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Discovery of a DARPin-based antitoxin against α-cobratoxin

Snakebite envenomations has for a long time been an overlooked problem, despite the hundreds of thousands of deaths and disabilities caused by this disease each year. However, since snakebite envenoming predominantly affects the rural areas of third-world countries, there was an absence of research funding and drive to address this profound concern. Consequently, costly and often highly immunogeni

Understanding contextual factors influencing insourcing decisions at a Swedish manufacturing company

Problem description: A vast amount of research has been done on outsourcing due to the trend of outsourcing activities to low-cost countries that have influenced the manufacturing industry. However, many researchers emphasize that there is not enough research conducted on the subject of insourcing decisions. Hence, it is necessary to explore this area further to create a deeper understanding of th

Detectability of fiducial markers in an MRI-only radiotherapy treatment workflow for prostate

In a conventional prostate cancer radiotherapy treatment workflow, computed tomography (CT) and magnetic resonance imaging (MRI) are used for radiotherapy treatment planning and target delineation. MRI is necessary in the process due to better soft tissue contrast compared to CT-images. Using two different imaging modalities in radiotherapy treatment planning requires image registration, which cou

Demand forecasting using Artificial Neural Network and demand pattern recognition at Sony Mobile Communication

Title: Demand forecasting using Artificial Neural Network and demand pattern recognition at Sony Mobile Communication Author: Christopher Duchateau Background: Machine Learning is considered as one of the most important technologies in this era for the society and a possible fundamental driver of economic growth. Furthermore, machine learning technology is characterized to shape a new period in

Glacial geology and palaeo-ice dynamics of two ice-sheet margins, Taymyr Peninsula, Siberia and Jameson Land, East Greenland

Popular Abstract in Swedish Arktis utgör en viktig del i Jordens miljö och vad som händer där har stor påverkan på det globala klimatet, samtidigt som området är mycket känsligt för förändringar. Under kvartärtiden har stora isar flera gånger täckt Skandinavien, Ryssland, Sibirien och Nordamerika och täcker än idag stora delar av Grönland. Isarna har lämnat spår (landformer och sediment) efter sigThe North Taymyr ice-marginal zone (NTZ) on the Taymyr Peninsula, Arctic Siberia and the Ugleelv Valley on Jameson Land, East Greenland, have been investigated with the aim of reconstructing the glacial history, including depositional processes and environments. Geomorphological, sedimentological, stratigraphical and remote sensing methods have been combined to give a comprehensive view of develop

The G-protein coupled receptor CMKLR1/ChemR23: Studies on gene regulation, receptor ligand activation, and HIV/SIV co-receptor function

Popular Abstract in Swedish För att en organism ska fungera är det nödvändigt att alla de celler som bygger upp organismen kommunicerar med varandra. Denna kommunikation sker genom att speciella proteiner på cellens yta, s.k. receptorer, tar emot signaler från andra celler. G-proteinkopplade receptorer (GPCR) är den vanligaste typen av receptorer. Då en signalmolekyl binder till en GPCR ändrar deIn all higher organisms, there is a need for intercellular communication. G-protein coupled receptors (GPCRs), located on the cell surface, play an important role in this communication. Cells synthesize and release signalling molecules (ligands), which produce a specific response only in those cells that have a receptor for that ligand. The total number of GPCRs is estimated to be around 800 where

Från guidad visning till shopping och förströdd tillägnelse: moderniserade villkor för ungdomars musikaliska lärande.

Popular Abstract in Swedish Under 1990-talet har från olika håll ställts krav på ett ökat elevinflytande över innehåll och arbetsformer i den allmänna skolan. Dessa krav har dels kommit från eleverna själva, dels kommit till uttryck i olika styrdokument. Att så har varit fallet ter sig ganska naturligt, eftersom den tidsanda i vilken vi lever är präglad av individualism. Ett antagande, som stöds aAbstract In the Swedish compulsory school system there is a trend towards increased student influence. School ideologists have for at least ten years strongly emphasised this issue. This tendency is in line with a more general direction in Western societies, which in many aspects has moved toward individualisation. Based on these developments, the main reason for undertaking the presents study was

Prosodic Phrasing in Spontaneous Swedish

Popular Abstract in Swedish Den här studien behandlar prosodisk frasering. Det talade språket fraseras på ett sådant sätt att ord som hör nära samman innehållsmässigt och/eller syntaktiskt också produceras tillsammans i en grupp. Mellan ordgrupperna – de s k prosodiska fraserna – hör vi gränser. De prosodiska frasgränserna kan således sägas vara det talade språkets punkter och kommatecken. De spel

Cell cycle deregulation in breast cancer subgroups and effects on proliferation, migration and tamoxifen resistance

Popular Abstract in Swedish Bröstcancer är den vanligaste cancerdiagnosen hos kvinnor, och under år 2011 fick över 8000 svenska kvinnor denna diagnos. Termen bröstcancer är egentligen ett samlingsnamn för alla de olika typer av cancer som kan uppstå i bröstet. En del typer av bröstcancer har en bra prognos medan andra trots aggressiv behandling alltjämt har en dålig prognos. Cancer är en sjukdom dBreast cancer is a heterogenous disease which can be divided in subgroups of distinct biology with disparate prognosis and response to treatment. The overall aim of this thesis was to delineate subgroup specific behaviour in breast cancer cells with focus on proliferation, migration and stem-like cell activity. In addition, we have studied the functional retinoblastoma tumour suppressor (RB) prote

Medical Patent Protection Impacts on Access to Medicine in China

Along with the interrelation between medical patent right, the generics impacts and the right to access to medicines, which as one of intersection issues between Intellectual Property Rights (IPRs) and Human Rights (HR), has drawn more and more attention under the international society, the Doha Declaration on TRIPS and Public Health has reaffirmed the flexibilities of the Agreement on the Trade R

Avtalsmodellerna i avtalslagen, CISG och förslaget till en gemensam europeisk köplag (CESL) - En utveckling mot en klarare avtalsmekanism?

Efter att Sverige återkallade sin reservation mot del II i FN-konventionen om internationella köp av varor (CISG) har det i svensk rätt presenterats parallella regler om avtalsslut, vid sidan av de som stadgas i den svenska avtalslagen. Inom EU har det framlagts ett förordningsförslag till en gemensam europeisk köplag (CESL). Förslaget innehåller avtals- och köprättsliga regler, inklusive regler oSweden has withdrawn its reservation against Part II of the UN Convention on Contracts for the International Sale of Goods (CISG). Thus, parallel rules on contract formation have come into force, beside those provided in the Swedish Contracts Act (Contracts Act). At EU level a Proposal for a Regulation on a Common European Sales Law (CESL) has been introduced. This paper illustrates the difference

Multipack - a growing packaging concept. An analysis of the market, the distributions/handling & cost

Since the markets of multipacks are growing we have examined the multipacks out of the perspective of opinions, handling / distribution times and costs, and cost of producing multipack both in Sweden and the UK. Our aim has been to develop a research model that can be used for future studies of other multitask markets. The research started with a thorough field study of the Swedish and UK markets

En omöjlig Gud? : en jämförelse mellan gudsbilden i postmodern teologi och östkyrklig apofatisk teologi

In some postmodern philosophy and theology, the view of God has returned to the centre of the discussion. God is seen as a living reality beyond human conception. Some of the contemporary philosophers even relate to the negative or apofatic theology. They often do this as a contrast to the positive theology. The view of God in postmodern theology and philosophy is beyond our rational knowledge. Th

Legal boundaries of the UN Security Council: Limitations in the use of targeted sanctions

The UN Security Council has been questioned ever since the time of its foundation in 1945. Mostly the criticism has evolved around its powerful status in relation to its limited number of seats and the privileges of the permanent members, such as their right to veto, thus, the question is not new. Nonetheless, the change of political circumstances in the 1990s that suddenly enabled the Council to

Comparison of EC and Vietnamese Competition Laws: Anti-competitive Agreements

The EC Competition Law has always played an important part in Community Law. Paul Craig and Gráinne de Búrca, EU Law Text, Cases, and Materials, 3rd edition 2003, page 936 This law, with its two fundamental provisions known as Articles 81 and 82 governing anti-competitive behaviours, has made great contribution to the achievement of one of the objectives laid down in the EC Treaty: ensuring that &

Mobile Virtual Network Operatotors in Europe. Strategic and Legal analysis.

Nowadays more and more mobile virtual network operators (MVNOs) are entering European market and they are considered to be mostly a European phenomenon. This is the best opportunity for telecommunication companies to expand without investments in network constructing and buying expensive licenses and also an opportunity for brand non-telco companies to enter telecommunication market. This research

Long-term Morbidity and Socioeconomic Outcome among Nordic Childhood Cancer Survivors

Survival after childhood cancer has improved dramatically during the past four decades, resulting in a five-year survival rate of 80% in children recently treated for cancer in the Nordic countries. However, these advances in treatment and survival has come at a price, and many survivors face significant treatment-induced sequelae, most of which only become clinically apparent many years after the

The Many Facets of bicoid Gradient Formation in Drosophila

In Drosophila, the Bicoid protein servers as paradigm as the first identified morphogen, whose concentration gradient provides the initial positional information in the anterior half of the embryo. There, it differentially activates segmentation genes, in particular the gap genes. Insofar, there are two mainly prevailing models to explain how the Bicoid protein concentration gradient forms: 1) the

Current taxonomy of the lichen family Teloschistaceae from India with descriptions of new species

The present study recorded 36 genera and 115 species of the lichen family Teloschistaceae in India. Three species, i.e. Caloplaca rajasthanica S. Y. Kondr., Upreti et G. P. Sinha, Huriella upretiana S. Y. Kondr., G. K. Mishra, Nayaka et A. Thell, and Squamulea uttarkashiana S. Y. Kondr., Upreti, Nayaka et A. Thell, are described as new species. Seven new combinations, i.e. Fulgogasparrea awasthii

Analysis of antibody markers, DRB1, DRB5, DQA1 and DQB1 genes and modeling of DR2 molecules in DR2‐positive patients with insulin‐dependent diabetes mellitus

Abstract: HLA‐DR2 is negatively associated with insulin‐dependent diabetes mellitus (IDDM). The aim of the present study was to analyze DR2‐positive patients among 425 consecutively diagnosed unrelated Swedish children with IDDM and in 367 matched controls. HLA‐DRB, ‐DQA and ‐DQB were determined by Taq I restriction fragment length polymorphism analysis. Amplification by polymerase chain reaction