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Popular Abstract in English The secondary metabolites found in plants represent an extremely rich and limitless source of novel chemical diversity for drug discovery. In fact, some of the most important drugs currently in use today are derived from plants and they were discovered as a result of the study of medicinal plants used in traditional medicine. In this context, Bolivia is one of the most In response to the challenges of their local environments, organisms produce of a large number of chemical diverse compounds with complex stereochemistry and reactive functional groups. These characteristics enable them to interact and bind specifically to biological target molecules and exert various biological activities, and have assured that Natural products continues to be an important source

Background: Risk gene variants for celiac disease, identified in genome-wide linkage and association studies, might influence molecular pathways important for disease development. The aim was to examine expression levels of potential risk genes close to these variants in the small intestine and peripheral blood and also to test if the non-coding variants affect nearby gene expression levels in chi

BACKGROUND: Hypothermia may be accidental or therapeutic. Therapeutic hypothermia is increasingly used as treatment for various conditions, e.g., neuroprotection after cardiac arrest. Hypothermia leads to an impairment of the coagulation system, but the degree of impairment has been difficult to determine. Most studies have been performed on plasma instead of whole blood. We therefore evaluated wh

Stroke causes life long disabilities where few therapeutic options are available. Using electrical and magnetic stimulation of the brain and physical rehabilitation, recovery of brain function can be enhanced even late after stroke. Animal models support this notion, and housing rodents in an enriched environment (EE) several days after experimental stroke stimulates lost brain function by multise

Anthropogenic land-use covers a constantly increasing fraction of the terrestrial surface area. By employing a dynamic global vegetation model, human-induced changes in the terrestrial water balance as compared to an undisturbed scenario were simulated. The results suggest that humanity is a main driver of change in the terrestrial water balance in general and green water in particular. Most strik

The aim of this study was to examine how social workers working with the Staircase Model and Housing First can help long-term homeless people with a long history of alcohol and/or drug abuse, their view of the models and how they describe and use their discretion. I used a qualitative method and data was gathered by semi-structured interviews. I interviewed five social workers in four different mu

The dopamine transporter (DAT) is responsible for dopamine (DA) clearance in the synaptic cleft, and thus crucial for maintaining DA homeostasis in the central nervous system (CNS). Mutations in the DAT coding gene have been associated with both movement and psychiatric disorders, such as parkinsonism and attention-deficit hyperactivity disorder (ADHD). However, the detailed contribution of DAT in

Syftet med förevarande uppsats är att belysa umgängessabotage och dess eventuella konsekvenser. Närmare bestämt avses att undersöka hur ett eventuellt umgängessabotage påverkar tingsrätten i sin bedömning när den har att ta ställning till vad som innebär barnets bästa (se föräldrabalken 6 kap. 2 a §). Umgängesrätten har utvecklats från att vara en rättighet avsedd för den förälder som utan grund hThe purpose of this essay is to highlight the consequences of the situation where one parent without acceptable cause refuses the other parent’s right of access with their child, hereinafter called ‘access sabotage’. The purpose is more specifically to investigate how the situation of access sabotage is affecting the district court in its assessment when it has to consider what outcome will be in

Purpose: Using both a theoretical and empirical perspective, we investigate if the credit derivative market is efficient or not. Method: We have used a qualitative method. A survey has been sent to 23 major banks and investment banks with questions about the credit derivative market and how the efficiency work in the market. The answers have been adapted to different efficiency theories to help re

The purpose of this rapport is to assess the safety of ROS Care & Service. An assessment is made and suggestions is given about how the safety level may be increased. The main focus is on evacuation safety. Floor 4 section C has been chosen to symbolize all sections in the newest part of the building. By investigating likely fire scenarios, calculating when hazardous criteria’s for these scena

Towards a New Eldercare? Middle managers reflections on how to create good service within homes for the elderly. [translated title] For the past twenty years there has been a governing trend of efficiency and privatization of the swedish elder care. These trends have put the elder cares very foundation, it’s purpose, in a tremble. Middle managers within the swedish elder care are struggling to

Lagstiftaren har gjort bedömningen att barn i åldrarna 15-17 år bör skyddas från vissa sexuella handlingar och därför har man kriminaliserat köp av sexuell handling av barn. För att ansvar ska kunna utkrävas måste gärningspersonen ha uppsåt ifråga om alla omständigheter utom barnets ålder, där måste denne endast agerat oaktsamt. Enligt 6:13 BrB kan en person dömas för köp av sexuell handling av ba

On 22 January 2015, the ECB finally announced its expanded asset repurchase programme, better known as quantitative easing (ECB, 2015c). In this thesis, we are examining the effect of this announcement on sovereign bond yields in the Eurozone using the event study methodology and by time series forecasting (ARMA). We are particularly interested to see if there have been some abnormal variations (i

The European Union is often portrayed as a soft, civilian power. In this thesis we question this view of the Union, by comparing it to the United States of America; usually described as a hard power user. We compare the foreign policy actions of the EU and the US in the seventeen conflicts of 2004. With help from K. J. Holsti's division of strategies to exercise power we create our own tool fo

The formation of industry standards for environmental issues and corporate social responsibility is gaining acceptance but the number of successfully implemented programs are few. On an individual level companies have for some time applied company standards or codes of conduct. But on a collective level cooperation seems much more difficult. Although from an economic point of view there are clear

Almost all businesses, in today’s market, builds on complex supply chains operating on the global market. The competition is no longer between individual companies but between different supply chains. This creates new risks for both the individual company and the companies operating in the supply chain. Cooperation between small and medium sized business partners can create possibilities and high