Filtyp
Neuroinflammation emerges as a central driver of neurodegeneration, yet the molecular regulators orchestrating pathological microglial activation remain incompletely understood. This thesis investigates galectin-3 (Gal3), a glycan-binding protein with dual roles in microglial homeostasis and inflammatory signaling, as a master regulator linking neuroinflammation to proteinopathy progression in Alz
Denna avhandling undersöker den samtida nedmonteringen av civilsamhället i Indien genom begreppet civic governmentality. Avhandlingen hävdar att krisen för det civilas handlingsutrymme inte enbart är en berättelse om förtryck, utan om hur förutsättningarna för det civila på ett genomgripande sätt förändrats och nu präglas av auktoritär nyliberal styrning. I kontrast till dominerande narrativ som fThis thesis interrogates the contemporary unmaking of civil society in India through the analytic of civic governmentality, arguing that the crisis of civic space is not merely a story of repression but of the deeper remaking of civic subjectivity under conditions of authoritarian neoliberal rule. Against narratives that cast international non-governmental organisations (INGOs) as either heroic re
This work investigates the multi-scale dynamics of the combustion system in a lean-burn spark ignition natural gas engine using different gas injection timings (GIT). The in-cylinder pressure time series are measured, and the indicated mean effective pressure (IMEP) time series are calculated. The influence of GIT on the combustion system is investigated through wavelet analysis, multi-resolution
Denna avhandling studerar lokala aktörers roll vid förändringsarbete i gamla industriregioner. En gammal industriregion definieras som ett område med en ensidig och överspecialiserad industristruktur, som är dominerad av mogen industri och som upplever minskad sysselsättning och/eller avindustrialisering. Denna typ av region är ofta starkt påverkad av gamla strukturer och förväntas därför ha svåraThe aim of the dissertation is to develop a better understanding of the role of local agency in the transformation of old industrial regions. Theoretically the dissertation builds on concepts which are important in the debate on regional development in old industrial regions such as path dependency, negative lock-ins, the role of institutions, and new path development, while exploring and unpackin
In order to increase the competitiveness of timber as a building material in outdoor applications, durability and dimensional stability must be ensured. Acetylation enables an environmentally friendly way to increase both durability and dimensional stability of wood, without introducing harmful substances to the environment. The focus of the present research is to examine the possibility of adding
This work presents the development of a two-moment cloud microphysics scheme within version 5 of the NASA Goddard Earth Observing System (GEOS-5). The scheme includes the implementation of a comprehensive stratiform microphysics module, a new cloud coverage scheme that allows ice supersaturation, and a new microphysics module embedded within the moist convection parameterization of GEOS-5. Compreh
Precis efter Big Bang fanns endast tre grundämnen: väte, helium och en liten mängd litium. De första stjärnorna föddes i gasmoln som innehöll dessa ämnen. När den första generationen stjärnor i slutet av sina liv exploderade som supernovor spreds de tyngre grundämnena som tillverkats ut i det interstellära mediet. Nästa generations stjärnor bildades från detta berikade medium, och innehöll därför Atomic data such as oscillator strengths and wavelengths are important for astrophysical applications as they have a crucial role in determining abundances of specific elements in a star, a galaxy, or any object emitting radiation in the space. Stars in the Galaxy mostly keep the composition of the interstellar gas from which they were formed, therefore studying stellar abundances helps us underst
A detailed study of multiparticle azimuthal correlations is presented using pp data at s=5.02 and 13 TeV, and p+Pb data at sNN=5.02 TeV, recorded with the ATLAS detector at the CERN Large Hadron Collider. The azimuthal correlations are probed using four-particle cumulants cn{4} and flow coefficients vn{4}=(-cn{4})1/4 for n=2 and 3, with the goal of extracting long-range multiparticle azimuthal cor
In the era of the Internet of Things and social media; communities, governments, and corporations are increasingly eager to exploit new technological innovations in order to track and keep up to date with important new events. Examples of such events include the news, health related incidents, and other major occurrences such as earthquakes and landslides. This area of research commonly referred t
Purpose: Today’s chemical society use and emit an enormous number of different, potentially ecotoxic, chemicals to the environment. The vast majority of substances do not have characterisation factors describing their ecotoxicity potential. A first stage, high throughput, screening tool is needed for prioritisation of which substances need further measures. Methods: USEtox characterisation factors
Avhandlingen undersöker föreningar i Sverige som organiserar öppna verkstäder. Öppna verkstäder, vilka också kallas för makerspaces, är platser som möjliggör skapande. Verktyg, maskiner och kunskap är delade mellan användarna. Syftet med avhandlingen är att undersöka hur föreningar organiserar sina delade verkstäder, vilka svårigheter föreningarna möter samt vilka implikationer detta har för den bAlternative building as an interstitial mode of transformation plays a central role in the discussion of strategies for degrowth. In this debate the questions of how alternative projects can be scaled up and how degrowth politics can gain broad societal support have been identified as crucial. In this context open workshops – grassroots infrastructures for creative activities, such as repair, upcy
Spray drying, a process which is widely used in the food industry, involves the atomizations of a liquid slurry into a drying chamber to produce a powder of desired properties. Although liquid viscosity strongly influences process efficiency, few studies have examined its effect on spray characteristics for specific system designs, where previous work has been hindered by experimental/numerical ch
Key message: A candidate gene exhibiting pleiotropic effect on twelve different seed size and weight traits was identified through a combination of evidence from population genetic selection, GWAS, earlier QTL studies, transcriptome analysis, and transgenic analyses. Abstract: Peanut is an important oilseed crop. Seed weight and size significantly impact yield, leading to the identification of num
Background and objective Breathlessness is associated with higher rates of unplanned health service utilisation. We aimed to evaluate any associations between the severity of breathlessness limiting exertion (hereafter breathlessness), time between breathlessness recording and subsequent unplanned hospital admissions, and length of stay. Methods A retrospective cohort study of adults seen in gener
IntroductionThe DESOLINATION project, DEmonstration of concentrated SOLar power coupledwIth advaNced desalination system in the gulf regION, will demonstrate the efficientcoupling of a concentrated solar power (CSP) system to a membrane-based desalinationsystem at real environment. The waste heat from the CSP system will be used to drivethe membrane-based desalination processes. Therefore, the cos
Background The answer to whether females or males have better health, and which sex is the more disadvantaged, has depended in part on the metric and how the inequality is measured. This study introduces a new method for analyzing and interpreting sex inequalities in health outcomes—defined as the avoidable sex differences in health outcomes—that is systematic and potentially more objective. For t
Large skeletal muscle injuries, such as a volumetric muscle loss (VML), often result in an incomplete regeneration due to the formation of a non-contractile fibrotic scar tissue. This is, in part, due to the outbreak of an inflammatory response, which is not resolved over time, meaning that type-1 macrophages (M1, pro-inflammatory) involved in the initial stages of the process are not replaced by
Technical developments have paved the way for the development of ultrasensitive analytical methods that allow for precise quantification of brain-specific proteins in blood samples. Plasma levels of amyloid β, specifically the Aβ42/40 ratio, are reduced in Alzheimer's disease (AD) and show concordance with brain amyloidosis assessed by PET, but the overlap with normal elderly may be too large for
