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Cyclic and congenital neutropenia are caused by mutations in the human neutrophil elastase (HNE) gene (ELA2), leading to an immunodeficiency characterized by decreased or oscillating levels of neutrophils in the blood. The HNE mutations presumably cause loss of enzyme activity, consequently leading to compromised immune system function. To understand the structural basis for the disease, we implem
AIM: The present study examines the association between parity and survival following breast cancer diagnosis. METHODS: Medical records of 4453 women diagnosed with breast cancer in Malmö, Sweden, between 1961 and 1991 were analysed. All women were followed until 31 December 2003, using the Swedish Cause-of-Death Registry. Breast cancer specific mortality rate was calculated in different levels of
Background: Spontaneous bacterial peritonitis (SBP), which has been reported to be present in 10-30% of patients with cirrhotic ascites, may easily be overlooked. An important aim of our study was to determine whether there are any clinical signs which, in clinical practice, may predict or exclude SBP. Methods: We studied 133 patients with cirrhotic ascites from medical units at nine Swedish unive
During the last 10 years, an increasing number of genes have been identified whose abnormalities account for primary immunodeficiencies, with defects in development and/or function of the immune system. Among them is the JAK3,gene, encoding for a tyrosine kinase that is functionally coupled to cytokine receptors which share the common gamma chain. Defects of this gene cause an autosomal recessive
We describe the sequence and extent of the complex and little understood post-juvenile and post-breeding moults of Savi’s Warblers Locustella luscinioides. In contrast to previous studies, the post-juvenile moult occurred in at least 44% of the birds, 5% of which moulted some or all tertials and greater coverts. The timing of overlap between the filling and the post-juvenile moults, and the fact t
The four-electron reduction of dioxygen to water in multicopper oxidases takes place in a trinuclear copper cluster, which is linked to a mononuclear blue copper site, where the substrates are oxidized. Recently, several intermediates in the catalytic cycle have been spectroscopically characterized, and two possible structural models have been suggested for both the peroxy and native intermediates
Mental disorders are associated with premature mortality, and the magnitudes of risk have commonly been estimated using hospital data. However, psychiatric patients who are hospitalized have more severe illness and do not adequately represent mental disorders in the general population. We conducted a national cohort study using outpatient and inpatient diagnoses for the entire Swedish adult popula
Understanding the molecular programs of the generation of human dopaminergic neurons (DAn) from their ventral mesencephalic (VM) precursors is of key importance for basic studies, progress in cell therapy, drug screening and pharmacology in the context of Parkinson's disease. The nature of human DAn precursors in vitro is poorly understood, their properties unstable, and their availability highly
Decrease of the human brain temperature was induced by intranasal cooling. The main purpose of this study was to compare the two magnetic resonance methods for monitoring brain temperature changes during cooling: phase-difference and magnetic resonance spectroscopic imaging (MRSI) with high spatial resolution. Ten healthy volunteers were measured. Selective brain cooling was performed through nasa
Gas turbines are widely used for aircraft propulsion, land-base power generation, and other industrial applications like trains, marines, automobiles, etc. To satisfy the fast development of advanced gas turbines, the operating temperature must be increased to improve the thermal efficiency and output work of the gas turbine engine. However, the heat transferred to the turbine blade is substantial
Cholesterol is an essential membrane component enriched in plasma membranes, growth cones, and synapses. The brain normally synthesizes all cholesterol locally, but the contribution of individual cell types to brain cholesterol metabolism is unknown. To investigate whether cortical projection neurons in vivo essentially require cholesterol biosynthesis and which cell types support neurons, we have
Bakgrund: Tio procent av kvinnorna i Sverige lever med endometrios som kan leda till svåra smärtor och påverkad livskvalitet. Syfte: Att undersöka hur aktiviteter i hemmet upplevs av kvinnor som lever med endometrios. Metod: Nio kvalitativa intervjuer genomfördes med kvinnor som lever med endometrios. Datan analyserades genom kvalitativ innehållsanalys. Resultat: Det övergripande temat var; utfBackground: Ten percent of women in Sweden are living with endometriosis, which can lead to severe pain and affect life quality. Aim: How activities in the home are experienced by women living with endometriosis. Method: Nine qualitative interviews were conducted with women living with endometriosis. Data was analyzed through qualitative content analysis. Results: The overall theme was; The per
Syftet med denna studie var att göra en systematisk litteraturstudie genom att undersöka tio RCT-studier om traumarelaterad skam och PTSD. Syftet var att identifiera i vilken utsträckning KBT-behandlingar effektivt kan behandla skam relaterad till traumaincidenter, och även hur skam har behandlats i studier av traumabehandling. De undersökta studierna använde olika KBT-behandlingar och studerade oThe aim of this study was to make a systematic literature study by examine ten RCT studies regarding trauma-related shame and PTSD. The aim was to identify to what extent CBT-treatments would effectively treat shame arisen from trauma incidents, and also regarding how shame has been treated in studies of trauma treatment. The examined studies used different CBT-treatments and studied different pop
This thesis proposes a method for how to find duplicated 3D points in a single Structure from Motion point cloud. Together with related articles, this forms a possible solution to the loop closure problem. The proposed method works by first selecting candidate pairs of 3D points by comparing BRIEF descriptors of all points. The second step consists of using RANSAC to select the best out of many
Sverige ämnar bygga sina höghastighetsbanor som beräknas vara i drift 2035. Höghastighetsnätet löser kapacitetsproblemet i framtiden, Sveriges miljö-och klimatmål kräver mer järnväg och höghastighetsnätet kan öka tillgängligheten till möjliga arbeten inom 45 min restid (SJ u.å.). Många orter som ligger i närheten av den förslagna höghastighetsbanan önskar att ingå i höghastighetsnätet. De höga inSweden intends to build its high-speed railways, which are expected to be operational by 2035. The high-speed network solves the capacity problem in the future. Sweden's environmental and climate goals require more rail and the high-speed network can increase access to possible jobs within 45 minutes of travel time (SJ u.å.). Many cities that are close to the proposed high-speed railway wish
Taking Action on Human Rights in Sierra Leone's Prisons - The Raoul Wallenberg Institute of Human Rights and Humanitarian Law Skip to content Search for: Search Button Home About Us Who We Are Our History About Raoul Wallenberg Our Theory of Change Staff Opportunities Annual Reports Whistleblower Our work What we do Multi-Disciplinary Research Higher Education Strategic Advice and Analysis Outreac
https://rwi.lu.se/2017/05/24/taking-action-human-rights-sierra-leones-prisons/ - 2026-07-10
A product with the need for a wireless communication between itself and a smartphone will be developed. A suitable wireless protocol and module will be chosen and evaluated. How should the software be designed? What functions should be available? In the end the module and software will be tested in the field to see how it works in reality. For the choosing of protocol, the following will be discus
Abstract Accusations of sexual assault are very disputed in today’s society. It is a sensitive subject which deserves to be treated with respect, since the alleged crimes are of a dire nature. Since the rise of the social movement #MeToo, women all over the world have shared their experiences of sexual assault. It has resulted in many famous men being publicly accused. These women have been publ
