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The fields of human genetics and genomics have generated considerable knowledge about the mechanistic basis of many diseases. Genomic approaches to diagnosis, prognostication, prevention and treatment – genomic-driven precision medicine (GDPM) – may help optimize medical practice. Here, we provide a comprehensive review of GDPM of complex diseases across major medical specialties. We focus on tech
BACKGROUND: Knowledge is scarce on how needs for home help and special housing evolve among older people who begin to receive support from municipal social care. The purpose of this study was to describe baseline distributions and transitions over time between levels of dependency among older persons after being granted social care in a Swedish municipality.METHODS: Based on a longitudinal cohort
Pulse wave velocity is an established marker of early vascular aging but may also help identifying individuals with supernormal vascular aging. We tested the hypothesis that individuals with the largest difference (Δ-age) between chronological and vascular age show the lowest rate of cardiovascular events and may thus be defined as supernormal vascular aging. Vascular age was defined as the predic
Scholarly journals are often blamed for a gender gap in publication rates, but it is unclear whether peer review and editorial processes contribute to it. This article examines gender bias in peer review with data for 145 journals in various fields of research, including about 1.7 million authors and 740,000 referees. We reconstructed three possible sources of bias, i.e., the editorial selection o
Cesium copper halides Cs3Cu2X5 (X = Cl, Br, and I) have attracted much attention for optoelectronic applications because of their self-trap excitons and high photoluminescence quantum yield. Intrinsic point defects play a critical role in the optoelectronic performance of these materials by affecting fundamental properties, such as carrier mobility, lifetime, and recombination rate. In this work,
Mouse plasmacytomas induced by pristane oil alone, or in combination with Abelson murine leukemia virus (A-MuLV), regularly carry one of three alternative chromosomal translocations that juxtapose c-myc to immunoglobulin heavy- or light-chain loci. E mu-c-myc transgenic mice develop translocation-free plasmacytomas after induction by pristane oil and/or A-MuLV [Sugiyama, H., Silva, S., Wang, Y., W
The concept of smart specialization has attracted great interest and has been adopted widely in European regional and innovation policy. Foresight is an important part of creating smart specialization strategies. However, both the smart specialization concept and foresight have been criticized for lacking an empirical and theoretical foundation that can help guide their application in practice. Th
The concept of smart specialization has attracted great interest and has been adopted widely in European regional and innovation policy. Foresight is an important part of creating smart specialization strategies. However, both the smart specialization concept and foresight have been criticized for lacking an empirical and theoretical foundation that can help guide their application in practice. Th
1 INTRODUCTION In a global and highly competitive economy, companies have now adopted an increasingly integrated ap-proach to product development. However, packaging logistics has been left out from this integration trend. The reasons are multiple: first packaging is not considered to be an integral part of the product, so it is not part of the product “culture” of the company. In most companies,
Try to imagine a fire emergency evacuation. What is the first image that you have in your mind? Here there are some guesses. Probably a parent running inside a house trying to rescue her children, but not managing since she is too scared? An old man stuck crying in a corner of a room with flames and smoke all around him? Or a group of people crushing aggressively against each other in order to get
This thesis consists of four self-contained, yet related articles which all contribute mainly to the corporate governance literature. Very broadly, the first two papers are on family firms and large shareholders in Sweden while the second two are on Enterprise Risk Management (ERM) practices in Nordic countries. The contribution of Paper 1 is that I for the first time take into account the two dim
This dissertation focuses primarily on the following aspects concerning music in theatre: 1) its experienced peculiarity – ontologically grounded, 2) its sounding scope, and 3) its various kinds of functions. I argue that the difference between spoken theatre and opera is a question of degree rather than essence, and consider such an assertion being especially valid for the music of these genres.
The Global Energy Assessment (GEA) brings together over 300 international researchers to provide an independent, scientifically based, integrated and policy-relevant analysis of current and emerging energy issues and options. It has been peer-reviewed anonymously by an additional 200 international experts. The GEA assesses the major global challenges for sustainable development and their linkages
Combining the strengths of an advanced mathematical model of human physiology and a thermal manikin is a new paradigm for simulating thermal behaviour of humans. However, the forerunners of such adaptive manikins showed some substantial limitations. This project aimed to determine the opportunities and constraints of the existing thermal manikins when dynamically controlled by a mathematical model
Popular Abstract in Swedish Nollvisionen antagen av Sveriges riksdag fastlägger att ingen skall behöva dödas eller skadas svårt i trafiken i Sverige. Införande av detta begrepp förskjuter fokus från trafikolyckorna till konsekvenserna av trafikolyckorna och härmed skapas förutsättningar för ett paradigmskifte i trafiksäkerhetsarbetet. För att åstadkomma önskade förändringar är det nödvändigt och bThe over-arching objectives of this thesis were to formulate a method to describe the consequences of traffic casualties, and to explain the influence of different traffic engineering factors on these consequences for society and individuals over time. A more detailed objective was to examine whether available short-term indicators can be used to predict consequences in a long-term perspective. Ot
OBJECTIVE: To determine if power Doppler ultrasound examination of the endometrium can contribute to a correct diagnosis of endometrial malignancy in women with postmenopausal bleeding and endometrium >/= 5 mm. METHODS: Eighty-three women with postmenopausal bleeding and endometrium >/= 5 mm underwent gray-scale and power Doppler ultrasound examination using predetermined, standardized settings. S
The empirical focus of this article is technological innovation activities in the emerging field of fuel cells and related hydrogen technology in Norway from 1990 to 2002. In this period, four comparatively large-scale research and development projects and a number of smaller projects aimed at development of fuel cells technology were undertaken, resulting in many inventions that were subsequently
