Filtyp
OBJECTIVE: To identify all new cases of systemic lupus erythematosus (SLE) within a defined area in Southern Sweden with validated methods of retrieval, and to compare 2 cohorts assembled during 1981-86 and 1987-91. METHODS: The catchment area, the health care district of Lund-Orup, had during 1981-91 a mean adult population (> 15 years of age) of 172,300 individuals. During 1987-91 we identified
Background Dietary fibre is thought to protect against colorectal cancer but this view has been challenged by recent prospective and intervention studies that showed no protective effect. Methods We prospectively examined the association between dietary fibre intake and incidence of colorectal cancer in 519 978 individuals aged 25-70 years taking part in the EPIC study, recruited from ten European
Diffusion of medical technology and the growing proportion of elderly people in the population are generally regarded as major contributors to the increasing health care expenditure in the industrialised world. This study explores the importance of one specific factor in this process, the change in the use of technology among elderly patients. In some instances, a new technology is first used amon
The feasibility of willow short rotation coppice (SRC) for energy production as a revaluation tool for severely radiocaesium-contaminated land was studied. The effects of crop age, clone and soil type on the radiocaesium. levels in the wood were assessed following sampling in 14 existing willow SRC fields, planted on radiocaesium-contaminated land in Sweden following Chernobyl deposition. There wa
Angiogenesis is a target in the treatment of ovarian cancer. Nintedanib, an oral triple angiokinase inhibitor of VEGF receptor, platelet-derived growth factor receptor, and fibroblast growth factor receptor, has shown activity in phase 2 trials in this setting. We investigated the combination of nintedanib with standard carboplatin and paclitaxel chemotherapy in patients with newly diagnosed advan
Public spaces are the renditions of the power symmetry within the social setting it resides in, and is both controlling and confining of power. In an ideologically-laden context, urban design encompasses values and meanings and is utilized as a means to construct the identity and perpetuate visible and invisible boundaries. Hence, gendered spatial dichotomy based on a biological division of sexes
Background: The pathophysiology of neurodegeneration is complex. Its diagnosis requires an early identification of sequential changes in several hallmarks in the brains of affected subjects. The presence of brain pathology can be visualized in the cerebrospinal fluid (CSF) by protein profiling. It is clear that the field of Alzheimer’s disease (AD) will benefit from an integration of algorithms in
Context. From a light curve acquired through the K2 space mission, the star K2-111(EPIC 210894022) has been identified as possibly orbited by a transiting planet.Aims: Our aim is to confirm the planetary nature of the object and derive its fundamental parameters.Methods: We analyse the light curve variations during the planetary transit using packages developed specifically for exoplanetary transi
Biogas or methane production through anaerobic digestion (AD) is gaining increasing attention worldwide due to concerns over global warming, energy security and the need for sustainable waste management. AD of lignocellulosic biomass is one facet that is highly appreciated since the conflict over biomass for food/feed or energy can be avoided. As a result the need for non-food based lignocellulosi
Objective: To investigate the possible disease-association and pathogenic mechanisms of heterozygous PINK1 mutations from a genetic, functional, and structural perspective. Background: It has been postulated that heterozygous mutations in recessive PD genes may increase disease risk. In particular, the PINK1 p.G411S mutation has been reported in families with dominant inheritance patterns, suggest
Politicians and stakeholders widely support the “mother tongue plus two” language policy (European Commission) according to which all European citizens should be able to communicate in at least two foreign languages (FLs). However, despite high political and societal ambitions, recent reports suggest that FLs other than English are suffering in Europe and Sweden is no exception to this trend. One
Immunization is highly effective in preventing infectious diseases and therefore an indispensable public health measure. Allergic patients deserve access to the same publicly recommended immunizations as non-allergic patients unless risks associated with vaccination outweigh the gains. Whereas the number of reported possible allergic reactions to vaccines is high, confirmed vaccine-triggered aller
Forskningen i denna avhandling handlar i hög grad om att försöka härma kemin i jordens atmosfär. Den sista mätningen till denna avhandling gjordes för bara några veckor sedan, under ett fruktmellanmål tillsammans med mina barn. Jag bestämde mig för att testa ett otroligt påstående som säger att om jorden krymptes ihop till ett äpple är atmosfären lika tunn som äpplets skal. D.v.s.:tjocklek(äppleskApart from gases, the air we breath consist of tiny, so called, aerosol particles. A cubic metre of air in a relatively clean environment can consist of several billion aerosol particles. The impact of these particles on human health and on climate is significant. According to WHO, particles affect more humans than any other pollutant, and is closely related to mortality and morbidity. Further, it
Mesenchymal stromal (stem) cells (MSCs) are increasingly demonstrated to ameliorate experimentally-induced lung injuries through disease-specific anti-inflammatory actions, thus suggesting that different in vivo inflammatory environments can influence MSC actions. To determine the effects of different representative inflammatory lung conditions, human bone marrow-derived MSCs (hMSCs) were exposed
Background: Increased inflammation is reported in Major Depressive Disorder (MDD), which may be more pronounced in suicidal subjects. Vitamin D deficiency may drive this pro-inflammatory state due to vitamin D's anti-inflammatory effects. Methods: We quantified plasma 25-hydroxyvitamin D (25(OH)D) and inflammatory markers interleukin (IL)-6 and tumor necrosis factor (TNF)-α, and other inflammatory
The purpose of this dissertation is to contribute to a better understanding of the relations between music technology and girls and transgender persons (aged 13–21) in music making. The research subject is leisure time music making in music technology learning environments, where issues of gender equality are emphasized. A further aim is to discuss the music technology learning environment from th
Purpose: The study seeks to shed light on the generative principles of enterprising by examining the practices of enterprisers in six lifestyle enterprises in Sweden. It presents a fresh approach to the study of lifestyle enterprises, resolving a nuanced treatment of the concepts of capital and habitus as often drawn upon in studies using the social theory of Pierre Bourdieu. Design/methodology/ap
Water security offers to the local population an adequate quality and quantity of water for health, economy, livelihoods and ecosystems. Hence, achieving basic levels of water security should be a priority in areas where access to fresh water is scarce. The Punata alluvial fan (Bolivia) is a semiarid zone and an important agricultural zone, where the main source of water is groundwater. Therefore,
The European pulp and paper industry (PPI) directly emits 31.9 Mton CO2 (2016) and indirectly 12.3 and 5 Mton CO2 from purchased electricity and transport respectively. It also accounts for 68 Mton of biogenic CO2 emissions. The PPI is a mature industry with overall stagnating market demand in the past ten years and relatively high levels of recycling. Forest countries like Sweden and Finland domi
The overall aim of this thesis was to investigate formal care and services at home, regarding structure, process, and outcomes, for persons with dementia (aged 65+ years) at risk of nursing home admission. Availability and utilization of formal care and services at home for persons with dementia, from diagnosis to end-of-life stage, in eight European countries was described in study I. A mapping f
