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Basic helix-loop-helix PAS domain proteins form a growing family of transcription factors. These proteins are involved in the process of adaptation to cellular stresses and environmental factors such as a change in oxygen concentration. We describe the identification and characterization of a recently cloned PAS domain protein termed Npas4 in ischemic rat brain. Using gene expression profiling fol

We have seen that protein kinase Calpha (PKCalpha) is transiently translocated to the plasma membrane by carbachol stimulation of neuroblastoma cells. This is induced by the Ca2+ increase, and PKCalpha does not respond to diacylglycerol (DAG). The unresponsiveness is dependent on structures in the catalytic domain of PKCalpha. This study was designed to investigate if and how the kinase activity a

Artikeln utgör en respons till ett föredrag om Derridas rättvisebegrepp, hållet av den isländske filosofen Björn Thorsteinson.

This article is a response to Greenbank's (2006) The academic's role: the need for a re-evaluation? It is also a contribution to the ongoing debate about the need to develop a broader view of scholarship and the different activities related to it such as 'teaching', 'research' and 'service to the community'. Arguments related to current research are presented to enhance a deeper understanding and

The traditional family unit has historically been considered a fundamental element of Vietnamese society. Despite legislation which has declared the equality of men and women, in reality, household gender roles remain fixed and often unequal, and family members are not expected to deviate from the norm. Men hold the dominant position within the household, and the belief that the husband can legiti

Introduction: Dystonia-deafness syndrome is a distinct clinical presentation within the dystonia-spectrum. Although several genetic and acquired causes have been reported, etiology remains unknown in the majority of patients. Objectives: To describe two patients with dystonia-deafness syndrome due to a beta-actin gene mutation. Methods: We report on disease course, genetic testing, and management

With the aim of clarifying critical care nursing, six critical care nurses, working in a Swedish intensive care unit (ICU) were each asked to narrate a care situation with which they had been satisfied or dissatisfied. The stories were tape-recorded and analysed using a phenomenological-hermeneutic approach inspired by the philosophy of Ricoeur. The themes uncovered in the analysis describe the nu

Introduction Lactate concentration in umbilical cord blood is an important measure of intrapartum anaerobic metabolism. The aim of the study was to compare lactate production of large‐for‐gestational‐age (LGA) fetuses against appropriate‐for‐gestational‐age (AGA) fetuses during hypoxia, in diabetic and non‐diabetic mothers. Material and methods A total of 17 358 validated paired arterial and ve

Osteoporosis often leads to fragility fractures of the hip, resulting in impaired quality of life and increased mortality. Augmenting the proximal femur could be an attractive option for prevention of fracture or fixation device failure. We describe a tissue engineering based strategy to enhance long-term bone formation in the femoral neck of osteoporotic rats by locally delivering bioactive molec

The complexity of microwave heating stems to a large extent from the intrinsic complexity of the materials exposed to microwave irradiation. For simple ideal homogeneous material, its size, shape and orientation with respect to the electromagnetic field influence the microwave absorption properties at the macroscopic scale. Furthermore, a number of material parameters, namely the complex permittiv

Disturbances play a key role in forest dynamics globally, with various effects on productivity. Tree diversity is expected to attenuate the negative impact of disturbance on forest productivity, but its overall effect has been little explored and might depend on the functional composition. Here, we analysed whether forest productivity responses to disturbances were modulated by structural and func