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Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with neither a known cause nor an available cure. With disease progression, toxic protein aggregates form in the brain, leading to the loss of the upper and lower motor neurons. While circulating bone marrow-derived inflammatory cells have not been shown to cross the blood brain barrier, changes in their number and comp

Den 1 juli 2021 blev det straffbart att låta barn bevittna brott mellan närstående. Brottet fick rubriceringen ”barnfridsbrott” och återfinns i 4 kap. 3 § BrB. Kriminaliseringen av att låta barn bevittna brott mellan närstående bemöttes av positiv respons från de flesta remissinstanserna. Trots att barnfridslagen välkomnades med öppna armar fanns en viss oro för hur lagens utformning skulle fungerOn the first of July, 2021, it became a crime in Sweden to allow children to witness crimes between relatives. The crime is called ”barnfridsbrott” and exists in Chapter 4, Section 3 in the Swedish Criminal Code. The criminalization of allowing children to witness crimes between relatives was met with a positive response from most of the consultation bodies. Although it was welcomed with open arms

Aim: This qualitative study explores the sexual and reproductive health service provision offered to undocumented Roma women migrating to Finland and traces the major challenges in this regard through the experiences, the perceptions, and the views of Finnish health professionals. Background: Sexual and reproductive health (SRH) of undocumented Roma women is of a particular concern since the lack

Gender roles and constructions of ideals have long imposed unrealistic expectations on people to behave in certain ways and even be certain types of people. Women, more so, than others. Ideals of womanhood, what it means to be a woman, a good woman, a new woman, have required women to perform who they are at all times. The imaginary of the “New Woman” is only of these ideals that has been around g

Hedersrelaterat våld och förtryck blev känt i Sverige under 1990-talet, då de första uppmärksammade hedersmorden begicks i landet. Morden på Sara, Pela och Fadime väckte stor debatt i Sverige och man försökte hitta förklaringar till hur detta kunde inträffa och framförallt varför. Hedersrelaterat våld skiljer sig från andra våldsformer mot kvinnor på ett flertal sätt. Det som är viktigt att framHonour-related violence and oppression became known in Sweden during the 1990s, when the first high-profile honour murders were committed in the country. The murders of Sara, Pela and Fadime raised an intensive debate in Sweden and we tried to find explanations for how this could have happened, and above all why. Honour-related violence differs from other forms of violence against women in severa

Aggrecan (ACAN) is localized in the intervertebral disc (IVD) in unique compartment-specific patterns where it contributes to the tissue structure and mechanical function together with collagens. The extracellular matrix (ECM) of the IVD undergoes degenerative changes during aging, misuse or trauma, which inevitably alter the biochemical and biomechanical properties of the tissue. A deeper underst

Background: Pharmaco-mechanical thrombolysis (PMT) has emerged as a treatment option in patients with acute lower limb ischemia (ALI), especially Rutherford IIb (motor deficit) for rapid revascularization, but supportive data is scarce. The aim of the present study was to compare the effects of thrombolysis, complications, and outcomes of PMT first versus catheter-directed thrombolysis (CDT) first

BACKGROUND: Fatigue is a distressing and prevalent long-term sequela of treatment for childhood cancer, and there is a need for longitudinal studies to investigate the development of fatigue over time. The objective of this study was to calculate growth-curves for the longitudinal development of fatigue after treatment for childhood cancer, and to investigate the effects of biopsychosocial predict

Introduction: Individuals with type 2 diabetes (T2D) are at high risk of experiencing atherosclerotic cardiovascular disease (ASCVD), which is associated with morbidity, mortality and healthcare resource utilisation. Clinical guidelines recommend the use of glucose-lowering medications with cardiovascular benefits in individuals with T2D and cardiovascular disease, but there is evidence that this

Numerous studies have demonstrated the significant impact of the resolution of solar irradiation data on the outcomes of hourly production models. Accurate integration of photovoltaic (PV) systems sometimes demands a high-resolution global horizontal irradiance (GHI) time series to capture the rapid fluctuations in PV power output induced by swift irradiance changes. Most of the available database

The study of plant mitochondria started in earnest around 1950 with the first isolations of mitochondria from animal and plant tissues. The first 35 years were spent establishing the basic properties of plant mitochondria and plant respiration using biochemical and physiological approaches. A number of unique properties (compared to mammalian mitochondria) were observed: (i) the ability to oxidize

Purpose: Examine the association between circulating lipids and breast cancer outcomes in patients enrolled in the Malmö Diet and Cancer Study (MDCS). Patients and methods: Circulating lipid levels were measured in blood sampled upon enrollment in the female MDCS cohort (N = 17,035). We identified all MDCS participants with incident invasive breast cancer diagnosed between 1991 and 2014. Follow-up

A new generation of octahedral iron(ii)-N-heterocyclic carbene (NHC) complexes, employing different tridentate C^N^C ligands, has been designed and synthesized as earth-abundant photosensitizers for dye sensitized solar cells (DSSCs) and related solar energy conversion applications. This work introduces a linearly aligned push-pull design principle that reaches from the ligand having nitrogen-base

Aim: To evaluate the incidence of chromosomal aberrations in apparently isolated ventricular septal defects (VSD), quantify the timing of diagnosis of prenatally diagnosed VSDs, and define the spontaneous closure rate prenatally both in utero and during the first year of life. Materials and methods: Medline, PubMed, and the Cochrane Database Library were searched to identify studies published betw

People living in urban and industrialized societies, which are expanding globally, spend more than 90% of their time in the indoor environment, breathing indoor air (IA). Despite decades of research and advocacy, most countries do not have legislated indoor air quality (IAQ) performance standards for public spaces that address concentration levels of IA pollutants. Few building codes address opera

BACKGROUND: Diagnostic testing is essential for disease surveillance and test-trace-isolate efforts. We aimed to investigate if residential area sociodemographic characteristics and test accessibility were associated with Coronavirus Disease 2019 (COVID-19) testing rates.METHODS: We included 426 224 patient-initiated COVID-19 polymerase chain reaction tests from Uppsala County in Sweden from 24 Ju

Brazil's Atlantic Forest biome is one of the world's biodiversity hotspots, whose heterogeneous ecosystems are threatened by habitat loss and climate change. Palaeoecological research can provide essential context for the impacts of anthropogenic climate change in the 21st Century and beyond, but existing studies have notable limitations in the insights they can provide: vegetation proxy data are

Background Exertional breathlessness is a key symptom in cardiorespiratory disease and can be quantified using incremental exercise testing, but its prognostic significance is unknown. We evaluated the ability of abnormally high breathlessness intensity during incremental cycle exercise testing to predict all-cause, respiratory, and cardiac mortality. Study design and methods Longitudinal cohort s