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Purpose: With modern treatments, mantle cell lymphoma (MCL) patients more frequently experience long-lasting remission resulting in a growing population of long-term survivors. Follow-up care includes identification and management of treatment-related late-effects, such as secondary malignancies (SM). We conducted a population-based study to describe the burden of SM in MCL patients. Methods: All
PACs (polycylic aromatic compounds) are air pollutants formed in incomplete combustion, e.g., in vehicle engines. Vegetation can potentially remove substantial amounts and act as bioindicators of these pollutants. Increased knowledge of the pollutant removal efficiencies of different tree species is essential for understanding the potential benefits trees can provide urban residents. We investigat
Background: Metabolic positron emission tomography/computed tomography (PET/CT) parameters describing tumour activity contain valuable prognostic information, but to perform the measurements manually leads to both intra- and inter-reader variability and is too time-consuming in clinical practice. The use of modern artificial intelligence-based methods offers new possibilities for automated and obj
Background: Paleolithic Diet Fraction (PDF) and Paleolithic Diet Score (PDS) are both measures of how closely a food intake conforms to a Paleolithic dietary pattern. PDF is calculated directly from an individual’s absolute food intake and PDS is an aggregated score based on an individual’s food intake relative to a population. Both are inversely associated with all-cause and cause-specific mortal
Environmental loads, such as wind and river flow, play an essential role in the structural design and structural assessment of long-span bridges. Climate change and extreme climatic events are threats to the reliability and safety of the transport network. This has led to a growing demand for digital twin models to investigate the resilience of bridges under extreme climate conditions. Kalix bridg
Since the Industrial Revolution, human activities have elevated atmospheric CO2 concentrations. The consequences of this include rising temperatures, shifts in precipitation patterns, and increased intensity and frequency of extreme weather events, such as heat waves and droughts. Elevated temperatures can accelerate microbial activity in soil, potentially resulting in an increased rate of soil
Background: The complex management of health needs in multimorbid patients, alongside limited cost data, presents challenges in developing cost-effective patient-care pathways. We estimated the costs of managing 171 dyads and 969 triads in Belgium, taking into account the influence of morbidity interactions on costs. Methods: We followed a retrospective longitudinal study design, using the linked
Background & aim: Clinical trials supplementing the long-chain polyunsaturated fatty acids (LCPUFAs) docosahexaenoic acid (DHA) and arachidonic acid (AA) to preterm infants have shown positive effects on inflammation-related morbidities, but the molecular mechanisms underlying these effects are not fully elucidated. This study aimed to determine associations between DHA, AA, and inflammation-r
The use of digital technologies to deliver primary health care has increased over the past decade. While some technologies have been shown to be medically effective and efficient, the effects of digital primary care on the policy goal of equality in the use of such types of care have not been studied using large register data. The aim of this study was to analyse how digital contacts differ from o
Wind damage is one of the most economically and ecologically significant natural disturbances in European forests, yet the cloud cover that follows major storms routinely blocks optical satellite acquisitions for weeks, precisely when rapid damage mapping is most valuable. Synthetic aperture radar (SAR) circumvents this limitation through all-weather imaging, but pixel-level windthrow detection fr
Neuroinflammation is associated with l-DOPA treatment in Parkinson's disease (PD), suggesting a role in l-DOPA-induced dyskinesia (LID), however it is unclear whether increased inflammation is specifically related to the dyskinetic outcome of l-DOPA treatment. Diversely from oral l-DOPA, continuous intrajejunal l-DOPA infusion is associated with very low dyskinetic outcome in PD patients. We repro
Omvärderingsregeln, som är en mervärdesskatterättslig regel, infördes i svensk rätt 2008 för att kunna motverka skatteundandragande och skatteflykt vid tillhandahållanden mot felaktig ersättning mellan personer som är förbundna med varandra. Den situation som identifierats som vanligast är att tillhandahållanden sker mot en för låg ersättning när tillhandahållaren har full avdragsrätt för mervärdeThe reevaluation rule, which is a VAT-related rule, was introduced into Swedish law in 2008 to counteract tax evasion and tax avoidance in transactions when incorrect compensation between connected persons are made. The situation identified as most common is that transactions occur for too low compensation when the provider has full deduction rights for VAT and the purchaser wholly or partially la
Multiple stressors affect the Baltic Sea, such as eutrophication, deoxygenated water and pollution. Almost all stres- sors are heightened or caused by anthropogenic impact. The stressors effect has increased since the beginning of the industrialisation and increased many of the stressors. The area of interest for this thesis is Bornholmsgattet, an area located between Sweden and the Island of Bor
The COVID-19 crisis introduced telecommuting and distance schooling into households all around the world. When national authorities enforced mitigation measures, they not only limited the spread of the disease, but also altered the lifestyle of many people. The joint effect of millions of people adapting to the new reality gave rise to an altered residential energy consumption pattern. Knowledge a
Popular Abstract in Swedish Avhandlingen är en granskning av ett antal psykologiska metoder i syfte att förbättra bedömning/diagnostik av två olika tillstånd förknippade med kontakt med kemikalier: (1) kronisk nedsättning av hjärnfunktion till följd av långvarig kontakt med lösningsmedel i yrket (toxisk encefalopati, förkortat TE), och (2) överkänslighet för kemikalielukter av okända orsaker (eng.The dissertation deals with psychological methods aimed at improving the understanding and assessment of two disorders related to contact with chemicals: solvent-induced chronic toxic encephalopathy (TE) and multiple chemical sensitivity (MCS). The main aim of Paper I was to study whether the addition of some newer psychological tests of complex attention and executive functions to a traditional
Adsorption of cationic polyelectrolytes onto polystyrene latices was studied as function of polymer chemical composition and molecular weight, polymer and surface charge density and ionic strength. The ratio between polymer charges and surface charges was close to one when distances between polymer and surface charges were equal. Overcompensation of the surface charge was obtained at higher polyme
Bone and soft tissue tumors (BSTT) belong to a diverse group of solid tumors of mesenchymal origin, with a large number of histological types affecting individuals of all ages. The general aim of the present thesis (Articles I-V) was to investigate in detail the genetic aberrations in selected subtypes of benign and malignant BSTT. Aberrations identified by chromosome banding analysis were studied
This thesis examines the creative appropriation of Shakespeare in theory and practice. It is based on close readings of King Lear alongside three appropriations of the play in works of fiction by three North American women writers: Jane Smiley, Anne Tyler, and Margaret Atwood. The aim is to demonstrate how a ‘palimpsestic’ reading, i.e. a reading in which the reader oscillates between ‘pre-text’ a
Purpose: To investigate whether increased fluctuation of intraocular pressure (IOP) is an independent factor for glaucoma progression. Design: A cohort of patients was followed up in a randomized clinical trial. Participants: Two hundred fifty-five glaucoma patients from the Early Manifest Glaucoma Trial (EMGT; 129 treated and 126 control patients). Methods: Study visits, conducted every 3 months,
Objective. To evaluate the performance of biochemical and traditional markers in predicting radiographic progression in rheumatoid arthritis (RA). Methods. One hundred thirty-two patients with early RA were treated with nonbiologic therapies for 2 years and studied longitudinally. Genomic DNA was analyzed for presence of the shared epitope. Levels of matrix metalloproteinases (matrix metalloprotei
