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Wp11 2012

RESEARCH IN SERVICE STUDIES Working paper No 11, April 2012 The Department of Service Management Campus Helsingborg | Lund University NO ONE WANTS TO GET STUCK WITH THE LOSING CARD –The conditions of management in conjunction with hospital mergers Lars Nordgren, Lund University 1 No one wants to get stuck with the losing card - The conditions of management in conjunction with hospital mergers Lars

https://www.ses.lu.se/sites/ses.lu.se/files/wp11_2012.pdf - 2026-06-08

Body mass index and risk of malignant lymphoma in Scandinavian men and women

Background. The incidence of non-Hodgkin lymphoma and prevalence of obesity are increasing globally. A suggested positive association between obesity and risk of non-Hodgkin lymphoma has prompted us to investigate the relationship between body mass index (BMI) and risk of malignant lymphoma subtypes in a population-based case-control study. Methods: Telephone interviews were conducted with 3055 ca

Changes in body mass index following newly diagnosed type 2 diabetes and risk of cardiovascular mortality: A cohort study of 8486 primary-care patients

Aims. - Elevated body mass index (BMI) is associated with an increased risk of type 2 diabetes and cardiovascular disease (CVD). This study explored the association between BMI changes in the first 18 months of newly diagnosed type 2 diabetes and the risk of long-term CVD mortality. Methods. - A total of 8486 patients with newly diagnosed type 2 diabetes and no previous history of CVD or cancer we

CT lung densitometry in young adults with alpha-1-antitrypsin deficiency

Background: Severe (PiZZ) and moderate (PiSZ) alpha-1-antitrypsin (AAT) deficiency predispose to lung emphysema, especially in smokers. We hypothesized that multi-slice computed tomography (CT) might be superior to pulmonary function tests (PFT) to detect lung emphysema in AAT-deficient individuals at the age of 32 years. Methods: A subgroup of PiZZ and PiSZ individuals identified during the Swedi

Adjuvant therapy in primary GIST: state-of-the-art

The management of primary gastrointestinal stromal tumours (GISTs) has evolved with the introduction of adjuvant therapy. Recently reported results of the SSG XVIII/AIO trial by the Scandinavian Sarcoma Group (SSG) and the German Working Group on Medical Oncology (AIO) represent a significant change in the evidence for adjuvant therapy duration. The objectives of this European Expert Panel meeting

Evaluation of common variants in the six known maturity-onset diabetes of the young (MODY) genes for association with type 2 diabetes

An important question in human genetics is the extent to which genes causing monogenic forms of disease harbor common variants that may contribute to the more typical form of that disease. We aimed to comprehensively evaluate the extent to which common variation irk the six known maturity-onset diabetes of the young (MODY) genes, which cause a monogenic form of type 2 diabetes, is associated with

Quantification of insulin secretion in relation to insulin sensitivity in nondiabetic postmenopausal women.

To evaluate mechanisms underlying the close association between insulin secretion and insulin sensitivity, insulin sensitivity was evaluated by the euglycemic-hyperinsulinemic clamp technique (M/I(clamp)) and insulin secretion was determined from the 75-g oral glucose tolerance test (OGTT) and from the glucose-dependent arginine-stimulation test in 81 nondiabetic postmenopausal women, all aged 61

Alteration of the counterregulatory responses to insulin-induced hypoglycemia and of cognitive function after massive weight reduction in severely obese subjects

The autonomic nervous system (ANS) and hypothalamic-pituitary-adrenal (HPA) axis are reported as activated in excess in the morbidly obese state and, therefore, changes after weight loss can be anticipated. The aim of this study was to investigate the impact of a massive (similar to30%) weight reduction on the activation of the HPA axis and the ANS following bariatric surgery. Eight (7 women, 1 ma

Coagulation disturbances in the critically ill patient with special reference to prediction of outcome

Popular Abstract in Swedish Kritiskt sjuka patienter på intensivvårdsavdelningar (IVA) har ofta störningar i blodets levringsförmåga (koagulation). Kliniska tecken som blodpropp (djup ventrombos eller blodpropp i lungorna) och/eller blödning kan vara resultatet av aktivering och konsumtion av koagulationsfaktorer och koagulationshämmare. Disseminerad intravaskulär koagulation (DIC, som är en samtiCritically ill patients in intensive care units (ICU) often have coagulation disturbances. Clinical manifestations such as thromboembolism and/or bleeding may result from activation and consumption of coagulation factors and inhibitors. Disseminated intravascular coagulation (DIC) is a severe condition with an often-poor prognosis. Global haemostatic tests are inexpensive, widely available, and ma

Foreign Intervention in Internal Wars : The Case of the Nigerian Civil War 1967-70

Scholars of widely diverging persuasions have recognized the implications of the world constellation in which the discourse on foreign intervention with all its manifestations in a civil war has an explanatory value. How-ever, a number of long-standing theoretical, methodological and epistemological challenges still resist clearcut solution. This study analyzes the roles of the great powers and th

An integrated analysis of five double-blind, randomized controlled trials evaluating the safety and efficacy of a hyaluronan product for intra-articular injection in osteoarthritis of the kneel

Objective: Five double-blind, randomized, saline-controlled trials (RCTs) were included in the United States marketing application for an intra-articular hyaluronan (IA-HA) product for the treatment of osteoarthritis (OA) of the knee. We report an integrated analysis of the primary Case Report Form (CRF) data from these trials. Method. Trials were similar in design, patient population and outcome

Morbidity and mortality among foreign-born Swedes

Popular Abstract in Swedish Det svenska samhället har under senare delen av 1900-talet påverkats och förändrats på grund av en ökad internationell migration. År 1950 var 2,8 % av den svenska befolkningen utrikesfödd; idag utgör de utrikesfödda 12,0 % av totalbefolkningen. Om även andragenerationens migranter (de som har en eller båda föräldrar utrikesfödda) räknas med utgör första och andrageneratAims: The general aim of this thesis was to describe and compare the group of foreign-born persons living in Sweden and native Swedes with regard to health development over time, thus studying the influence of migration on health. Methods: All four studies are based on data from Statistics Sweden (SCB) and the National Board of Health and Welfare, Centre for Epidemiology covering the period 1970?

Patterns of systolic blood pressure response at the end of exercise and mortality and morbidity in patients referred for exercise testing

Objectives Peak exercise systolic blood pressure (SBP) is associated with future cardiovascular disease (CVD) and mortality. We aimed to evaluate the predictive value of different SBP patterns at the end of exercise with these outcomes. Methods We studied 6329 adults (45% women) referred for exercise testing, with test duration of 6-14 min, maximal effort and valid SBP measurements at the end of e

Risk of acute myeloid leukemia and myelodysplastic syndromes after multiple myeloma and its precursor disease (MGUS)

Using population-based data from Sweden, we identified all multiple myeloma (MM) patients (n = 8740) and 5652 monoclonal gammopathy of undetermined significance (MGUS) patients diagnosed between 1986 and 2005. We calculated standardized incidence rates (SIRs) for all subsequent hematologic and nonhematologic malignancies for MM patients diagnosed before/after 1995 (introduction of high-dose melpha

Do fall-risk-increasing drugs have an impact on mortality in older hip fracture patients? A population-based cohort study

Objective: The aim of this study was to assess the mortality in hip fracture patients with regard to use of fall-risk-increasing drugs (FRIDs), by comparing survival in exposed and nonexposed individuals. Design: This was a general population-based cohort study. Settings: Data on hip fracture patients were retrieved from three national databases. Participants: All hip fracture patients aged 60 yea

Effects of Cardiovascular drugs on Mortality in Severe Chronic Obstructive Pulmonary Disease A Time-Dependent Analysis

Rationale: Cardiovascular drugs may improve survival in chronic obstructive pulmonary disease (COPD). However, previous studies did not account for major sources of bias, and drug effects have not been evaluated in severe COPD. Objectives: To estimate the time-dependent effects of cardiovascular drugs on survival in oxygen-dependent COPD, accounting for immortal and immeasurable time bias. Methods

High lifelong relapse rate of psychiatric disorders among women with postpartum psychosis

Nager A, Szulkin R, Johansson S-E, Johansson L-M, Sundquist K. High lifelong relapse rate of psychiatric disorders among women with postpartum psychosis. Nord J Psychiatry 2013;67:53-58. Background: The relapse rate for psychiatric disorders after postpartum psychosis is high. Apart from subsequent puerperal periods, previous studies have not examined when relapses in psychiatric disorders occur.

Giant prolactinomas in women

Objective: To characterise distinctive clinical features of giant prolactinomas in women. Design: A multicentre, retrospective case series and literature review. Methods: We collected data from 15 female patients with a pituitary tumour larger than 4 cm and prolactin levels above 1000 mu g/l and identified 19 similar cases from the literature; a gender-based comparison of the frequency and age dis

Development of Protocols for Metabolomics in Biomedical Research using Chemometrics

Metabolomics is a rapidly growing research field. It aims for quantification of all the metabolites in a biological sample such as plasma, saliva, cerebrospinal fluid or cells. Because the metabolite levels in a biological sample are the end result of the regulatory processes in cells, metabolomics is a very powerful approach for characterisation of phenotypes. Metabolomics has been used to find d

To analyse measurements is to know!

Popular Abstract in Swedish Fjärrvärme är ett centraliserat uppvärmningssystem där varmt vatten distribueras i ett rörnätverk och används främst till byggnadsuppvärmning och för att värma varmvatten. Fjärrvärme finns i alla länder på norra halvklotet men har störst marknadsandel i Norden och Baltikum. I Sverige används fjärrvärme för att värma c:a 60% av all byggnadsyta. Två stora fördelar med fjäRenewable energy sources dominated the world energy supply until the beginning of the 20th century, when fossil energy became the dominant energy source worldwide. Today, fossil fuels contribute to over 80% of world energy supply. But there are two major reasons why fossil energy use has to stop. First, fossil energy is limited and will not last forever. Second, emissions of carbon dioxide change