Filtyp
Dispersal is of prime importance for many evolutionary processes and has been studied for decades. The reproductive consequences of dispersal have proven difficult to study, simply because it is difficult to keep track of dispersing individuals. In most previous studies evaluating the fitness effects of dispersal, immigrants at a study locality have been lumped into one category and compared to ph
Low bone mineral density (BMD) is a risk factor for fractures and much of the fracture preventive effort today is devoted to preventing low BMD. Physical activity (PA) has been described as one of the best strategies to optimize skeletal development in the growing child. However, most exercise intervention studies in children have involved the use of volunteers and specifically designed high impac
Popular Abstract in Swedish Årligen diagnostiseras cirka 60 000 nya fall av cancer i Sverige (Socialstyrelsen, 2015), och var tredje person beräknas få en cancerdiagnos under sin livstid. Trots stora framsteg inom forskning och utveckling är cancer, näst efter hjärt- och kärlsjukdomar, den vanligaste dödsorsaken i vårt samhälle. Bland de tio vanligaste formerna av cancer hör lymfom, vilket är etMantle cell lymphoma (MCL) is an aggressive form of B-cell lymphoma (BCL) with poor clinical outcome. In this thesis, which is based upon five original papers, different approaches have been used to pinpoint and investigate molecular events that promote MCL tumor growth, progression or resistance to treatment. The aim has been to identify novel targets with the potential to eradicate malignant cel
Fatigue has been shown to be a consistent and common problem in Parkinson's disease (PD) in multiple countries and cultures. It is one of the most disabling of all symptoms, including motor dysfunction, and appears early, often predating the onset of motor symptoms. Several studies of the epidemiology of fatigue have been published, often using different scales, but few on treatment. The Movement
Food quality affects growth, reproduction and community structure of zooplankton, and has implications for nutrient cycling and the transfer of energy and matter in aquatic food chains. While the issue of food quality in clear water lakes has received great recent attention, studies on food quality for zooplankton in humic lakes are scarce. Humic lakes are largely influenced by carbon of terrestri
Popular Abstract in Swedish Tumörer kan på olika sätt hämma immunsystemet och detta kan vara orsaken till varför immunterapi mot tumörer oftast inte lyckas. Denna nedreglering av immunförsvaret kan medieras av faktorer producerade från tumörcellerna själva eller så kan den följa efter en stark immunstimulering som satts igång av immunterapi. Kväve monoxid (NO) har visats vara en av de ämnen som kaDuring tumor progression a strong immunosuppression is developed and is believed to be the major reason why immunotherapy fails. This suppression is induced in response to factors produced from tumor cells, but can also be induced after immunotherapy. NO has been shown to play a major role in this suppression both in patients with gliomas and colon carcinomas. The aim of this thesis is to clarify
The plants in the ancient Roman garden were chosen with deliberation. These choices were ruled by the meaning and associations the plants conveyed to the garden visitors. Through a close reading of Latin literature and epigraphic sources (used here for the first time in relation to Roman gardens), as well as an examination of the archaeological record from Campanian garden excavations, I deal with
Mixed acid phospholipids are valuable compounds, which are used mainly in membrane- and lipoprotein research and in liposome technology. The chemical synthesis of these special lipids is rather difficult and involves both toxic chemicals and harsh reaction conditions, which makes the products less attractive for medical and biological applications. Enzymes in contrast catalyze chemical reactions u
Popular Abstract in Swedish Inom nervsystemet finns det i huvudsak två kontrollsystem: dels det somatomotoriska nervsystemet som reglerar skelettmuskulatur, dels det autonoma nervsystemet som reglerar aktivitet hos hjärta, glatt muskulatur (t.ex. blodkärl och mag-tarmkanalen) och körtlar. ?Autonom? betyder självständig och syftar till att det autonoma nervsystemet (ANS) i huvudsak inte är viljestyRespiratory sinus arrhythmia (RSA) refers to heart rate variations due to respiration, which results from parasympathetic nervous system activity mediated via the tenth cranial nerve, the vagus. Thus, the magnitude of RSA is considered as an index of cardiac vagal tone. This thesis explored RSA during emotional responding in healthy women and men. In the first two studies fear-relevant pictorial s
Human activity is constantly causing environmental problems due to production and release of numerous chemicals. A group of compounds of special concern is persistent organic pollutants (POP). These toxic, lipophilic chemicals have a high chemical and biological stability, and tend to accumulate in the lipid phase of living organisms. A major sink for POPs are sediments, and consequently these are
Wind has a profound influence on migrating birds since it inevitably will influence travel time and energy expenditure. In this thesis I investigate how migrating birds are affected by, and use winds. The studies cover the following main topics: i) the influence of wind on the decision to depart on a migratory flight, and possible energy savings by choosing to migrate in tailwinds, ii) the effect
Popular Abstract in Swedish Ett biologiskt samhälle definieras av de arter som lever och interagerar på en plats. Platsen kan vara en sjö, en ö eller ett skogsparti. Om det dessutom finns flera platser som arter sprider sig mellan brukar man tala om ett metasamhälle. Idag vet man att både ekologiska och evolutionära processer påverkar metasamhällens uppbyggnad, stabilitet och funktionalitet. DenThis thesis aims to elucidate the link between abiotic and biotic effects and biogeographical contingencies, eco-evolutionary assembly processes, and community structure in a spatially explicit metacommunity framework. To this end, we used structure analysis of naturally sampled and experimentally manipulated marine bacterial communities and mathematical eco-evolutionary modeling and simulations o
Popular Abstract in Swedish Ett beta-fosfoglukomutas i kolhydrat-metabolismen hos Lactococcus lactisPhosphoglucomutase (PGM) catalyzes the reversible conversion of glucose 1-phosphate to glucose 6-phosphate. Two distinct forms of PGM have been purifed and charactierized in Lactococcus lactis growing on maltose: one specific for the alpha-isomer, and the other specific for the beta-isomer of glucose 1-phosphate. Beta-PGM was purified and polyclonal antisera to the enzyme were generated. Beta-PGM
In this prospective study, the 10- and 15-year incidence and course of retinopathy were examined in relation to medical risk indicators from 3.1 +/- 1.9 (mean -/+ SD) years diabetes duration and onwards in 29 adult type 1 diabetic patients treated under routine care. A total of 28 patients were followed for 10 years and 20 patients for 15 years diabetes duration. After 10 years diabetes duration,
The estimated quantity of cement for construction and sealing purposes is around 9E5 kg in the planned Swedish KBS3 repository for nuclear waste. The highly alkaline cement pore fluid (pH > 12) may affect other components in the repository, and especially the bentonite buffer is of concern. In this study, we simulated possible interactions between cement and bentonite by contacting highly compacte
Introduction Human breast tumors are heterogeneous and consist of phenotypically diverse cells. Breast cancer cells with a CD44(+)/CD24(-) phenotype have been suggested to have tumor-initiating properties with stem cell-like and invasive features, although it is unclear whether their presence within a tumor has clinical implications. There is also a large heterogeneity between tumors, illustrated
BACKGROUND: Cerebral ischemia from middle cerebral artery wall (MCA) occlusion results in increased expression of cerebrovascular endothelin and angiotensin receptors and activation of the mitogen-activated protein kinase (MAPK) pathway, as well as reduced local cerebral blood flow and increased levels of pro-inflammatory mediators in the infarct region. In this study, we hypothesised that inhibit
Popular AbstractI början på 1990-talet drabbades Sverige av en mycket djup ekonomisk kris. Den svenska nittiotalskrisen uppfattades inte som en tillfällig konjunkturnedgång utan som symptom på grundläggande systemfel i Sveriges ekonomi. Många bedömare menade att den s.k. svenska modellen med stor välfärdsstat och höga skatter hade försämrat marknadsekonomins effektivitet och gjort att Sverige undeIn the early 1990s, Sweden was hit by a profound economic crisis. The Swedish crisis of the nineties was not perceived as a temporary recession, but rather as a fundamental and systemic fault in Swedish economy. Many commentators held that the Swedish model with a large welfare state and high taxes had impaired Sweden's economic performance. The aim of this thesis is to empirically assess the hypo
This report titled Best available technologies and techniques for large point sources has been prepared within the framework of the programme on Regional Air Pollution in Developing Countries (RAPIDC), Phase III conducted during the period 2005-2008. RAPIDC is funded by the Department of Infrastructure and Economic Cooperation (INEC) of the Swedish International Development Cooperation Agency SIDA
