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Background: The number of new cases of type 1 diabetes mellitus (T1DM) has increased substantially in recent years and it is now one of the most common long-term endocrine disorders in childhood. In Sweden the child and family are hospitalised in accordance with the national guidelines for one to two weeks at diagnosis. The purpose of this study was to describe parents' perceptions of the educatio

Popular Abstract in Swedish I forskningsparker (Science Parks) finns ett antal resurser tillgängliga för de teknologibaserade företag (NTBF) som valt att lokalisera sig i dessa parker. Om företagen använder dessa resurser kan de också lättare bygga upp den resursbas som företag behöver för att kunna utvecklas och växa. I avhandlingen har tre kategorier av forskningsparksresurser identifierats: UniIn this thesis a strategy perspective (the resource-based view) is applied to the New Technology-Based Firms (NTBFs) in Science Parks, arguing that the Science Park provides the firms with a set of resources that if used could help them build their resource base and thus develop and grow. Three categories of resources are identified in the Science Park; University related resources, Science Park f

The ruptured anterior cruciate ligament (ACL) leads to immediate symptoms that severely affect the individual and receives great attention among the scientific community, yet there is still no consensus on the optional form of treatment. An ACL injury is also a well known high risk factor for the development of knee osteoarthritis (OA) some decades later. Knee OA development after an ACL injury is

SufA, which belongs to the subtilisin-like serine protease family, contains a non-canonical Asp-His-Ser catalytic triad. Under in vitro conditions, SufA is capable of human fibrinogen hydrolysis leading to inhibition of fibrin network formation, thus suggesting its important role in the development and progression of Finegoldia magna infections. In addition, it has been demonstrated that SufA can

Objectives To determine whether serum vascular endothelial growth factor (s-VEGF) levels and VEGF gene expression in tumor tissue predict survival of diffuse large B-cell lymphoma (DLBCL) patients treated with chemoimmunotherapy. Methods VEGF levels were measured in serum samples from 102 patients <65yrs with high-risk DLBCL using a quantitative sandwich enzyme immunoassay technique. Exon array da

P>Infection of mice with the gastrointestinal nematode Trichuris muris represents a valuable tool to investigate and dissect intestinal immune responses. Resistant mouse strains respond to T. muris infection by mounting a T helper type 2 response. Previous results have shown that CD4+ T cells play a critical role in protective immunity, and that CD4+ T cells localize to the infected large intestin

Sweden’s rapid economic growth after World War II meant that the native labour supply was incapable of meeting the high demand, especially for industrial labourers. Three agreements on organised collective transfers were signed, but a large majority of the labour migrants came on their own initiative. Not all applicants were equally welcomed. In this article, logistic regressions are used to inves

Femoral neck fractures in children and young adults are rare, but have a high risk of avascular necrosis (AVN) and subsequent gradual collapse of the femoral head. In 2006, we initiated the use of scintigraphy for the diagnosis of vascular impairment after a cervical fracture in children. In the present retrospective case study, we evaluated the effect of the remaining postoperative circulation in

Objectives: Genome-wide association (GWA) studies still rely on the common-disease common-variant hypothesis since the assumption is associated with increased power. In GWA studies, polymorphisms are genotyped and their association with disease is investigated. Most of the identified associations are indirect and reflect a shared inheritance of the genotyped markers and genetically linked causal v

Pre-fractionation of a complex mixture of proteins increases the resolution in analytical separations of proteins from cells, tissues or organisms. Here we demonstrate a novel method for pre-fractionation of membrane proteins by a detergent-based aqueous two-phase system. Membrane proteins are strongly under-represented in proteomic studies based on two-dimensional electrophoresis (2-DE). As a mod

Theoretical work on intraguild predation suggests that if a top predator and an intermediate predator share prey, the system will be stable only if the intermediate predator is better at exploiting the prey, and the top predator gains significantly from consuming the intermediate predator. In mammalian carnivore systems, however, there are examples of top predator species that attack intermediate

The aim of this study was to assess the agreement between observers analyzing activity patterns during truck engine assembly work based on video recordings. Two observers observed the recordings of nine workers, on the average 2.2 h long, assigning activities to four activity categories. For each activity category data were obtained on the mean duration of uninterrupted sequences of activities and

Background Cultural competency can be understood as those learned skills which help us understand cultural differences and ease communication between people who have different ways of understanding health, sickness and the body. Recently, medical schools have begun to recognise a need for cultural competency training. However, few reports have been published that articulate and evaluate cultural c

AIMS: To present descriptive data, study psychometric abilities, and investigate the characteristics of non-respondents to SF-12. METHOD: The study had a randomized sample (n=4278; age: 75-105) stratified in four age groups. Factor analyses were performed to investigate the factor structure of the instrument, and convergent and discriminant validity was assessed by correlation between summary scor

Evaluation of prophylactic treatment of haemophilia requires sensitive methods. To design and test a new magnetic resonance imaging (MRI) scale for haemophilic arthropathy, two scales of a combined MRI scoring scheme were merged into a single scale which includes soft tissue and osteochondral subscores. Sixty-one joint MRI's of 46 patients with haemophilia were evaluated by four radiologists using

Pollinators face multiple pressures and there is evidence of populations in decline. As demand for insect-pollinated crops increases, crop production is threatened by shortfalls in pollination services. Understanding the extent of current yield deficits due to pollination and identifying opportunities to protect or improve crop yield and quality through pollination management is therefore of inter

Background. The symptoms of obsessive-compulsive disorder (OCD) are highly heterogeneous and it is unclear what is the optimal way to conceptualize this heterogeneity. This study aimed to establish a comprehensive symptom structure model of OCD across the lifespan using factor and network analytic techniques.Methods. A large multinational cohort of well-characterized children, adolescents, and adu

Background: The 2017 Alzheimer’s disease (AD) Strategic Biomarker Roadmap (SBR) structured the validation of AD diagnostic biomarkers into 5 phases, systematically assessing analytical validity (Phases 1–2), clinical validity (Phases 3–4), and clinical utility (Phase 5) through primary and secondary Aims. This framework allows to map knowledge gaps and research priorities, accelerating the route t

Popular science summary Complex I, let me see your true color Every day of our lives our body performs many different tasks to let us survive, such as brain activity, muscle contractions or smaller tasks like cell- repair or -division. All those tasks require energy. The energy currency of our body is called ATP (adenosintriphosphate), a molecule that lets us perform many reactions in our body.

The ambition of this thesis was to provide Scania with a program that can calculate power losses in hypoid gears from gear teeth mesh using the programming language Python. The program should be able to calculate power losses on different points on the gear flank to help designers and engineers in the development face of a new axle gear. Because of governmental requirement and costumers’ wish to m