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BACKGROUND: Chronic obstructive pulmonary disease (COPD) has many known dysregulated inflammatory proteins. A disintegrin and metalloproteinase 17 (ADAM17) is a protease that sheds several proteins involved in COPD pathogenesis. The aim was to investigate ADAM17, its phosphorylated form (pADAM17) and its substrates in bronchoalveolar lavage (BAL) and blood from COPD and control subjects. METHODS:

Background and purpose: Neuroblastoma is the most common extracranial solid tumour in children. Radiotherapy is commonly part of the multimodal treatment for high-risk patients. The aim of this study is to analyse doses to organs at risk (OAR) in comparative proton and photon treatment plans for children treated for neuroblastoma and report side effects. Patient/material and methods: All children

Aims To explore the prevalence and incidence of paediatric implantable cardioverter-defibrillator (ICD) patients in Sweden and identify risk factors associated with appropriate shocks and adverse events. Methods and results We performed a nationwide, retrospective cohort study of ICD use in paediatric patients (<19 years) between 1995 and 2017; 120 patients underwent ICD implantation at median age

Background: Bile leakage is a severe complication after cholecystectomy and is associated with an increased risk of morbidity and mortality. The aim of this study was to evaluate the incidence of bile leakage post-cholecystectomy and to identify potential risk factors and their association with changes in the incidence of bile leakage over time. Methods: Demographic and perioperative data of all p

Intraocular lens (IOL) exchange after cataract surgery is unusual but may be associated with suboptimal visual outcome. The incidence of IOL exchange has not been consistently estimated. Such information is invaluable when counseling patients prior to cataract surgery. We examined the incidence of, and indications and risk factors for, IOL exchange after cataract surgery. We also assessed visual o

1. Rat chylomicrons were labelled with 125I with 69--72% of the iodine in the protein moiety. Less than 1 nmol of iodine was incorporated per nmol of protein. Of the peptide radioactivity 44--56% was in apolipoprotein A-1, 30--40% in the C peptides and 11--15% in apolipoprotine B. The arginine-rich peptide, which accounted for about 14% of the chylomicron protein mass as determined by scanning of

Studying the full universe of nearly 390,000 French patents filed between 1791 and 1900, I show that the nineteenth-century gender patenting gap arose less at the patent office than through unequal access to practical knowledge, collaborators, and time across the life course. I identify 4,165 women inventors using gender-specific honorifics, classify patents with machine learning, reconstruct the

The aim of this paper is to study the extent to which non-Annex I countries are implementing or exploring select actions that support both climate change mitigation and sustainable development objectives in the energy sector. The research is based on a survey of the national communications of 100 non-Annex I Parties to the UNFCCC. Although national communications are intended to provide informatio

Letter of credit law are governed by two overriding principles. The principle of autonomy of the credit and the doctrine of strict compliance. The principle of autonomy can be read out of articles 4, 5 and 14 (a) UCP 600 and stipulates that banks deal with documents and not with goods. A letter of credit is a separate transaction from the sales contract and the bank isn't bound to the contract

Virus är icke levande organismer som infekterar levande celler och förökar sig med hjälp av cellernas maskineri. De kan infektera alla typer av liv och de är totalt beroende av en värdcell. Alla virus innehåller genetiskt material samt en så kallad viruskapsid. Denna kapsid kan ha olika struktur och består av identiska proteinenheter. Kapsidens uppgift är att skydda det genetiska materialet. DettaAll viruses are composed of both genetic material and a capsid. The capsid is composed by identical protein subunits and the purpose is protection of the genetic material, in this case RNA. This project is about cowpea chlorotic mottle virus, also called CCMV, which is a plant virus and the disassembly and reassembly mechanisms of the capsid are investigated to understand how the capsid proteins a

Microalgae belong to the group of the oldest microorganisms that can grow in both fresh and marine water. Microalgal biomass is a rich source of vitamins, lipids, pigments and essential amino acids. Microalgal biomass can be used without cracking and fractionation or it can be cracked, fractionated and purified to get particular components like vitamins, pigments, omega-3 oils and proteins. But du

Thesis purpose: to develop theory that can explain the contradictions that we see in contemporary society in the choice of cooking salt. Salt consumption can cause severe health problems. Consumers in the middle and upper classes are health aware, but seem to have other motivations for their choice in cooking salt. As appears in the hype that we see around cooking salt and the increased specialisa

Popular science summary: Transcriptional regulation of HIF-2α in neuroblastoma Neuroblastoma is the most common solid tumor in childhood. The presence of hypoxia -regions of low levels of oxygen- causes a more immature tumor phenotype that is related to a more aggressive form of this cancer. Hypoxia is mainly directed by Hypoxia Inducible Factors (HIF)-1α and HIF-2α. High levels of HIF-2α expre

Modulbaserad lakvattenbehandling - en möjlighet att minska soptipparnas påverkan på människa och miljö? Uppemot 8000 gamla övergivna deponier och ett 70-tal aktiva deponier finns i Sverige. Gemensamt för dessa är att de kan ge upphov till ett förorenat lakvatten. Genom tillämpningen av ett modulbaserat reningssystem kan effekterna på människa och miljö begränsas. Modulsystemet har visat sig vara fA change in legislation has resulted in that many of Sweden’s municipal landfills were closed in the beginning of this century. After landfill completion, the oper-ator is responsible for at least 30 years to take action with regard to the protec-tion of human health and the Environment. In contribution Swedish landfill owners are facing increasing demands on local leachate treatment due to a chan

Dangdut as the most popular music in Indonesia is highly sexualized on its representation of women despite the fact that Indonesia is a religious country. Dangdut’s sexualization is prominent on its performance, lyrics and culture. Banality, is the face of dangdut. During its public shows, many of the male audiences are more often than not intoxicated and engage in physical fights. Yet to date, th

The flesh-eating bacterium and inflammation run amok Streptococcus pyogenes is a bacterium that can infect humans and cause a wide range of symptoms, from the common strep throat to life-threatening infections. In rare cases, when this bacterium pushes its way down into our deeper skin layers, like in necrotizing skin and soft-tissue infection (NSTI), the destruction of the local tissue sometimes

Stretch of vascular smooth muscle stimulates growth and proliferation as well as contraction and expression of contractile/cytoskeletal proteins, all of which are also regulated by calcium-dependent signals. We studied the role of the calcium- and integrin-activated proline-rich tyrosine kinase 2 (PYK2) in stretch-induced responses of the rat portal vein loaded by a hanging weight ex vivo. PYK2 ph

Objective This study assessed pesticide exposure of children in rural Nicaragua in relation to parental pesticide use, from around conception to current school age, as part of an epidemiological evaluation of neurodevelopment effects. Methods We included 132 children whose parents were subsistence farmers or plantation workers, or had an agricultural history. As proxies for children's long-term ex

OBJECTIVE: To study the association of physician's sex with blood pressure, lipid control, and cardiovascular risk factors in treated hypertensive men and women, stratified for the sex of their physician. METHODS: In a cross-sectional survey of hypertensive patients, 264 primary care physicians (PCPs), 187 men and 77 women from across Sweden, recruited 6537 treated hypertensive patients (48% men)

Background: Nocturia, a common complaint in aging men and women, is frequently cited as the cause of nocturnal awakenings leading to sleep loss, daytime fatigue, and reduced quality of life (QOL). Objective: Investigate the association of nocturia with QOL and depressive symptoms among men and women. Design, setting, and participants: A population-based epidemiologic survey of urologic symptoms am