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Complement analysis in the clinic is usually associated with the quantification of C3 and C4, measurement of C1-inhibitor and screening for complement activity. These analyses have been available in routine diagnostic laboratories for decades. In recent years, however, the field of complement analysis has expanded considerably, with the introduction of novel assays to detect complement activation
It is of central interest in membrane proteomics to establish methods that combine efficient solubilization with enrichment of proteins and intact protein complexes. We have investigated the quantitative and qualitative solubilization efficiency of five commercially available detergents using mitochondria from the yeast Saccharomyces cerevisiae as model system. Combining the zwitterionic detergent
The selective blockade of alpha1-adrenoceptors (ARs) is now a well-accepted and widely used treatment for patients presenting with lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH) and bladder outlet obstruction. The sites of action of the currently used alpha1-AR antagonists when relieving LUTS have not yet been established, but it seems clear that effects on
Coreceptor use was determined for human immunodeficiency virus type 1 (HIV-1) isolates of various subtypes from 11 women during pregnancy and their infected children. Isolates from peripheral blood mononuclear cells (n = 79) and from plasma (n = 59) were available. The clinical and immunological stages of HIV-1 infection were recorded. Coreceptor use was tested on human cell lines expressing CD4 a
Mechanisms controlling microbial degradation of dissolved organic matter (DOM) in aquatic environments are poorly understood, although microbes are crucial to global nutrient cycling. Bacterial cell wall components may be one of the keys in understanding the presence of slowly degrading DOM in nature. We found that dominant components of bacterial cell walls (D-amino acids (D-AA), glucosamine (Glu
Two different relatively simple, commercially available supercritical fluid extractors (SFE), Leco and Foss-Tecator, were tested for the determination of total fat content in meat and meat products. The fatty acid composition in meat and meat products was also determined after the Foss-Tecator extraction in an aliquot of the extract. Total fat was determined by weighing after the different extract
As today’s market forces the implementation of quality-of-service-enabled services spanned over multiple administrative domains, isolated and locally optimized interdomain routing decisions become increasingly inadequate. Instead, coordinated routing models are required together with joint optimization goals. Available papers and standardization documents focus on the description of technical mean
Detailed mineral magnetic measurements were carried out on three varved lake-sediment sequences in Sweden, which extend to ca. 7000 BC. The comparison of the magnetic properties of the organic rich varved lake-sediments with their respective catchment materials indicates that the magnetic properties of the sediments are dominated by relatively high concentrations of single-domain magnetite magneto
A multimodal approach to nondestructive seismic pavement testing is described. The presented approach is based on multichannel analysis of all types of seismic waves propagating along the surface of the pavement. The multichannel data acquisition method is replaced by multichannel simulation with one receiver. This method uses only one accelerometer-receiver and a light hammer-source, to generate
In this study 158 children, 80 children with diabetes mellitus and 78 healthy classmates, were interviewed about their concept of different types of illness (a cold, diabetes, infection, the most and least serious disease) and illness-related concepts (pain, becoming ill and going to the doctor or hospital). Special attention was given to the relationship between development of thinking and the va
A simple labeling approach is presented based on protein expression in [1-C-13]- or [2-C-13]-glucose containing media that produces molecules enriched at methyl carbon positions or backbone C-alpha sites, respectively. All of the methyl groups, with the exception of Thr and Ile(delta 1) are produced with isolated C-13 spins (i.e., no C-13-C-13 one bond couplings), facilitating studies of dynamics
Shibanqiao Reservoir (0.24 km(2)) and Xiaohe Reservoir (0.28 km(2)) have catchments of 6.00 km(2) and 22.69 km(2), respectively. They essentially represent "strongly eroded" (Shibanqiao) and "mildly eroded" (Xiaohe) regions in Guizhou Plateau, southwestern China. Sediment cores were retrieved from the two reservoirs and soils were also sampled from their catchments. Mineral magnetic measurements w
Presently there is no neuroprotective pharmacological treatment of proven clinical safety and efficacy available. The purpose of this study was to investigate whether the ss-carboline, abecarnil (Abe), which has already passed clinical phase III trials in patients with anxiety disorders, is neuroprotective in in vitro models of cerebral ischemia or excitotoxicity. Abe (100 nM) protected cultured c
Cytoplasmic protein-tyrosine kinases (PTKs) are enzymes involved in transducing a vast number of signals in metazoans, The importance of the Tec family of kinases was immediately recognized when, in 1993, mutations in the gene encoding Bruton's tyrosine kinase (Btk) were reported to cause the human disease X-linked agammaglobulinemia (XLA).((1,2)) Since then, additional kinases belonging to this f
Niemann-Pick disease type C (NP-C) is a lysosomal storage disease in which impaired intracellular lipid trafficking leads to excess storage of cholesterol and glycosphingolipids in the brain and other tissues. it is characterized clinically by a variety of progressive, disabling neurological symptoms including clumsiness, limb and gait ataxia, dysarthria, dysphagia and cognitive deterioration (dem
Popular Abstract in Swedish I allt större grad har effektivitetsbegreppet kommit i fokus i samhällsomvandlingen. I huvudsak utgår vi från att effektivitet i första hand är liktydigt med ekonomisk effektivitet. Existensen av en slags övergripande, ekonomisk "rationalitet", tas för given och har närmast karaktären av naturlag eller central, samhällelig grundbult. Under det senaste decenniet har omfaThe study takes as its starting point the far-reaching organizational changes that have occurred within the public sector in Sweden, particularly the public health care sector, during the last decade. The aim of achieving efficacy has been an important driving force in these processes, which often concern mergers or reductions in personnel that are regarded as a route to success. Paradoxically, Sw
Indoor positioning is recognized as one of the upcoming major applications which can be used in wide variety of applications such as indoor navigation and enterprise asset tracking. The significance of localization in indoor environments have made the use of Wi-Fi based indoor positioning so that it can utilize available current wireless infrastructure and perform positioning very easily. In this
Today, it is common knowledge in the cyber-physical systems domain that the tight interaction between the cyber and physical elements provides the possibility of substantially improving the performance of these systems that is otherwise impossible. On the downside, however, this tight interaction with cyber elements makes it easier for an adversary to compromise the safety of the system. This beco
Evaluation of recommender systems is an actively discussed topic in the recommender system community. However, some aspects of evaluation have received little to no attention, one of them being whether evaluating recommender system algorithms with single-number metrics is sufficient. When presenting results as a single number, the only possible assumption is a stable performance over time regardle
