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Ciliary neurotrophic factor (CNTF) promotes photoreceptor survival but also suppresses electroretinogram (ERG) responses. This has caused concerns about whether CNTF is detrimental to the function of photoreceptors because it is considered to be a potential treatment for retinal degenerative disorders. Here we report that the suppression of ERG responses is attributable to negative regulation of t
Gangliosides play important biological roles and structural characterization of both the carbohydrate and the lipid moieties is important. The FT-ICR MS/MS techniques of electron capture dissociation (ECD), electron detachment dissociation (EDD), and infrared multiphoton dissociation (IRMPD) provide extensive fragmentation of the protonated and deprotonated GM1 ganglioside. ECD provides extensive
Eight laboratories participated in a concerted research project on the assessment of hot working conditions. The objectives were, among others, to co-ordinate the work of the main European research teams in the field of thermal factors and to improve the methods available to assess the risks of heat disorders at the workplace, and in particular the “Required Sweat Rate” model as presented in Inter
BACKGROUND: Atypical antipsychotics have similar clinical efficacy in the treatment of schizophrenia; variability in their tolerability represents the discerning factor in treatment choices. Sertindole has a relatively good tolerability profile that favours long-term patient adherence and, therefore, is associated with lower rates of relapse and rehospitalization.AIM: A model was developed to comp
The global speed of change within the manufacturing industry forces companies to constantly improve production performance. In that effort, performance measures are critical for driving and managing production improvements. Two of the most commonly used measures in operations are productivity and overall equipment efficiency (OEE). However, the potential of using these measures as improvement driv
Cyanobacteria living epiphytically on mosses in pristine, unpolluted areas fix substantial amounts of atmospheric nitrogen (N) and therefore represent a primary source of N in N-limited boreal forests. However, the fate of this N is unclear, in particular, how the fixed N-2 enters the soil and becomes available to the ecosystem. In this study, we applied N-15-ammonium chloride (N-15-NH4Cl) onto ca
Introduction: Arterial spin labelling (ASL) is a non-invasive magnetic resonance imaging (MRI) technique for assessment of perfusion. ASL uses magnetically labelled blood water as a diffusible endogenous tracer to measure the perfusion of brain tissue, i.e. the cerebral blood flow (CBF). Traditionally, ASL samples images at a specific point in time allowing the CBF to be calculated using a model o
Based on the hedonic pricing method, this paper investigates the way in which room rates are determined. I identify ten significant room rate determinants in the Swedish capital city of Stockholm. Two separate models for double rooms are estimated; one for the business week and one for the weekend. Initially, nineteen variables were considered, but since nine of them were shown to be jointly redun
Water availability faces increasing pressure due to economic growth, population growth,greater affluence as well as climate change. For companies, this could lead to higher businessrisks as water is often a key ingredient in their operations for example in cooling, steamgeneration and cleaning. Moreover, companies might be competing over water with otherstakeholders in the region when water scarci
Testicular germ cell cancer is preceded by a pre-invasive stage called carcinoma-in-situ (CIS). The majority, if not all cases of CIS will progress into invasive cancer. Today, the only reliable way of diagnosing CIS is by performing open testicular biopsy. There is an ongoing search for non-invasive techniques for diagnosing early testicular neoplasia. The possibility of using ultrasound of the t
Lipase from Penicillium roquefortii immobilized on porous polypropylene particles was used for enzymatic preparation of 1,2-diglycerides by alcoholysis in organic media. A screening of commercially available lipases showed that lipases from Penicillium species produced high amounts of 1,2-diglycerides from triglycelirles. Reaction parameters such as solvent, alcohol, water activity, and fatty acid
Early Vascular Aging (EVA): New Directions in Cardiovascular Protection brings together the last decade of research related to the characterization of EVA, as well as the predictive power of pulse wave velocity (PWV). The book presents a novel approach to the problem of cardiovascular disease, showing it in relation to great vessels disease and revealing a comprehensive approach to the problem of
The objective of this study has been to create an online system for condition monitoring and diagnosis for a combined heat- and power plant in Sweden. This system consists of artificial neural network models, representing each main component of the combined heat- and power plant, accompanied with a graphical user interface. The artificial neural network models are integrated on a power generation
The EU-funded project European Cultural Heritage Online (ECHO) aims to integrate resources from various domains within the field of cultural heritage, and make them available on the Internet. To accomplish this integration it is necessary to describe the various resources in a way that will achieve cross-domain interoperability. This description of digital resources is commonly referred to as
This essay is devoted to quite a special form of investment - venture capital. More precisely the purpose is to map out, describe and analyse the most fundamental parts of investment protection in connection with venture capital investments. Venture capital is part of the market of risk capital, which refers to investments occuring on the receipt of, or possibility to receive ownership in a compan
Background: The Evaluation in Ayres Sensory Integration ® (EASI) is a performance-based assessment tool, aiming to assess sensory perception, sensory reactivity, postural/ocular/bilateral integration, and praxis in children aged 3–12 years. These types of tests are currently not available in Swedish. A structured, multistep process of translation is crucial for maintaining equivalence between the
Even when the editor of the popular journal Populär Arkeologi claims to be communicating the latest advances in archaeological research to the public and that the authors often are professional archaeologists, this is done very rarely and focuses mostly on dating and artifacts. Is it the editor’s responsibility or must the archaeologists themselves highlight these issues in their articles? Common
A reduced kinetic mechanism for methanol combustion at spark-ignition (SI) engine conditions is presented. The mechanism consists of 18 species and 55 irreversible reactions, small enough to be suitable for large eddy simulations (LES). The mechanism was reduced and optimized using the comprehensive mechanism (AramcoMech 2.0) as a starting point, to maintain performance at stoichiometric condition
The study estimates greenhouse gases generated bysuburban housing companies with the use of a hybrid LCAmodel where IO-LCA methodology is used together withprocess data. The aim of the research was to learn whichactivities associated with housing companies generate mostgreenhouse gases, as well as by whom the emissions could bediminished. In addition, the applicability of hybrid life cycleassessme
