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Background: Patients with non-small cell lung cancer (NSCLC) harboring a ROS proto-oncogene 1 (ROS1)-rearrangement respond to treatment with ROS1 inhibitors. To distinguish these rare cases, screening with immunohistochemistry (IHC) for ROS1 protein expression has been suggested. However, the reliability of such an assay and the comparability of the antibody clones has been debated. Therefore we e
Background: Early blight, caused by the necrotrophic fungal pathogen Alternaria solani, is an economically important disease affecting the tuber yield worldwide. The disease is mainly controlled by chemical plant protection agents. However, over-using these chemicals can lead to the evolution of resistant A. solani strains and is environmentally hazardous. Identifying genetic disease resistance fa
Most recent programming languages, such as Java, Python and Ruby, include a collection framework as part of their standard library (or runtime). The Java Collection Framework provides a number of collection classes, some of which implement the same abstract data type, making them interchangeable. Developers can therefore choose between several functionally equivalent options. Since collections hav
The diverse, largely Neotropical subtribe Euptychiina is widely regarded as one of the most taxonomically challenging groups among all butterflies. Over the last two decades, morphological and molecular studies have revealed widespread paraphyly and polyphyly among genera, and a comprehensive, robust phylogenetic hypothesis is needed to build a firm generic classification to support ongoing taxono
The burden of cardiometabolic diseases is increasing worldwide. Early detection of high-risk individuals is essential for appropriate diagnosis, better treatment outcomes, quality of life and lower health related costs. Aims: The overall aim of this thesis is to investigate the possible associations between plasma proneurotensin (Pro-NT) and risk of cardiovascular disease (CVD), type 2 diabetes (T
Objective: To investigate the effects of fever therapy compared with no fever therapy in a wide population of febrile adults. Design: Systematic review with meta-analyses and trial sequential analyses of randomised clinical trials. Data sources: CENTRAL, BIOSIS, CINAHL, MEDLINE, Embase, LILACS, Scopus, and Web of Science Core Collection, searched from their inception to 2 July 2021. Eligibility cr
Objective: To assess the association between achievement of prostate-specific antigen (PSA) levels ≤0.2 ng/mL (henceforth ‘ultralow’) and clinical outcomes in patients in the ‘Targeted Investigational Treatment Analysis of Novel Anti-androgen’ (TITAN) study (ClinicalTrials.gov Identifier NCT02489318) with metastatic castration-sensitive prostate cancer (mCSPC). Patients and Methods: Patients in th
BackgroundThe use of stereotactic body radiotherapy (SBRT) to definitively treat oligometastases in prostate cancer has drawn large clinical and research interests within radiation oncology. However, the evidence is considered in its early stages and there is currently no systematic review of randomized controlled trials (RCTs) in this field. We aimed to evaluate the efficacy and safety of SBRT as
This bookThis book has become the leading source for empirical software engineering research through its earlier editions. It provides an in-depth introduction to experimentation in software engineering. The focus is on the steps to go through to conduct an experiment. It also introduces a structure for selecting a research design and an introduction to systematic literature reviews, surveys, and
Background: Well-developed vocabulary skills are crucial for academic success. Students having the language of instruction as a second language and students from lower socioeconomic backgrounds often have lower performance on vocabulary assessments. Teachers play an important role in supporting the vocabulary development of all students, regardless of background and educational needs.Aims: To inve
Background: The diagnostic accuracy of digital breast tomosynthesis (DBT) and digital mammography (DM) in breast cancer screening may vary per breast density subgroup. The purpose of this study was to evaluate which women, based on automatically assessed breast density subgroups, have the greatest benefit of DBT compared with DM in the prospective Malmö Breast Tomosynthesis Screening Trial. Materi
In a world where copyright is being infringed in a plethora of ways, consumers find it difficult to access legal digital content. Therefore, this thesis investigates how copyright law governs access to legal content in the digital environment in respect of so-called consumptive use. By apprehending a user-centric approach I evaluate whether and how copyright law accounts for the consumer interest
Background: Patients with bladder pain syndrome experience debilitating pain and extreme frequency of urination. Numerous therapeutic approaches have been tested, but as the molecular basis of disease has remained unclear, specific therapies are not available. Objective: Recently, a systematic gene deletion strategy identified interleukin-1 (IL-1) hyperactivation as a cause of severe cystitis in a
BACKGROUND: Individuals with multiple islet autoantibodies are at increased risk for clinical type 1 diabetes and may proceed gradually from stage to stage complicating the recruitment to secondary prevention studies. We evaluated multiple islet autoantibody positive subjects before randomisation for a clinical trial 1 month apart for beta-cell function, glucose metabolism and continuous glucose m
Human activity is constantly causing environmental problems due to production and release of numerous chemicals. A group of compounds of special concern is persistent organic pollutants (POP). These toxic, lipophilic chemicals have a high chemical and biological stability, and tend to accumulate in the lipid phase of living organisms. A major sink for POPs are sediments, and consequently these are
BACKGROUND AND PURPOSE: The aim of the study was to determine the prevalences of carotid artery disease and major and minor potential cardioembolic sources (1) in patients with cerebral infarction and age-matched control subjects and (2) in different clinical subtypes of cerebral infarction. METHODS: A series of 166 consecutive patients with cerebral infarction and 59 control subjects was examined
Rome in Sweden? The Catholic Offensive in Ecumenical-National Context Since World War II, ecumenical principles have been used as historical measures. This has led to re-interpretations of historical events and to alterations of sources, for example the letters and diaries by Elisabeth Hesselblad, the renewer of St. Birgitta’s order. In the literature on the Swedish Archbishop Nathan Söderblom, th
This doctoral dissertation studies voltage controlled oscillators (VCOs) that operate at low supply voltages. Due to smaller transistor sizes and lower supply voltage ratings with every new CMOS technology, voltage headroom is diminishing. Therefore, new ways to build VCOs and quadrature VCOs (QVCOs) have been sought to overcome this smaller headroom, while still maintaining the high performance o
Decision-makers and managers spend substantial amounts of funding everyday on various interventions aimed at management of the large carnivores, for example different measures to mitigate depredation on livestock, e.g., removal of carnivores and fencing of livestock (see Linnell et al. 1996 for an extensive review). Management of species that occur in low numbers is challenging as relatively small
