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Lakatos's challenge? : Auxiliary hypotheses and non-monotonous inference
Gerhard Schurz [2001, Journal for General Philosophy of Science, 32, 65-107] has proposed to reconstruct auxiliary hypothesis addition, e.g., postulation of Neptune to immunize Newtonian mechanics, with concepts from non-monotonous inference to avoid the retention of false predictions that are among the consequence-set of the deductive model. However, the non-monotonous reconstruction retains the
Enhanced left-finger deftness following dominant upper- and lower-limb amputation
BACKGROUND: After amputation, the sensorimotor cortex reorganizes, and these alterations might influence motor functions of the remaining extremities.OBJECTIVE: The authors examined how amputation of the dominant or nondominant upper or lower extremity alters deftness in the intact limbs.METHODS: The participants were 32 unilateral upper- or lower-extremity amputees and 6 controls. Upper-extremity
STS-inspired design to meet the challenges of modern ageing. Welfare technology as a tool to promote user driven innovations or another way to keep older users hostage?
The contribution of photosynthetic pigments to the development of biochemical separation methods: 1900-1980
It can't happen, it's a bad idea, it won't last : U.S. economists on the EMU and the euro, 1989-2002
The organizing vision of mobile business intelligence
Osynlighetens mellanförskap: autistiska kvinnors upplevelser och tankar om normalitet och moderskap.
This thesis is about autistic women. It is about how we, as a society, construct and perceive normality and motherhood as a normative ideal for women. It is also about a dis/ability that often goes unnoticed since autism is not defined by any visible markers. Rather, autism is categorized by behaviour considered atypical through the medical gaze. How to make visible the invisible, the in-between
Certified sustainability - on what terms? : a study on Indonesian oil palm smallholders’ and Swedish consumers’ motivations to engage with sustainability certifications
Kirchheimer i Latinamerika- En undersökning av Catch- allpartier i Chile
The Triangle of Mistrust: A Utility's Struggle to Engage Effectively in the Informal Settlements of Nairobi
“Water is life”. During the past decade this phrase has been used repeatedly to emphasize the importance of a number of issues surrounding water services provision including, supply, distribution, governance and political will. This research seeks to investigate the Nairobi City Water and Sewerage Company (NCWSC), a water utility in Kenya, which faces the monumental task of providing water and san
Name your price - a study of a pricing strategy
The InterModel Vigorish (IMV) as a flexible and portable approach for quantifying predictive accuracy with binary outcomes
Bringing Death to Life: The Personifications of Death in Zusak's The Book Thief, Moore's A Dirty Job and Pendle's Death: A Life
This essay examines the personifications of Death in Markus Zusak’s The Book Thief (2005), Christopher Moore’s A Dirty Job (2006) and George Pendle’s Death: A Life (2008). The personifications are analysed in terms of gender, anthropomorphism, (im)mortality, agency in conceptual death and attitude towards their occupation as Death. The personifications are also compared to previous portrayals in r
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Ett smartare Sverige Sacos kongress 2025 Verksamhets rapport januari–juni 2025 1/14 Uppföljning av verksamheten första halvåret 2025 Sammanfattning Under det första halvåret 2025 har Saco bedrivit aktivt påverkansarbete och mediegenomslaget har varit starkt. Därutöver har nya aktiviteter genomförts för att ytterligare stärka samverkan och stöd inom federationen. Rapporter, remissvar, debattartikl
Engineering Af1521 improves ADP-ribose binding and identification of ADP-ribosylated proteins
Protein ADP-ribosylation is a reversible post-translational modification that regulates important cellular functions. The identification of modified proteins has proven challenging and has mainly been achieved via enrichment methodologies. Random mutagenesis was used here to develop an engineered Af1521 ADP-ribose binding macro domain protein with 1000-fold increased affinity towards ADP-ribose. T
Induction of platelet thrombi by bacteria and antibodies.
We have characterized 2 distinct mechanisms through which infectious agents may promote platelet adhesion and thrombus formation in flowing blood, thus contributing to the progression of disease. In one case, the process initiates when the integrin alpha(IIb)beta(3) mediates platelet arrest onto immobilized bacterial constituents that have bound plasma fibrinogen. If blood contains antibodies agai
Toward clinical use of the IgG specific enzymes IdeS and EndoS against antibody-mediated diseases
Alveolar mast cells shift to an FcεRI-expressing phenotype in mild atopic asthma: a novel feature in allergic asthma pathology.
Background: A unique feature of alveolar mast cells is their low high-affinity IgE receptor (FcεRI) expression. Recent discoveries in uncontrolled asthma suggest that the appearance of FcεRI-expressing alveolar mast cells may be a novel disease-specific feature of allergic asthma. This study investigates whether increased FcεRI-expressing alveolar mast cells are present in patients with mild aller
Group B Streptococcus suppression of phagocyte functions by protein-mediated engagement of human Siglec-5
Group B Streptococcus (GBS) is a leading cause of invasive bacterial infections in human newborns. A key GBS virulence factor is its capsular polysaccharide (CPS), displaying terminal sialic acid (Sia) residues which block deposition and activation of complement on the bacterial surface. We recently demonstrated that GBS Sia can bind human CD33-related Sia-recognizing immunoglobulin (Ig) superfami