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Background: In order to get global molecular understanding of one of the most important crop diseases worldwide, we investigated compatible and incompatible interactions between Phytophthora infestans and potato (Solanum tuberosum). We used the two most field-resistant potato clones under Swedish growing conditions, which have the greatest known local diversity of P. infestans populations, and a r
Road verges can support high densities of flowers and could therefore provide new opportunities for the conservation of flower-visiting insects. One way of optimizing road verges for vascular plant diversity is to adjust mowing regimes, but to date it is unclear how this affects flower-visiting insects. Furthermore, for mobile organisms like wild bees and butterflies, there is a risk that the bene
Background and objective: The treatment landscape of metastatic prostate cancer (mPCa) has evolved significantly over the past two decades. Despite this, the optimal therapy for patients with mPCa has not been determined. This systematic review identifies available predictive models that assess mPCa patients’ response to treatment. Methods: We critically reviewed MEDLINE and CENTRAL in December 20
In a systematic examination of scales commonly used in L2 Motivational Self System (L2MSS) research, Al-Hoorie et al. (2024) found discriminant validity problems. Raising jangle fallacy concerns, they argue that substantive research should be paused until validity issues are ironed out. However, validity at the measurement level is dependent on validity at the construct level. Replication attempts
This study aimed to experimentally examine how riverbed drying and different rates of water level reduction influenced the vertical movement of amphipods of various sizes into different subsurface sediment compositions. Using sediment columns (mesocosms) filled with different sized transparent substrates, we explored how varying speeds of drawdown affected vertical movement and stranding of indivi
Housing of animals in an enriched environment (EE) has many positive effects on brain structure and function and can facilitate recovery from various brain injuries. The purpose of this study was to evaluate whether enriched rearing could alter the stress response induced by repeated immune challenge and to investigate the influence of EE and immune challenge on glutamate receptor gene expression
OBJECTIVE: The main objective of this study was to investigate possible predictors of response to cholinesterase inhibitor (ChEI) treatment, including pre-treatment progression rates and levels of the cerebrospinal fluid (CSF) biomarkers. A secondary objective was to evaluate whether treatment with ChEI changed progression. METHODS: Out-patient individuals (n = 191) with the clinical diagnosis of
Increased intraocular pressure (IOP) is a major risk factor for glaucoma, and its contribution to neuronal damage appears multi-factorial. An open issue is whether pressure effects on blood vessels contribute to neuronal damage. In particular, little is known about pressure effects on capillaries, which are the site of most metabolic exchange in the retina, but cannot be easily visualized in vivo.
PURPOSE: Leukemic stem cells (LSCs) may harbor important resistance to tyrosine kinase inhibitors in chronic myeloid leukemia (CML). We identified Philadelphia chromosome (Ph) positive CD34+CD38- bone marrow cells (here denoted LSCs) and addressed their response-predictive value in CML patients (n=48) subjected to nilotinib in the ENEST1st trial (NCT01061177).EXPERIMENTAL DESIGN: Two flow cytometr
The islet amyloid polypeptide (IAPP), a pancreas-produced peptide, has beneficial functions in its monomeric form. However, IAPP aggregates, related to type 2 diabetes mellitus (T2DM), are toxic not only for the pancreas, but also for the brain. In the latter, IAPP is often found in vessels, where it is highly toxic for pericytes, mural cells that have contractile properties and regulate capillary
Strategisk kommunikation har länge förföljts av ryktet att vara omoraliskt, ofta använt synonymt med nedsättande ord som sofistik och propaganda. Forskare inom samhällsvetenskapen har tränats att acceptera denna beskrivning av strategisk kommunikation som en normativ utgångspunkt, genom inflytelserika teorier som Habermas diskursetik och metodologier som kritisk diskursanalys. Denna avhandling utmStrategic communication has long suffered from a reputation of immorality, often being conflated with derogatory terms such as sophistry and propaganda. Scholars in the social sciences have been trained to accept this moralizing idea of strategic communication as a normative point of departure, through influential theories such as Habermas’ discourse ethics and methodological approaches such as cr
Factors behind intraspecific variation in sensitivity to pathogens remain poorly understood. We investigated how geographical origin in two North European amphibians affects tolerance to infection by the chytrid fungus Batrachochytrium dendrobatidis (Bd), a generalist pathogen which has caused amphibian population declines worldwide. We exposed newly metamorphosed individuals of moor frog Rana arv
Circulating mitochondrial DNA (mtDNA) is receiving increasing attention as a danger-associated molecular pattern in conditions such as autoimmunity, cancer, and trauma. We report here that human lymphocytes [B cells, T cells, natural killer (NK) cells], monocytes, and neutrophils derived from healthy blood donors, as well as B cells from chronic lymphocytic leukemia patients, rapidly eject mtDNA a
Designing building form in urban areas is a complicated process that demands considering a high number of influencing parameters. On the other hand, there has been an increasing trend to design highly fenestrated building envelopes for office buildings to induce higher levels of natural lighting into the workspace. This paper presents a novel optimization framework to design high-performance build
In an experimental study of humans reactions to social motor intention (SMI) in a humanoid robot, we showed that SMI cause the emergence of social interaction between human and robot. We investigated whether people would respond differently to a humanoid robot depending on the kinematic profile of its movement. A robot placed a block on a table in front of a human subject in three different ways.
The purpose of the study is to investigate the impact, in magnitude and direction, of some preliminary push-pull economic forces on the decision of Finland people to migrate to Sweden in the time period 1960-2009. It also aims to see how different people respond to those forces active based on their sex, marital status and age, 15-30 and 50-65 and strives to oversee which economic factors were mor
A considerable number of studies on historical and some third world populations have reached a magnificent consensus that both mortality and fertility do respond to economic changes in a surprisingly shared pattern. Such response, however, remains a great deal of controversy, obscure and inconsistency in the secular industrialized countries. The aim of this paper is to explore the association betw
