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Protein deletions are frequent among both disease-causing and tolerated variants. Several mechanisms at the DNA, RNA and protein levels can lead to deletions. Many deletions are misclassified in the literature and databases, especially when the mRNA is degraded by the cellular quality-control mechanism. We developed a novel predictor for sequence retaining protein deletions, i.e., variants that do
ADAR1 as a Therapeutic Target in Prostate Cancer Prostate cancer is the second most common cancer and a leading cause of cancer-related deaths in men. While early-stage prostate cancer can be managed effectively, once it spreads, treatment options are limited and usually not curative. Immunotherapy, which boosts the immune system to fight cancer, has been effective in some cancer types but not in
Robust and efficient target-tracking algorithms embedded on moving platforms, are a requirement for many computer vision and robotic applications. However, deployment of a real-time system is challenging, even with the computational power of modern hardware. As inspiration, we look to biological lightweight solutions-lightweight and low-powered flying insects. For example, dragonflies pursue prey
A large Danish family has previously been reported in which autosomal dominant frontotemporal dementia (FTD) is genetically linked to chromosome 3 (FTD-3). A mutation was recently identified in the CHMP2B gene that is probably responsible for causing disease in this family. Because of its neuropathologic findings, FTD-3 was originally categorized as a subtype of frontotemporal lobar degeneration,
All human practices are, ultimately, set and defined by limits; be they social, economic, physical, or environmental. Yet even in the face of such realities, practices which transgress the confines of possibility remain remarkably obdurate. This thesis addresses the issue of one such practice, i.e. the escalation of personal mobility across time and space which pushes above and beyond systemic bou
Wireless communication is evolving rapidly with ever more connected devicesand significantly increasing data rates. Since the invention of the smartphoneand the mass introduction of mobile apps, users demand more andmore traffic to stream music, watch high-definition video or to simply browsethe internet. This tremendous growth is more pronounced by the introductionof the Internet of Things (IoT)
Purpose: Since a distorted body experience and a sedentary lifestyle are central in the course of binge eating disorder (BED), physical therapy might be an interesting add-on treatment. The aim of this study was to systematically review randomised controlled trials (RCTs) evaluating physical therapy on binge eating and physical and mental health in BED patients. Method: EMBASE, PsycINFO, PubMed, C
The number of degrees of freedom (NDoF) in a communication channel fundamentally limits the number of independent spatial modes available for transmitting and receiving information. Although the NDoF can be computed numerically for specific configurations using singular value decomposition (SVD) of the channel operator, this approach provides limited physical insight. In this paper, we introduce a
Depression, ångest och stress är närliggande former av psykisk ohälsa som ofta uppvisar betydande symtomatisk överlappning. Föreliggande studie undersökte hur enskilda frågor inom självskattningsinstrumenten PHQ-9, GAD-7 och PSS-10 relaterade till respektive skala samt till varandra bland universitetsstudenter, med fokus på vilka frågor som framstod som mest centrala och indikativa för variation iDepression, anxiety, and stress are closely related forms of psychological distress that often exhibit substantial symptomatic overlap. The present study examined how individual items within the self-report instruments PHQ-9, GAD7, and PSS-10 were related to their respective scales as well as to each other among university students, with a focus on which items appeared most central and indicative
Many audio applications, including echo-cancellation and active noise control, rely on the availability of accurately estimated room impulse responses (RIRs). For these applications, it is common that the source signal is short and primarily consists of speech or music, which may cause the estimation of the RIR to be poorly conditioned. Although priors on the amplitudes of the RIR could in princip
As snow leopards (Panthera uncia) are vulnerable in the wild, individuals in captivity function as a backup for the wild population. However, space limitations make it difficult to keep the captive population healthy. To maintain high genetic diversity in the captive population, it is important to carefully consider breeding recommendations and the use of contraception. This study examined age-rel
This review aims to appraise and summarize the best available evidence from economic evaluations (EEs) of strategies targeting populations prior to a diagnosis of dementia. A comprehensive search was conducted in EMBASE, PubMed, EconLit, Web of Science, Cumulative Index to Nursing and Allied Health (CINAHL), and The NHS Economic Evaluation Database (NHS EED). Publications were dually screened and
Major efforts to develop antibody microarray technology to enable global proteome analysis to be performed in a facile manner are under way. In this process, the design and the properties of the substrate will play crucial roles. In the present study, we have developed novel, highly biocompatible solid supports for microarrays, using adsorbed recombinant human single-framework antibody fragments a
Troposfäriskt ozon - ett hot mot ekosystem, luftkvalitet och klimat MERGE POLICY BRIEF | 01 • 2013 2 MERGE POLICY BRIEF | 01 • 2013 Troposfäriskt ozon - ett hot mot ekosystem, luftkvalitet och klimat DAVID SIMPSON, SENIOR FORSKARE, NORSKE METEOROLOGISK INSTITUTT OCH CHALMERS Ozon är en gas som förekommer naturligt i atmosfären, men vars halt även påverkas av mänskliga aktiviteter. Det är både en l
https://www.cec.lu.se/sites/cec.lu.se/files/ozon_david_simpson_final.pdf - 2026-05-30
Spaceborne laser altimetry waveform estimates of canopy Gap Fraction (GF) vary with respect to discrete return airborne equivalents due to their greater sensitivity to reflectance differences between canopy and ground surfaces resulting from differences in footprint size, energy thresholding, noise characteristics and sampling geometry. Applying scaling factors to either the ground or canopy porti
Children spend a considerable part of their day in preschool, where they may be exposed to hazardous chemicals in indoor dust. In this study, brominated flame retardants (BFRs) and organophosphate esters (OPEs) were analyzed in preschool dust (n = 100) and children's hand wipe samples (n = 100), and diphenyl phosphate (DPHP) was analyzed in urine (n = 113). Here we assessed children's exposure via
Current global models of the carbon (C) cycle consider only vertical gas exchanges between terrestrial or oceanic reservoirs and the atmosphere, thus not considering the lateral transport of carbon from the continents to the oceans. Therefore, those models implicitly consider all of the C which is not respired to the atmosphere to be stored on land and hence overestimate the land C sink capability
Two in situ 'nanoreactors' for high-resolution imaging of catalysts have been designed and applied at the hard X-ray nanoprobe endstation at beamline P06 of the PETRA III synchrotron radiation source. The reactors house samples supported on commercial MEMS chips, and were applied for complementary hard X-ray ptychography (23 nm spatial resolution) and transmission electron microscopy, with additio
Introduction. Manual delineation of the left ventricle is clinical standard for quantification of cardiovascular magnetic resonance images despite being time consuming and observer dependent. Previous automatic methods generally do not account for one major contributor to stroke volume, the long-axis motion. Therefore, the aim of this study was to develop and validate an automatic algorithm for ti
