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Post-translational modifications (PTMs) of histones including acetylation, methylation, and ubiquitination are known to be involved in the epigenetic regulation of gene expression and thus can have an important role in tumorigenesis. A number of PTMs have been linked to pancreatic cancer and are frequently studied as potential targets for cancer therapy or diagnosis. The availability of biobank-st

Observational studies suggest that higher birth weight (BW) is associated with increased risk of breast cancer in adult life. We conducted a two-sample Mendelian randomisation (MR) study to assess whether this association is causal. Sixty independent single nucleotide polymorphisms (SNPs) known to be associated at P < 5 × 10 −8 with BW were used to construct (1) a 41-SNP instrumental variable (IV

Serum levels of Anti-Mullerian Hormone (AMH) have been shown to be biomarker for prediction of the quantitative aspects of ovarian reserve. On the male side, sperm chromatin structure assay (SCSA) DNA fragmentation index (DFI) has been demonstrated to be an important predictor of outcomes in standard IVF procedures but to less degree in intracytoplasmic sperm injection procedures (ICSI). The purpo

Godssektorn spås bli en tidig användare av självkörande fordonsteknik. Minskade drivmedelskostnader, ökad flexibilitet i ruttplaneringen och utökade drifttider är exempel på incitament för godsföretag att ställa om till en självkörande lastbilsflotta. Automatiseringen kommer mest sannolikt ske gradvis. I tidiga skeden spås självkörande lastbilar (AT:s) ha en konservativ körstil där körfältsbyten u

Innovation is the means for successful implementation of new ideas in the company to produce materials, processes, outputs, or services which are new to the company. The vision of any innovation driven company is accomplished with a good inflow of innovative talents blessed with the capabilities of thinking out of box and generating new ideas with the entrepreneurial mindset. Thereby, managing inn

Reducing the environmental impact from packaging has become a highlight in both consumers and industrial interest. The paperboard from virgin fibres is commonly used in the folding carton packaging across various type of products, including health care products. It provides the premium perception to the product value yet less circulates the fibre economy. After the paperboard folding carton serves

The report is based on the use of alternative materials in road construction. The alternative materials included are crushed concrete, crushed asphalt and air cooled blast furnace slag. Differences and similarities exist between the use of alternative materials in Sweden and Denmark. Denmark has no use of air cooled blast furnace slag, but they have a greater use of crushed concrete and crushed as

Matvaruhandeln på nätet växer och en stor del av matvaruinköpen online levereras med hemleverans. Den hemleveransmodell som idag används i störst utsträckning låter kunderna välja ett tidsfönster för när de vill ha sin leverans. Det innebär att rutterna måste anpassas efter olika tidsfönster, vilket resulterar i ineffektivitet och låg fyllnadsgrad i lastbilarna. Detta, i sin tur, gör att leveranseThe online market for groceries is continuously growing. Many of the online grocery purchases are home delivered, and the model that is currently the most commonly used allows the customer to pick a delivery time slot. This means that the delivery routes must be adapted according to time windows, which results in inefficient routes, a lot of half-empty vehicles, and hence in costly deliveries for

This report provides an analysis and evaluation of the current spatial, environmental and financial resilience of Rågsved Centre in Stockholm. Furthermore, local future risks on resilience are also discussed and the total analysis is synthesised in a new resilient spatial interpretation of the centre. Methods of analysis include a narrative format that comprise of twelve semi-structured interviews

Idrottsrörelsen är i dag Sveriges största folkrörelse och idrotten är världen över en angelägenhet för väldigt många människor. Idrottsrörelsen har en lång tradition av autonomi och självbestämmande, som tillsammans med en tilltagande kommersialisering har förstärkts av ett stort användande av skiljeavtal och egna skiljenämnder. Detta har gett upphov till frågan när allmänna domstolar egentligen bToday, the sports movement is the largest social movement in Sweden, and sports are a matter for many people all around the world. The Swedish sports movement has enjoyed a sense of autonomy and independence during a long period of time, and this order has been enhanced due to an increased extent of commercialisation, together with a vast use of arbitration agreements and own arbitration panels. T

Uppsatsen behandlar kommunal delegation och speciellt den myndighetsutövning mot enskild som sker på socialrättens område. Framförallt gäller myndighetsutövningen tvångsomhändertaganden och ansökan om tvångsvård enligt LVU. Uppsatsen består av en deskriptiv del där gällande rätt avseende kommunal delegation utreds. Begrepp som behandlas är bland annat ren verkställighet, beslut, lekmannastyrning, This thesis deals with municipal delegation and in particular the excercise of authority over individuals within the field of social law. Said exercise of authority primarily concerns compulsive preventive detention and applications for compulsory care under LVU. The thesis consists of a descriptive part where the applicable law regarding municipal delegation is investigated. Concepts covered incl

Abstract Authors: Johanna Ottenborg och Viktor Sjöström Title: The spider in the web – school counselors role in the meeting with self-harming adolescents Supervisor: Malin Arvidson According to the new regulations in the Swedish Education Act, all students should have access to a school counselor. Schools are a workplace where mainly teachers work and where education is the prevailing approach

Abstract Author: Sebastian Hallin Title: To speak, talk or chat: a study of social workers reflections on approaches to communication, parlance and expression. [translated title] Supervisor: Helena Hansson The purpose of this study was to investigate social workers that work with clients in substance abuse and addiction problems. The study aimed to visualize approaches to parlance, communication

The interest for renewable energy within Australia is growing and the New South Wales (NSW) Government has committed to a Renewable Energy Target scheme of 20 percent renewable energy by 2020. Wind energy is a mature renewable energy resource, which has been successfully deployed for electricity generation around the world. It is further believed to be a viable option to help expand the renewable

This MSc Thesis’s main objective is to determine the impact of transformer inrush currents in the grid and develop a tool that helps E.ON Energidistribution AB evaluate transformer sizing. The motivation of E.ON is to have a more precise way to estimate the energization consequences of increasing the transformer size in the grid, since currently is being used a rule of thumb that relates the trans

The aim of this thesis project was to develop or lay the base for an innovative oat and chickpea based fermented product. From a previous thesis project, Glucanova AB had developed an oat and chickpea base called OatChic®. The goal of this thesis project was to evaluate the effects of fermentation on OatChic® by characterizing prototypes based on the beta-glucan content, phytic acid content, sugar

Children are not only negatively affected by being exposed to violence themselves, but they are also affected by witnessing violence. For example, mental health issues and not getting the support that they need. In 2021, the law “barnfridsbrott” came into effect, making it illegal to allow a child to witness violence between people they have a close relationship with. This study is about the conce

Study purpose: The maritime shipping industry, particularly the commercial sector, is a significant contributor to carbon emissions and environmental pollution. Various solutions are being proposed to enhance the sector's sustainability, including the adoption of wind propulsion technologies. However, the economic feasibility of these technologies on a large scale remains uncertain. Despite th

Examensarbetet undersöker de utmaningar som finns vid tillämpning av marknadsmanipulationsbestämmelserna. Marknadsmanipulation är ett brott som kräver uppsåt, men det saknas specifika krav på vilken typ av uppsåt som krävs. Detta gör uppsåtsbedömningen svår, speciellt vid mindre allvarliga överträdelser. Enligt "direktivet" MAD II ska marknadsmanipulation vara straffbart, men det finns vThis thesis examines the challenges in applying the provisions of market manipulation. Market manipulation is a crime that requires intent, but there are no specific requirements for the type of intent required. This makes the assessment of intent difficult, especially in cases of less serious violations. According to the "Market Abuse Directive" (MAD II), market manipulation should be p

Den sociala marknadsekonomi som eftersträvas inom EU har sin grund i begrepp som konkurrenskraft, välfärd och innovation. Just innovation anses utgöra en viktig och dynamisk del av marknaden genom att främja fri konkurrens. Patentpooler har av många ansetts vara ett gott medel för att gynna innovation och dessa utgör därmed en viktig spelare på den fria marknaden. Patentpoolen innebär i grunden etThe market economy sought within the European Union is based on concepts such as competitiveness, welfare, and innovation. Innovation is, in particular, considered to be an important and dynamic part of the market by promoting competition. The patent pool is based on an arrangement between competitors. Anyone who has become acquainted with competition law is well aware of its critical attitude tow