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4-aminobiphenyl-hemoglobin adducts and risk of smoking-related disease in never smokers and former smokers in the European prospective investigation into cancer and nutrition prospective study

The aim of this study was to evaluate whether biomarkers of environmental tobacco smoke exposure [i.e, 4-aminobiphenyl-hemoglobin (4-ABP-Hb) adducts] were predictive of the risk of tobacco-related cancers and diseases. We did a case control study nested within the European Prospective Investigation into Cancer and Nutrition, involving 190 controls and 149 cases (incident cancer of the lung, bladde

Fire behaviour of beds and upholstered furniture - an experimental study (Second test series) Part 1

A series of twelve full scale experiments with upholstered furniture and beds has been carried out. Ten experiments were performed inside an extensively equipped compartment with a door opening. In order to study the influence of the room on the fire development two experiments were carried out in the open outside the compartment. One experiment in the room was made with restricted ventilation sim

Incidence of diabetes in middle-aged men is related to sleep disturbances.

OBJECTIVE—Sleep deprivation in healthy men has been experimentally found to result in disturbances in glucose metabolism and in sympathovagal imbalance. The aim of the present study was to investigate whether sleep disturbances and elevated resting heart rate are associated with increased risk of developing diabetes. RESEARCH DESIGN AND METHODS—A group of 6,599 initially healthy, nondiabetic men

Cardiovascular responses to intravenous calcitonin gene-related peptide (CGRP) in the albino rabbit

The regional sensitivity of different vascular beds to i.v. CGRP was investigated in the albino rabbit by using the microsphere method. Experiments were performed without pre-treatment on both conscious and pentobarbital-anaesthetized animals. In addition, in one series on conscious animals, rabbits were pre-treated with indomethacin in order to reduce the formation of prostaglandins. In another s

Respective effects of end-expiratory and end-inspiratory pressures on alveolar recruitment in acute lung injury

Objective. A low tidal volume can induce alveolar derecruitment in patients with acute lung injury. This study was undertaken to evaluate whether this resulted mainly from the decrease in tidal volume per se or from the reduction in end-inspiratory plateau pressure and whether there is any benefit in raising the level of positive end-expiratory pressure (PEEP) while plateau pressure is kept consta

Cell-specific processing of chromogranin A in endocrine cells of the rat stomach

The rat stomach is rich in endocrine cells. The acid-producing (oxyntic) mucosa contains ECL cells, A-like cells, and somatostatin (D) cells, and the antrum harbours gastrin (G) cells, enterochromaffin (EC) cells and D cells. Although chromogranin A (CgA) occurs in all these cells, its processing appears to differ from one cell type to another. Eleven antisera generated to different regions of rat

Understanding what it means to be a Montessori teacher: Teachers' reflections on their lives and work.

Popular Abstract in Swedish Det övergripande syftet med föreliggande studie är att utveckla en bättre förståelse om vad det innebär att vara montessorilärare. Utgångspunkten är lärarnas egna liv- och verksamhetsberättelser. Insamling av data har skett genom loggböcker, intervjuer, skriftliga reflektioner och diskussioner. Analys av lärarnas livsberättelser i samband med övriga data har granskats fThe overall aim of this study has been to come to a better understanding of what it means to be a Montessori teacher, by getting a group of Montessori teachers to reflect on their lives and work. Data exploration has comprised journals, interviews, written reflections and collaborative contextual analysis. Analysis of the teachers' occupational life histories and the findings as a whole have been

Experimental Investigations of Lean Stability Limits of a Prototype Syngas Burner for Low Calorific Value Gases

The lean stability limit of a prototype syngas burner is investigated. The burner is a three sector system, consisting of a separate igniter, stabilizer and Main burner. The ignition sector, Rich-Pilot-Lean (RPL), can be operated with both rich or lean equivalence values, and serves to ignite the Pilot sector which stabilizes the Main combustion sector. The RPL and Main sectors are fully premixed,

Small States and the Art of Influence in the EU

Are there special ways of exerting influence for small states in a complex multi-actor governance system such as the EU? Intergovernmental theories of European integration emphasize great power nota bene the Franco-German axis, but other observers suggest that smaller member states may actually use the EU institutions to their advantage. Based on literature about small states in international rela

Arcanobacterium haemolyticum, clinical, diagnostic and therapeutic aspects

Popular Abstract in Swedish Arcanobacterium haemolyticum (A. haemolyticum) beskrevs för första gången under namnet Corynebacterim haemolyticum av MacLean och medarbetare 1946. Bakterien odlades fram från svalget hos patienter med halsont och från sår. Patienterna bestod av amerikanska soldater och infödda öbor i Stilla havet. Från olika delar av världen har senare beskrivits halsont och utslag hosIn an 18-month period all throat cultures in our laboratory were examined for Arcanobacterium haemolyticum and clinical information was obtained. The great majority of the patients suffered from pharyngitis or tonsillitis, accompanied by a rash in 46% of cases. One third of the patients had a history of recurrent tonsillitis. Three types of exanthema was described, scarlatiniform, urticarial and e

Cardiovascular risk factors and metabolic syndrome in people with established psychotic illnesses : baseline data from the IMPaCT randomized controlled trial

BACKGROUND: The aims of the study were to determine the prevalence of cardiometabolic risk factors and establish the proportion of people with psychosis meeting criteria for the metabolic syndrome (MetS). The study also aimed to identify the key lifestyle behaviours associated with increased risk of the MetS and to investigate whether the MetS is associated with illness severity and degree of func

Inhibitor development in previously untreated patients with severe haemophilia A : a nationwide multicentre study in Finland

Introduction: Currently the most serious treatment complication of haemophilia is the inhibitor development (ID), i.e. neutralizing antibody development. Aim: This nationwide multicentre study in Finland evaluated the incidence and risk factors of ID in previously untreated patients (PUPs) with severe haemophilia A (FVIII:C < 0.01 IU mL−1). Methods: We enrolled all PUPs (N = 62) born between June

Mentally disordered offenders in Sweden : differentiating recidivists fromnon-recidivists in a 10-year follow-up study

Background: Forensic psychiatric patients present a challenge as they manifest severe mental disorders together with criminal behaviour. There are well-known risk factors for criminal behaviour in the general population, yet knowledge of what predicts reconviction in the Swedish forensic population in the long-term perspective is still insufficient. Aims: The study aims to (1) describe background

Concerns and quality of life before surgery and during the recovery period in patients with rectal cancer and an ostomy

PURPOSE: Rectal cancer is the most common reason for a person to undergo ostomy surgery. The aim of this study was to assess concerns and health-related quality of life (HRQOL) before surgery and during the first 6 months following ostomy surgery in the presence of rectal cancer.SUBJECTS AND SETTINGS: The sample comprised 57 patients at a university hospital in Gothenburg, Sweden. Their median age

Increased tree establishment in Lithuanian peat bogs — Insights from field and remotely sensed approaches

Over the past century an ongoing establishment of Scots pine (Pinus sylvestris L.), sometimes at accelerating rates, is noted at three studied Lithuanian peat bogs, namely Kerėplis, Rėkyva and Aukštumala, all representing different degrees of tree coverage and geographic settings. Present establishment rates seem to depend on tree density on the bog surface and are most significant at sparsely cov

Neighbourhood ethnic density and psychosis - Is there a difference according to generation?

Background: For different migrant groups living in an area with few people from the same ethnic background is associated with increased psychosis incidence (the ethnic density effect). We set out to answer the question: are there generational differences in this effect? Methods: Analysis of a population based cohort (2.2 million) comprising all those born 1st January 1965, or later, living in Denm

Factors influencing the skin exposure to diphenylguanidine in surgical gloves

Background: For health care personnelhandhygieneandwearing appropriate protective gloves are compulsory. We have noticed an increase of hand eczema caused by contact allergy from rubber chemicals such as diphenylguanidine (DPG) in synthetic rubber gloves used by surgeons and surgical nurses. The exposure time to surgical gloves as well as the number of gloves used per day vary. Furthermore surgery

HLA class II alleles specify phenotypes of ketosis-prone diabetes

OBJECTIVE - Ketosis-prone diabetes (KPD) comprises four subgroups based on the presence or absence of β-cell autoantibodies (A+ or A-) and β-cell functional reserve (β + or β-). Genetic factors could contribute to their distinctive phenotypes. Our aim was to specify the role of HLA class II alleles associated with susceptibility or resistance to autoimmune type 1 diabetes in determining KPD phenot

Equal prevalence of severe cervical dysplasia by HPV self-sampling and by midwife-collected samples for primary HPV screening : A randomised controlled trial

Objectives HPV self-sampling is an option for cervical screening. The aim of this randomised study was to investigate the compliance, prevalence of HPV, and prevalence of severe dysplasia in a vaginal self-sampling group in comparison to cervical samples collected by midwives (control arm). The hypothesis was that there would be no difference between vaginal self-sampling and cervical sampling to

Generation of anti-Notch antibodies and their application in blocking Notch signalling in neural stem cells

Notch signalling occurs via direct cell-cell interactions and plays an important role in linking the fates of neighbouring cells. There are four different mammalian Notch receptors that can be activated by five cell surface ligands. The ability to inhibit specific Notch receptors would help identify the roles of individual family members and potentially provide a means to study and control cell di