Filtyp
Emerging knowledge of the role of atheroprotective immune responses in modulating inflammation and tissue repair in atherosclerotic lesions has provided promising opportunities to develop novel therapies directly targeting the disease process in the artery wall. Regulatory T (Treg) cells have a protective role through release of anti-inflammatory cytokines and suppression of auto-reactive effector
We perform a comparative study of exact and approximate time-evolved densities in small Hubbard chains. The approximate densities are obtained via many-body perturbation theory (Hartree-Fock, 2(nd) Born, GWand T-matrix approximations) within the framework of the time-dependent Kadanoff-Baym equations. Benchmarking approximate results against exact ones allows us to address two rather fundamental i
Wheat flour and cane sugar were partially substituted (50 and 75%) by a mango-processing by-product (MPB) as an added-value food ingredient in muffins. Their sensory analysis, chemical composition, antioxidant activity and in vitro starch hydrolysis properties were studied. Sensory analysis showed statistically significant difference (p < 0.05) between control and muffins 75% MPB substituted level
Sweden has been a pioneer in the treatment of haemophilia, with the first concentrate available in the 1950s. Treatment has improved over the years to its current state-of-the art. The aim of the current study was to evaluate the long-term outcome of haemophilia in terms of incidence, morbidity and mortality. Patients diagnosed with haemophilia A or B registered at the national haemophilia centres
No consensus treatment regime exists beyond surgery for malignant peripheral nerve sheath tumours (MPNST), and the purpose of the present study was to find new approaches to stratify patients with good and poor prognosis and to better guide therapeutic intervention for this aggressive soft tissue cancer. From a total of 67 MPNSTs from Scandinavian patients with and without neurofibromatosis type 1
OBJECTIVE: This study aims to analyze the diagnostic workup in patients referred for endovascular mesenteric revascularization for symptomatic mesenteric atherosclerotic disease. MATERIAL AND METHODS: Fifty-five patients were identified between 2006 and 2011. Median follow-up time was 24 months. RESULTS: Median age was 71 years, 67 % were women. Forty patients had acute on chronic mesenteric ische
Background Prognostic information for asymptomatic patients with aortic stenosis (AS) from prospective studies is scarce and there is no risk score available to assess mortality. Objectives To develop an easily calculable score, from which clinicians could stratify patients into high and lower risk of mortality, using data from the Simvastatin and Ezetimibe in Aortic Stenosis (SEAS) study. Method
Objective The objective of this article is to determine if maternal obesity is associated with an increased risk of Down syndrome in the offspring and whether the risk estimates for trisomy 21 based on combined screening is affected by maternal body mass index (BMI). Methods Study group I consisted of a nationwide cohort of 1 568 604 women giving birth; outcome was infants born with Down syndrome
Background: Apolipoprotein J (ApoJ) is a component of plasma high-density lipoproteins. Previous studies have shown progressive recovery of ApoJ sialic acid content with increased duration of alcohol abstinence. Therefore, the sialic acid index of plasma apolipoprotein J (SIJ) seems to be a promising alcohol biomarker. Phosphatidylethanol (PEth) is a direct ethanol metabolite and has recently attr
We present comprehensive results on continuous atmospheric cluster and particle measurements in the size range similar to 1-42 nm within the European Integrated project on Aerosol Cloud Climate and Air Quality interactions (EUCAARI) project. We focused on characterizing the spatial and temporal variation of new particle formation events and relevant particle formation parameters across Europe. Dif
Objective: We studied the independent and joint effects of the genes encoding alpha-synuclein (SNCA) and microtubule-associated protein tau (MAPT) in Parkinson disease (PD) as part of a large meta-analysis of individual data from case-control studies participating in the Genetic Epidemiology of Parkinson's Disease (GEO-PD) consortium. Methods: Participants of Caucasian ancestry were genotyped for
Filamentous fungi produce asexual dispersive spores (conidia), when conditions are not suitable for apical extension growth. Conidiation (the process by which conidia produced) in genus Penicillium has attracted considerable interest because of its wide usage in different areas. In addition, several Penicillium species are pathogenic toward humans and plants, causing crop spoilage as well as decay
Popular Abstract in Swedish Ett antal optiskt aktiva metalloorganiska Phe-AAn-Phe subenheter har syntetiserats via intramolekulär cyklisering av motsvarande bis(aminosyra)derivat. Bis(aminosyra)derivaten var i sin tur erhållna från en förbättrad multistegssyntes, vars nyckelsteg är Horner-Wadswort-Emmons olefinering av metalloorganiska aldehyder med fosfonylglycin-reagens, enantioselektiv hydrogenSeveral optically active organometallic Phe-AAn-Phe peptidomimetics and macrocyclic Phe-(Phe)n peptides have been synthesized by either intra- or intermolecular peptide bond formation of the corresponding bis(amino acid) derivatives. The key bis(amino acid) derivatives were available from an improved multi-step synthetic route, utilising Horner-Wadswort-Emmons olefination of organometallic aldehyd
Popular Abstract in Swedish Vi lever i ett samhälle under ständig utveckling där användandet av nya kemikalier ökar explosionsartat. Med vardagligt användande av avancerade material såsom extremt tunna skärmar, billiga och miljövänliga bekämpningsmedel och läkemedel – vilka ofta är inspirerade av naturens komplexitet – kommer ett behov av organisk syntes. För att tillverka den här typen av komplicThis thesis deals with the development of novel methodologies for the synthesis of hetero- and carbocycles enabled by transition metal catalysis. The second chapter of the thesis describes a gold-catalyzed three-component reaction to form a variety of substituted oxazoles from readily available N-benzylimines, terminal alkynes, and acyl chlorides. Sacrificial benzyl groups are used to merge two o
Popular Abstract in English Fungi are multi-cellular eukaryotic organisms which form thread-like filaments called hyphae. They form reproductive structures called sporocarp (also known as mushrooms). Most fungi are saproptrophs, feeding on dead or decaying material while many are also parasitic, feeding on living organisms. In addition, most vascular plants are always in symbiotic association withEctomycorrhizae is the dominant type of mycorrhiza found in association with tree roots in boreal and northern temperate forests. In this symbiosis, the fungal partner derives energy from photosynthates provided by the host trees and in return delivers soil-derived nutrients such as nitrogen (N). The majority of N in forest soils is embedded in recalcitrant organic matter–protein complexes. Ectomy
This thesis contains two different aspects of my research work towards physics in proton-proton collisions in the ATLAS experiment at the LHC. The first part is focused on the understanding and developing of a calibration system to obtain the best possible charged particle reconstruction in the Transition Radiation Tracker. The method explained in this thesis is the current calibration technique u
The first part of this paper aims at identifying the timing of famines in the Nordic countries since the middle ages. This is done by using qualitative famine reports from the literature since quantitative data on famines are scarce or non-existent, at least before the early modern period. We supplement the reports with climate data and price data. Our survey indicates that widespread famine was a
Both Haemophilus influenzae type b (Hib) and nontypeable H. influenzae (NTHi) are important human pathogens causing invasive and mucosal infections. Currently there are number of vaccines available against Hib infections. Hib vaccines consist of the capsular polysaccharide antigen, polyribosyl ribitol phosphate (PRP) of Hib, coupled to different protein carriers. These vaccines are not effective a
The aim of this paper is to study the extent to which non-Annex I countries are implementing or exploring select actions that support both climate change mitigation and sustainable development objectives in the energy sector. The research is based on a survey of the national communications of 100 non-Annex I Parties to the UNFCCC. Although national communications are intended to provide informatio
Agri-environment schemes (AES) have been introduced to mitigate negative environmental effects caused by increased agricultural intensification in Europe. However, there is still debate on whether currently available incentives are efficiently enhancing farmland biodiversity. Moreover, agri-environment schemes often lead to a yield reduction, which has been argued to potentially increase pressure
