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Therapeutic advances using targeted biologicals and small-molecule drugs have achieved significant success in the treatment of chronic allergic, autoimmune, and inflammatory diseases particularly for some patients with severe, treatment-resistant forms. This has been aided by improved identification of disease phenotypes. Despite these achievements, not all severe forms of chronic inflammatory and
Randomised controlled trials are increasingly conducted as embedded, nested, or using cohorts or routinely collected data, including registries, electronic health records, and administrative databases, to assess if participants are eligible for the trial and to facilitate recruitment, to deliver an embedded intervention, to collect trial outcome data, or a combination of these purposes. This repor
Atherosclerosis is a major underlying cause of cardiovascular disease. Previous studies showed that inhibition of the co-stimulatory CD40 ligand (CD40L)-CD40 signaling axis profoundly attenuates atherosclerosis. As CD40L exerts multiple functions depending on the cell-cell interactions involved, we sought to investigate the function of the most relevant CD40L-expressing cell types in atheroscleros
Differences by sex in lung cancer incidence and mortality have been reported which cannot be fully explained by sex differences in smoking behavior, implying existence of genetic and molecular basis for sex disparity in lung cancer development. However, the information about sex dimorphism in lung cancer risk is quite limited despite the great success in lung cancer association studies. By adoptin
Objectives: To develop EULAR recommendations for screening and prophylaxis of chronic and opportunistic infections in patients with autoimmune inflammatory rheumatic diseases (AIIRD). Methods: An international Task Force (TF) (22 members/15 countries) formulated recommendations, supported by systematic literature review findings. Level of evidence and grade of recommendation were assigned for each
Background: Postoperative pain clinical management in neonates has always been a challenging medical issue. Worldwide, several systemic opioid regimens are available for pediatricians, neonatologists, and general practitioners to control pain in neonates undergoing surgical procedures. However, the most effective and safe regimen is still unknown in the current body of literature. Objectives: To d
HIV-2 is less pathogenic compared to HIV-1. Still, disease progression may develop in aviremic HIV-2 infection, but the driving forces and mechanisms behind such development are unclear. Here, we aimed to reveal the immunophenotypic pattern associated with CD8 T-cell pathology in HIV-2 infection, in relation to viremia and markers of disease progression. The relationships between pathological diff
The derivation of dopamine neurons from human embryonic stem cells (hESCs) now offers a promising alternative to fetal tissue for cell replacement therapy (CRT) in Parkinson´s disease (PD). Using the appropriate chemical cues in vitro, hESCs can be patterned towards bona-fide ventral midbrain (VM) DA neurons that survive, reinnervate, release DA and provide functional recovery when transplanted in
In order to better understand the relations between different risk factors in the predisposition to type 2 diabetes, we present a Bayesian Network analysis of a large dataset, composed of three European population studies. Our results show, together with a key role of metabolic syndrome and of glucose after 2 hours of an Oral Glucose Tolerance Test, the importance of education, measured as the num
HT 2008 HT 2008, SOL, Linguistics The Origins of Language, 7,5 credits Course description The course aims at acquainting the student with current interdisciplinary research on the origins of language. Such research is central for the ongoing debate on the nature of language, and specifically on whether grammar is primarily a biological adaptation or a culturally created and acquired phenomenon. To
https://www.sol.lu.se/media/utbildning/dokument/kurser/LIND04/20082/OriginsHT2008-courseplan-1.doc - 2026-07-21
Svenska, språklig inriktning 1–40 poäng Autumn semester 2026 Literature list for LINK23, Phonetics: Level 3 - B. A. Course (Fonetik: Kandidatkurs), 30 credits Approved by the board of Section 1 at the Centre for Languages and Literature, 9 June 2021. Part 1: Theories of Production and Perception, 7,5 credits Esling, J.H., Moisik, S.R., Benner, A. and L. Crevier-Buchman (2019). Voice Quality. The L
https://www.sol.lu.se/media/utbildning/dokument/kurser/LINK23/20262/LINK23_KLAR.pdf - 2026-07-20
LTH-nytt 1_04 Energi för framtiden? LTH-nytt mars 2004 3LT H - n y t t • m a r s 2 0 0 4 3LT H - n y t t • m a r s 2 0 0 4 Datatjejer i Lund Designstudenter tävlade Här studeras risker och sårbarhet Nya doktorer på LTH Årets heders- doktorer 4U2choose – för yrkeselever till högskolan Årskrönika LTH 2003 Han blev första doktorn på LTH 31 28 26 25 24 22 21 LTH-nytt utges av Lunds tekniska högskola,
https://www.lth.se/fileadmin/lth/omlth/kommunikation/lthnytt/lthn04_1.pdf - 2026-07-21
Nummer 2 • 2005 LTH:S FÖRSTE REKTOR AVLIDEN • PROFESSORN TAR SIG TON • NYBYGGE FÖR NANO Konst att yvas över Konst att yvas över LT H - n y t t n u m m e r 2 • 2 0 0 52 lth-nytt och lum ska samarbe- ta mer. Från och med i höst förstär- ker universitetets personaltidning lum sin lth-bevakning. Det sker genom att undertecknad kommer att bidra mer än tidigare i lum med nyheter och reportage från lth.
https://www.lth.se/fileadmin/lth/omlth/kommunikation/lthnytt/lthn05_2.pdf - 2026-07-21
A recent meta-analysis on the political impact of the Sustainable Development Goals (SDGs) has shown that these global goals are moving political processes forward only incrementally, with much variation across countries, sectors and governance levels. Consequently, the realization of the 2030 Agenda for Sustainable Development remains uncertain. Against this backdrop, this article explores where
IMPORTANCE: In patients with clinically node-negative (cN0) breast cancer and 1 or 2 sentinel lymph node (SLN) macrometastases, omitting completion axillary lymph node dissection (CALND) is standard. High nodal burden (≥4 axillary nodal metastases) is an indication for intensified treatment in luminal breast cancer; hence, abstaining from CALND may result in undertreatment.OBJECTIVE: To develop a
Triple-negative breast cancer (TNBC) is a clinically challenging and molecularly heterogenous breast cancer subgroup. Here, we investigate the DNA methylation landscape of TNBC. By analyzing tumor methylome profiles and accounting for the genomic context of CpG methylation, we divide TNBC into two epigenetic subtypes corresponding to a Basal and a non-Basal group, in which characteristic transcrip
International development cooperation is undergoing a transformation, driven by the urgent need for more effective, holistic approaches to address enduring global challenges. This thesis explores the paradigmatic shift towards complex adaptive systems (CAS) thinking in Swedish bilateral development cooperation project management, in response to these challenges. This shift mirrors a broader evolut
An accurate molecular diagnosis of diabetes subtype confers clinical benefits; however, many individuals with monogenic diabetes remain undiagnosed. Biomarkers could help to prioritise patients for genetic investigation. We recently demonstrated that high-sensitivity C-reactive protein (hsCRP) levels are lower in UK patients with hepatocyte nuclear factor 1 alpha (HNF1A)-MODY than in other diabete
