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To be able to survive in the long run the medical device industry of today needs effective development processes and ways to secure quality. These development processes and quality assurance processes must follow the different laws and regulations over the world depending on what market the organisations are established on. Organisations have been developing medical devices and systems over many y

The biogeography of speciation and what can be learned about the past mode of speciation from current biogeography of sister species are recurrent problems in evolution. We used a trait- and individual-based, eco-evolutionary model to simulate adaptive radiations and recorded the geographical overlap of species during and after evolutionary branching (speciation). We compared the spatial overlap a

Pheromone communication systems have a reliable signal with a restricted window of amounts and ratios released and perceived. We propose a model based on a Gaussian response profile that allows a quantification of the response peak (location of optimum) and a measure of the peak width (response window). Interpreting the Gaussian curve, fitted by nonlinear regression (NLR), as a standard normal dis

It has long been recognised that dispersal abilities and environmental factors are important in shaping invertebrate communities, but their relative importance for primary soil community assembly has not yet been disentangled. By studying soil communities along chronosequences on four recently emerged nunataks (ice-free land in glacial areas) in Iceland, we replicated environmental conditions spat

We present multiple-epoch radial-velocity observations for 104 stars in a field of the intermediate-age open cluster IC 4651 to . Only 13 stars (13%) of the full sample are field stars. From the 44 single member stars we find a mean radial velocity of , and the 12 single red-giant members yield a true radial-velocity dispersion of . Of the 19 giant members, 7 (37%) are spectroscopic binaries with

The Kaposi's, sarcoma-associated herpesvirus (KSHV) complement control protein (KCP) inhibits the human complement system, and is similar in structure and function to endogenous complement inhibitors. Other inhibitors such as C4d-binding protein and factor H, as well as the viral homologue vaccinia virus complement control protein are known to bind heparin and, for the two latter, also to glycosam

Background: As the incidence of allergy to different compounds increases in society, the need to understand and characterize specific IgE responses becomes F. obvious. Different cell culture systems have been evaluated for their ability to support such IgE secretion. Methods: One system employed human peripheral lymphocytes (PBL) from normal donors stimulated with anti-CD3 activated T cells with o

Popular Abstract in Swedish Fasoxidbränsleceller (eng. SOFC) är en keramisk bränslecellstyp som arbetar vid höga temperaturer. Genom att utnyttja energin hos avgaserna från en SOFC i en annan kraftvärmeprocess kan man erhålla ett s.k. hybridsystem som når höga verkningsgrader. Ett koncept som studerats i denna avhandling är en SOFC i kombination med en gasturbincykel (SOFC/GT). Eftersom bränslecelSolid oxide fuel cells (SOFCs) are a ceramic type of fuel cell operating at elevated temperatures. By utilising the thermal energy from the SOFC in a heat engine, a hybrid cycle with high performance can be achieved. One promising concept is a pressurised SOFC in combination with a recuperated gas turbine cycle. The fuel cell, being the more efficient power generator of the two, represents the maj

BackgroundDimethyl sulfoxide (DMSO) is essential for the preservation of liquid nitrogen-frozen stem cells, but is associated with toxicity in the transplant recipient. Study Design and MethodsIn this prospective noninterventional study, we describe the use of DMSO in 64 European Blood and Marrow Transplant Group centers undertaking autologous transplantation on patients with myeloma and lymphoma

In this article I show how aesthetic disciplines, to which musicology belongs, have suffered from a crisis of creativity for the past decade or so. By crisis of creativity I mean the development of new theories, which can contribute to new knowledge about music, from both historical and contemporary prespectives. With help from theories that normally lies outside of the institutional discourse of

This paper investigates the decision-making processes of mayors on the municipal level in Brandenburg, Germany, to support 100% renewable energy policies as well as the respective key success factors. Three different cases and their specific settings are examined: (1) Turnow-Preilack with Germany's largest solar power plant, (2) Prenzlau, a town claiming the title 'City of Renewable Energy’ and (3

Beta-blockers (bisoprolol, metoprolol succinate, carvedilol, and to some extent nebivolol), given on top of angiotensin-converting enzyme (ACE) inhibitors, improve survival and reduce morbidity in symptomatic stable chronic heart failure (CHF). Early beta-blockade may help to improve survival and especially prevent sudden death, but the usual practice of starting the ACE inhibitor first may lead t

Current market trends for industrial automation are the need for customizable production, shorter time to market, and powerful global competitive pressure. Based on these trends two challenges have been identified: 1) flexible production systems and 2) integration and utilization of devices and software. Applications from both process automation, manufacturing, and robotics have been considered.

Measurements in a road tunnel in Stockholm, Sweden give the real-world traffic emission factors for a number of gaseous and particle pollutants. These include 49 different polycyclic aromatic hydrocarbons (PAH), CO, NOX, benzene, toluene, xylenes, aldehydes, elements and inorganic/organic carbon contained in particles, the sub-micrometer aerosol number size distribution, PM2.5 and PM10. The exhaus

Background: Oxidation of LDL is associated with generation of autoantibodies against a large number of different aldehyde-modified peptide sequences in apo B-100. Autoantibodies recognizing peptide sequences in the LDL receptor-binding region of apo B-100 could potentially affect both cholesterol metabolism and atherosclerosis. The aim of the present study was to determine physiological effects of

Software release planning takes place on strategic and operational levels. Strategic release planning aims at assigning features to subsequent releases such that technical, resource, risk and budget constraints are met. Operational release planning focuses on the development of a single software release. Its purpose is to assign resources to feature development tasks such that total release durati

The rapid growth of traffic induced by Internet services makes the simple over-provisioning of resources not economical and hence imposes new requirements on the dimensioning methods. Therefore, the problem of network design with the objective of minimizing the cost and at the same time solving the tradeoff between maximizing the service data flows and providing fair treatment of all demands becom

According to Silvan Tomkins’ (1963, 1965) Polarity Theory, all ideologies are polarized by a fundamental conflict between Humanism, which idealizes and glorifies humanity, and Normativism, which portrays human beings as inherently worthless and able to attain value only through achievement of external norms. Research has shown that Humanism and Normativism do indeed form two coherent and negativel

Popular Abstract in Swedish Hudfibros, inre organengagemang och autoantikroppar vid systemisk skleros: longitudinell utveckling och effekt på överlevnad. Systemisk skleros kallas ofta för sklerodermi. Sjukdomen tillhör de systemiska bindvävssjukdomarna och handläggs i Sverige oftast av reumatologer. Kardinalsymtomet vid sklerodermi är förhårdnad hud vilket gett sjukdomen den dess namn. Sklero betySystemic sclerosis (SSc) is a connective tissue disease with a highly variable prognosis. Since new treatment strategies are emerging, there is a need for prognostic markers in order to help allocate patients to the optimal treatment. When comparison is made to the general population, there is an increased mortality rate in this study, both in the series as a whole and in the subgroups of men and

This study investigates the topic of forgiveness of sins in the mission of the historical Jesus. Gospel material that pertains to the question is authenticated by the use of criteria for historicity and interpreted within the wider context of first-century Judaism as part of a broader reconstruction of Jesus’ career as a healer and prophet. Questions posed and answered concern the historical plaus