markets, followed by the in
While many industrial processes have been thoroughly exposed to machine learning models, the realm of powder metallurgy is still underexplored. This thesis aims to investigate the potential for a machine learning model to predict the characteristics of metal powders after a reduction annealing process using time series process data from the furnace. A supervised learning model was developed to pre
Understanding the behavior of electron spins in nanomaterials is crucial for the advancement of quantum technologies. However, studying single spins presents significant challenges both experimentally and theoretically, as radicals are often unstable under experimental conditions, and sophisticated quantum mechanical approaches with extremely high computational demands, such as CASPT2 and NEVPT2,
A forthcoming taxonomic treatment of the genus Verbascum in Greece in the frame of The Flora of Greece Project necessitates the description of one species and two subspecies as new to science, the upgrading to subspecies rank of two taxa formerly recognized as varieties, as well as the formation of two new combinations. Verbascum bolbes from the regional unit Thessaloniki is here described as a ne
Antimicrobial peptides are widely investigated in the literature, but their mechanism of action and effects on lipid membranes are not completely understood from a physicochemical perspective. In this study, we employed a bioinspired mastoparan from wasp venom, mast-MO, and characterized its interactions with model lipid membranes, either as a supported lipid bilayer or as free-standing vesicles i
