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BACKGROUND: Owing to the large variation in treatment response among patients with high-risk prostate cancer, it would be of value to use objective tools to monitor the status of bone metastases during clinical trials. Automated Bone Scan Index (aBSI) based on artificial intelligence has been proposed as an imaging biomarker for the quantification of skeletal metastases from bone scintigraphy.OBJE

Objective: The purpose of this study was to explore the influences of gestational age, the choice of fetal fluid compartment, and the algorithm for calculation on the estimation of the base deficit in umbilical cord arterial blood Lit birth. Study design: From 1995 to 2002, cord arterial blood gases and obstetric data were available for 43,551 newborn infants at 37 + weeks of gestation (cohort 1).

Above-ground biomass (AGB) is considered an essential climate variable that underpins our knowledge and information about the role of forests in mitigating climate change. The availability of satellite-based AGB and AGB change (ΔAGB) products has increased in recent years. Here we assessed the past decade net ΔAGB derived from four recent global multi-date AGB maps: ESA-CCI maps, WRI-Flux model, J

Background: Tumour-infiltrating lymphocytes (TILs) are of important prognostic and predictive value in human epidermal growth factor receptor 2-positive (HER2+) breast cancer (BC) and triple-negative breast cancer (TNBC), but their clinical relevance in oestrogen receptor-positive/HER2-negative (ER+/HER2−) remains unknown. The primary study aim was to analyse the prognostic effect of TILs on the B

Background: Lead time (LT) is of key importance in early detection of cancer, but cannot be directly measured. We have previously provided LT estimates for prostate cancer (PCa) using archived blood samples from cohorts followed for many years without screening. Objective: To determine the association between LT and PCa grade at diagnosis to provide an insight into whether grade progresses or is s

The overall aim of this thesis is to gain a clearer picture of the differences in mobility among the young-old living in Sweden’s large metropolitan regions. This thesis comprises four papers. Paper I explores the inclusion of public transport as an element of mobility among the young-old living in the Stockholm region. Paper II presents an analysis of cycling among older people in the city of Mal

This is a proposal to organize a session.Description:The rapid development of the technological progress is constantly reshaping the organization of the firm, raising important labour law issues.One of the red treads of this phenomenon is the shifting of the focus from the “activity” performed by the worker, to the “result” obtained.In the past it was not always possible to measure the output prod

Background: The rapid adoption of robot-assisted laparoscopy in radical prostatectomy has preceded data regarding associated costs. Qualitative evidence regarding cost outcomes is lacking. Objective: This study assessed how costs were affected by robot-assisted laparoscopic prostatectomy (RALP) compared with open surgery. Design, setting, and participants: Cost analysis was based on the dataset of

BACKGROUND AND PURPOSE: Brain imaging is an integral part of the diagnostic work-up for metabolic disorders, and the bedside availability of cranial ultrasonography (cUS) allows very early brain imaging in symptomatic neonates. Our aim was to investigate the role and range of abnormalities seen on cUS in neonates presenting with metabolic disorders. A secondary aim, when possible, was to address t

OBJECTIVES: To evaluate the systemic phenotype associated with the presence of isolated anti-La/SSB antibodies in a large international registry of patients with primary Sjögren's syndrome (pSS) fulfilling the 2002 classification criteria.METHODS: The Big Data Sjögren Project Consortium is an international, multicentre registry created in 2014. Baseline clinical information from leading centres on

Error estimation and data fusion are critical to improving the accuracy of global model- and satellite-based precipitation products for practical applications. However, they face challenges over vast areas of the world due to limited ground observations. Triple collocation (TC) method can overcome this limitation and provide an efficient way for error estimation without the “ground truth” and thus

NASA's Global Ecosystem Dynamics Investigation (GEDI) is collecting spaceborne full waveform lidar data with a primary science goal of producing accurate estimates of forest aboveground biomass density (AGBD). This paper presents the development of the models used to create GEDI's footprint-level (~25 m) AGBD (GEDI04_A) product, including a description of the datasets used and the procedure for fi

Importance: Local steroid injection is commonly used in treating patients with idiopathic carpal tunnel syndrome, but evidence regarding long-term efficacy is lacking. Objective: To assess the long-term treatment effects of local steroid injection for carpal tunnel syndrome. Design, Setting, and Participants: This exploratory 5-year extended follow-up of a double-blind, placebo-controlled randomiz

Background: Survey studies have found that vaccinated persons tend to report more side effects after being given information about side effects rather than benefits. However, the impact of high media attention about vaccine-related side effects on the utilization of health care is unknown. We aimed to assess whether utilization of health care services for newly vaccinated health care workers chang

Purpose: Free prostate specific antigen (PSA) in serum consists of heterogeneous molecular subforms. Recently we developed an immunoassay for selective measurement of a subfraction of free PSA called intact PSA, which has been shown to be closely associated with prostate cancer. We assessed the ability of serum intact PSA to discriminate between benign and malignant prostatic disease. Materials an

Fildelning innebär bland annat nedladdning och tillgängliggörande av upphovsrättsligt skyddade verk på internet. Detta orsakar ekonomiska förluster för rättighetsinnehavarna till verken. För att komma tillrätta med det utbredda fildelningsproblemet har rättighetsinnehavare börjat rikta ersättningsanspråk mot enskilda abonnenter. Detta bland annat genom att utsända förlikningserbjudanden i Sverige File sharing means, among other things, downloading and making copyrighted works available on the internet. This causes economic losses to the rights holders of the works. In order to address the widespread file sharing problem, rights holders have begun to claim compensation from individual subscribers. This, among other things, by sending settlement offers to subscribers in Sweden and Denmark. T

For Tetra Pak to be able to continue its work on minimizing energy usage and waste in its production systems and delivering better solutions for its customers, it is of the utmost importance to understand the products used in the Tetra Pak system. Many of these products are defined as semi-fluid products, which means they can behave like both fluids and solids, depending on the circumstances. Unde

Background: Current consumption levels of animal products (APs) are unsustainable but measures to reduce their consumption are lacking. Simultaneously, APs are widely perceived as healthy which hinders their substitution with other foods. The AP-industry might influence AP consumption as they have the necessary financial means, the interest and the organizational capacity. Objective: To investiga

I Sverige regleras idag tryck- och yttrandefrihetsrätten genom tre av landets fyra grundlagar, främst Tryckfrihetsförordningen (TF) och Yttrandefrihetsgrundlagen (YGL), men övergripande bestämmelser finns även i Regeringsformen (RF). TF och YGL är mycket detaljerat utformade samt teknikbundna, vilket innebär att dess bestämmelser ger ett särskilt skydd åt de yttranden som görs via ett medium. GrunThe Swedish liberty of the press and freedom of speech is regulated by three of the country's four constitutions, mainly the Freedom of the Press Act (TF) and the Fundamental Law on Freedom of Expression (YGL), but overall rules are also regulated in the Instrument of Government (RF). TF and YGL are very detailed formulated and also technology bound (”teknikbundna”), meaning that its provision

Persondosimetri för vårdpersonal, som i sitt yrke exponeras för joniserande strålning, är ständigt ett hett ämne och under konstant utveckling. Stråldosen mäts och registreras för att uppfylla riktlinjer och lagar, som syftar till att hålla personal säkra vid arbete med joniserande strålning. Det finns en rad olika sätt att mäta stråldoser till en människa. För att effektivt uppskatta och mäta strWithin the field of medical radiation protection, radiation safety and personal dosimetry, there is a constant pursuit for improving existing methods and evaluating new approaches for measuring and quantifying the radiation doses that hospital staff may be exposed to in their clinical work. There are numerous ways of determining what doses the staff are being exposed to and the most commonly used