Filtyp
OBJECTIVE: Chronic obstructive pulmonary disease (COPD) and coronary artery disease (CAD) are leading causes of global morbidity and mortality. There is a well-known comorbidity between COPD and CAD, which is only partly explained by smoking and other known common risk factors. In order to better understand the relationship between COPD and CAD, we analyzed myocardial perfusion, pulmonary function
Since the Industrial Revolution, human activities have elevated atmospheric CO2 concentrations. The consequences of this include rising temperatures, shifts in precipitation patterns, and increased intensity and frequency of extreme weather events, such as heat waves and droughts. Elevated temperatures can accelerate microbial activity in soil, potentially resulting in an increased rate of soil or
Background & aim: Clinical trials supplementing the long-chain polyunsaturated fatty acids (LCPUFAs) docosahexaenoic acid (DHA) and arachidonic acid (AA) to preterm infants have shown positive effects on inflammation-related morbidities, but the molecular mechanisms underlying these effects are not fully elucidated. This study aimed to determine associations between DHA, AA, and inflammation-r
The use of digital technologies to deliver primary health care has increased over the past decade. While some technologies have been shown to be medically effective and efficient, the effects of digital primary care on the policy goal of equality in the use of such types of care have not been studied using large register data. The aim of this study was to analyse how digital contacts differ from o
BackgroundChemoreception is crucial for insect fitness, underlying for instance food-, host-, and mate finding. Chemicals in the environment are detected by receptors from three divergent gene families: odorant receptors (ORs), gustatory receptors (GRs), and ionotropic receptors (IRs). However, how the chemoreceptor gene families evolve in parallel with ecological specializations remains poorly un
The incretin hormones, glucose dependent insulinotropic polypeptide (GIP) and glucagon-like peptide 1 (GLP-1), potentiate insulin secretion and are responsible for the majority of insulin secretion that occurs after a meal. They may also, however, have a fundamental role in pancreatic beta cell development and function, independently of their role in potentiating insulin secretion after a meal. Th
The codification of canon law in the twelfth and thirteenth centuries occurred at the same time as important changes in pastoral practice. This article deals with changes in the practice of baptism that are tied to changes in canonical regulations.Canon law makes a fundamental distinction between solemn baptism and emergency baptism. While emergency baptisms could take place anywhere and at any ti
The subject matter of the thesis is the comprehensive - legal and multidisciplinary - analysis of the terms 'peoples' and 'minorities' in international law. The argument of the author proceeds in four parts: the Problematique which deals with the 'minority challenge' and the international normative response to that challenge; the Critique, criticizing the basic underlying assumptions of the discou
Background: Impaired gait can precede dementia. The associations between gait parameters and brain pathologies are therefore of interest. Objective: To explore how different brain pathologies (i.e., vascular and Alzheimer's) are associated with specific gait parameters from various gait components in persons with mild cognitive impairment (MCI), who have an increased risk of developing dementia. M
Purpose: With modern treatments, mantle cell lymphoma (MCL) patients more frequently experience long-lasting remission resulting in a growing population of long-term survivors. Follow-up care includes identification and management of treatment-related late-effects, such as secondary malignancies (SM). We conducted a population-based study to describe the burden of SM in MCL patients. Methods: All
Objectives A rising incidence of septic shock as well as recommendations for early vasopressor initiation has increased the number of patients eligible for norepinephrine (NE). Traditionally, NE has been administered through central lines, in intensive care units, due to the risk of extravasation in peripheral lines. The aim of the current study is to determine the rate of complications and patien
Background and AimsAdolescent mental health has declined in recent decades. Few studies have explored whether shifts in interpersonal behaviours– both in-person and online– can help explain this decline. Using data from two Swedish cohorts (2007–2008, 2023–2024), we examined (1) 15-year time trends (2007–2008 vs. 2023–2024) in interpersonal behaviours (victimization, aggression, prosocial behaviou
BACKGROUND: The increasing longevity of people with intellectual disability creates a need for a healthy-ageing perspective, translated into evidence-based interventions in this multi-morbidity group. Accordingly, the aim of this scoping review was to identify, summarise and analyse the empirical research on healthy ageing in older adults with intellectual disability.METHODS: This review was based
OBJECTIVES: To evaluate whether suicidality was documented prior to suicide in patients in contact with specialised somatic healthcare providers for physical conditions and to identify factors related to such documentation.DESIGN AND SETTINGS: Retrospective cohort study in which medical records from specialised somatic (non-psychiatric) healthcare services (internal medicine, infectious disease, s
Popular Abstract in Swedish Färger innehåller mer tillförlitlig information än vad bara skillnader i ljusintensitet gör. Det är därför inte svårt att förstå varför de allra flesta landlevande ryggradsdjur har färgseende. Några upplever en färgfattigare värld än vi människor, men många ser fler färgnyanser. På kvällen däremot gör bristen på ljus det svårt att se färger. Trots detta finns det nattakMost terrestrial vertebrates have colour vision, some perceive a less colourful world and others actually discriminate a wider colour spectrum than humans do. Still, we can all make use of the valuable colour information, which is more rigid than just brightness. However, at night when the light is dim, the lack of photons makes colour vision difficult. Nevertheless, some hawkmoths and bees can se
Objectives: To identify factors that predict the use of community-based home help services in long-term cholinesterase inhibitor (ChEI)-treated patients with Alzheimer’s disease (AD). Methods: The Swedish Alzheimer Treatment Study (SATS) is an open, prospective, non-randomized, multicentre study in a routine clinical setting. Patients with AD living at home at the time of inclusion received treatm
Environmental loads, such as wind and river flow, play an essential role in the structural design and structural assessment of long-span bridges. Climate change and extreme climatic events are threats to the reliability and safety of the transport network. This has led to a growing demand for digital twin models to investigate the resilience of bridges under extreme climate conditions. Kalix bridg
Proteoglycans (PGs) consist of a core protein with covalently bound glycosaminoglycan (GAG) chains that are linked via a tetrasaccharide. PGs are important macromolecules that are involved in biological processes such as cell growth and differentiation. A key enzyme in the biosynthesis of PG GAG chains is β-1,4-galactosyltransferase 7 (β4GalT7) that catalyzes the transfer of galactose to a xylose
Estimated glomerular filtration rate (eGFR) reflects kidney function. Progressive eGFR-decline can lead to kidney failure, necessitating dialysis or transplantation. Hundreds of loci from genome-wide association studies (GWAS) for eGFR help explain population cross section variability. Since the contribution of these or other loci to eGFR-decline remains largely unknown, we derived GWAS for annual
