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By virtue of their undisputed role in allergy, the study of airway mast cells has focused on nasal and bronchial mast cells and their involvement in allergic rhinitis and asthma. However, recent mechanistic and human studies suggest that peripheral mast cells also have an important role in asthma, as well as chronic obstructive pulmonary disease, respiratory infections and lung fibrosis. Pathogeni
The prediction of transcription factor binding sites in genomic sequences is in principle very useful to identify upstream regulatory factors. However, when applying this concept to genomes of multicellular organisms such as mammals, one has to deal with a large number of false positive predictions since many transcription factor genes are only expressed in specific tissues or cell types. We devel
We recently finemapped a type 1 diabetes (T1D)-linked region on chromosome 21, indicating that one or more T1D-linked genes exist in this region with 33 annotated genes. In the current study, we have taken a novel approach using transcriptional profiling in predicting and prioritizing the most likely candidate genes influencing beta-cell function in this region. Two array-based approaches were use
X-linked retinitis pigmentosa (XLRP) is a severe form of inherited progressive retinal degeneration. The RP3 (retinitis pigmentosa type 3) locus at Xp21.1 is believed to account for the disease in the majority of XLRP families. Linkage analysis and identification of patients with chromosomal deletion have refined the location of the RP3 locus and recently have led to the cloning of the RPGR (retin
The dynamic soil model SAFE was calibrated and validated in a small hardwood forest of southern Quebec as a function of its ability to reproduce current soil chemistry and similar pre-industrial soil conditions despite the difference in forest history. SAFE was relatively accurate for reproducing soil chemistry, but comparison of pre-industrial soil conditions between unburned and burned stands ca
The reactivity of the phosphine-thioether ligands bis(2-diphenylphosphino) ethylthio)ethane (PSSP), bis(2-(diphenylphosphino) ethyl)sulfane (PSP), PPh2CH2CH2SMe (PS), PPh2(o-C6H4SMe (PortoS), and PPh(o-C6H4SMe)2 (PSS) towards low-valent carbonyl clusters has been studied. In all structurally characterized clusters, the ligand donor atoms are terminally coordinated. The phosphine-thioether ligands
In today’s world, the growing use of solar photovoltaic (PV) systems especially in the logistics sector has provided companies with new opportunities to produce renewable energy, improve their sustainability performance, and reduce carbon emissions from their operations. Importantly, the deployment of solar systems also helps contribute to broader environmental goals such as the European Green Dea
COSB30 Schedule and readings 1 Course Outline COSB30: China Today 31 October 2022 to 15 January 2023 Course Convener Stefan Brehm Contact: stefan.brehm@ace.lu.se Teachers: Stefan Brehm, Tabita Rosendal Ebbesen, Gina Song Lopez, Marina Svensson, Jinyan Zeng Lecture 1: Introduction and political system (Marina), 31 October, 13.15 – 15.00 Joseph, William A. (ed.) (2019). Politics in China: An Introdu
https://www.ace.lu.se/sites/ace.lu.se/files/2022-10/COSB30%20Schedule%20and%20readings.pdf - 2026-07-17
Global pollinator populations are declining. One of the causes is land use change, which results in reduced flower resources in the landscape. Bumblebees have small stores of nectar and pollen and are therefore vulnerable to loss of flower resources. I test if forbs plantings, which enhance forage resources, can support colony development and reproductive success of bumblebee colonies in Californi
The meeting between public life in the city and our private bodily needs creates sensitive and complex architectural challenges, and public toilets are a clear example. They are often seen as merely practical and technical spaces, but they also reveal how a city thinks about accessibility, safety, and equality. How can these places meet basic needs while still feeling safe, clean, and welcoming? A
Formerly widely distributed throughout Europe, the great snipe (Gallinago media) – a medium-sized wader species – has experienced an important decline in the last century, mainly driven by habitat loss. Remaining population are now restricted to eastern Europe and Scandinavia and the species is considered endangered. The great snipe (Gallinago media) is a food specialist, feeding almost exclusivel
Permanent Temporality explores how urban design can actively engage with time—not as a constraint, but as a creative and structural element. This thesis applies the concept to long-term development, using temporary interventions as catalysts for lasting urban transformation. These interventions foster community engagement and activate spaces throughout the development process. The Mälarporten area
Raoul Wallenberg Institute of Human Rights and Humanitarian Law #198E2, Street 51, corner Street 370, BKK1, Chamkarmon, Phnom Penh, Cambodia | Phone +85598 531 405 Call for Applications: Regional Human Rights Research Initiative As part of its Capacity Development Programme in Cambodia 2013-2017, the Raoul Wallenberg Institute of Human Rights and Humanitarian Law (RWI) hereby calls for application
https://rwi.lu.se/app/uploads/2015/02/Invitation-Call-for-Application.pdf - 2026-07-17
This paper investigates whether a City Scan Procedure (CSP) can be developed into a value enhancing and economically acceptable solution to make cultural tourismsustainable. The purpose of developing CSP into an established method is both to relieve stressed tourist destinations with strong anti-tourist reactions via site relocations and that its revenues primarily accrues to the host country, thu
We have investigated the implications of the recent crystallographic findings that the m2-bridging S2B sulfide ligand may reversibly dissociate from the active-site FeMo cluster of nitrogenase. We show with combined quantum mechanical and molecular mechanical (QM/MM) calculations that once S2B has dis- sociated, N2 may bind in that position and can be protonated to two NH3 groups by thermodynamica
The nature of the Neolithic Pitted Ware Culture (PWC) has been debated in Scandinavian archaeology since the beginning of the 20th century. This material culture post-dates the inception of an agro-pastoral Neolithic economy in the region (TRB) but demonstrate a semi-foraging lifeway. The PWC is considered elusive in the sense that the economy has been interpreted as either based on maritime forag
Abstract. This study presents a comprehensive assessment of the meteorological conditions and atmospheric flow during the Lagrangian-type "Hill Cap Cloud Thuringia 2010" experiment (HCCT-2010), which was performed in September and October 2010 at Mt. Schmücke in the Thuringian Forest, Germany and which used observations at three measurement sites (upwind, in-cloud, and downwind) to study physical
While general trends in Central European postglacial recolonisation dynamics are relatively well known, we often lack studies on intermediate (meta-population, landscape) scales. Such studies are needed to increase our understanding of, for example, the location of refugia; emergence of endemism, rates and trajectories of postglacial migrations; and anthropogenic landscape changes. Here, we focuse
Rising temperatures can influence ecosystem processes both directly and indirectly, through effects on plant species and communities. An improved understanding of direct versus indirect effects of warming on ecosystem processes is needed for robust predictions of the impacts of climate change on terrestrial ecosystem carbon (C) dynamics. To explore potential direct and indirect effects of warming
Molecular data sets for phylogenetic inference continue to increase in size, especially with respect to the number of genes sampled. As more and more genes are included in analyses, the importance of partitioning the data to avoid problems that can arise from underparameterization becomes more apparent. With an eight-gene data set from 38 metalmark moth species (12 genera represented) and three ou
