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Background Relatives of breast cancer cases have an increased risk of the disease. The risk increases with increasing numbers and decreasing age of onset of affected relatives. In families with a BRCA1 or a BRCA2 mutation, individual carrier status predicts the risk of breast cancer. In relatives of cases where both BRCA1 and BRCA2 mutations are excluded, the risk remains undetermined. Methods Sta

We search for signatures of past accretion events in the Milky Way in the recently published catalogue by Nordstrom et al., containing accurate spatial and kinematic information as well as metallicities for 13 240 nearby stars. To optimize our strategy, we use numerical simulations and characterize the properties of the debris from disrupted satellites. We find that stars with a common progenitor

The Formoterol and Corticosteroids Establishing Therapy (FACET) study has provided the first opportunity to examine the long-term effects of inhaled steroids and long-acting beta2-agonists on asthma-specific quality of life. The objectives of the present study were to: evaluate the effects of long-term (1 yr) formoterol and increasing doses of budesonide on asthma quality of life; 2) to determine

The nonobese diabetic ( NOD) Nss1 and Idd5 loci have been associated with sialadenitis development in mice. In this study the NOD Nss1 and Idd5 loci were backcrossed onto the healthy control strain B10. Q by using the speed congenic breeding strategy, resulting in three congenic strains: B10. Q. Nss1, B10. Q. Nss1/Idd5 heterozygous and B10. Q. Nss1/Idd5 homozygous. We investigated the effects of t

The rates of positive tuberculin skin test (TST) reactions and BCG scarring after BCG vaccination vary between studies and populations. Tuberculin reactivity and BCG scarring may be related to better child survival in low-income countries. We therefore studied determinants for TST reaction and scarring in Guinea-Bissau. In a cohort of children born in suburban Bissau from March 2000 to July 2002,

In spite of its immune privileged state, xenotransplantation within the CNS is associated with rapid graft destruction in immunocompetent hosts. Efforts to enhance graft survival have mostly focused on host immune response, whereas relatively little attention has been paid to donor tissue characteristics. In the present paper, we explore long-term survival of xenogeneic full-thickness neuroretinal

The transcription factor T-cell factor 7-like 2 (TCF7L2) confers type 2 diabetes risk mainly through impaired insulin secretion, perturbed incretin effect and reduced beta-cell survival. The aim of this study was to identify the molecular mechanism through which TCF7L2 influences beta-cell survival. TCF7L2 target genes in INS-1 cells were identified using Chromatin Immunoprecipitation. Validation

In Sweden, 13 % of all transport is related to business travelling, resulting in significant emissions of not only CO2, but also of NOx, VOC, CO and particle matter. The implication for business will not only come in the form of ecological impacts affecting the natural resource base; as people around the world wake up to the fact that issues, like climate change, are a real threat to their welfare

Popular Abstract in Swedish Avhandlingen består av fyra kapitel. Efter det inledande kapitlet används i kapitel två och tre ekonomiska experiment för att undersöka hur deltagare fördelar ett överskott mellan sig då det finns två fokalpunkter. Kapitel fyra undersöker huruvida en penningpolitisk störning har asymmetriska effekter på de svenska länens sysselsättning. I kapitel två, samförfattat med This thesis consists of two parts. The first part uses economic experiments to investigate how participants choose to divide a surplus in the presence of competing focal points. The second part examines whether a monetary policy shock has asymmetric regional effects. Chapter 2 suggests a simple separation mechanism based on heterogeneity among subjects to understand how they choose equilibrium wh

ABSTRACT: INTRODUCTION: The amplification event occurring at chromosome locus 11q13, reported in several different cancers, includes a number of potential oncogenes. We have previously reported amplification of one such oncogene, namely CCND1, to be correlated with an adverse effect of tamoxifen in premenopausal breast cancer patients. Over-expression of cyclin D1 protein, however, confers tamoxif

Geographic accessibility to services is important. Having a grocery store and a school nearby are important living conditions and having a rescue station close by could be a life-saver. Costs for transportation are high and are predicted to increase, new environmental demands are being imposed on transportation and rationalizations are centralizing public and commercial services. These facts make

The Network Construction problem, studied by Angluin et al., Hosoda et al., and others, asks for a minimum-cost network satisfying a set of connectivity constraints which specify subsets of the vertices in the network that have to form connected subgraphs. More formally, given a set V of vertices, construction costs for all possible edges between pairs of vertices from V, and a sequence S1,S2,…,Sr

Lunds Botaniska Förening och Eslövs kommun har genomfört ett LONA-projekt 2020–2022 inom vilket kommunens ansvarsarter humlesuga, Betonica offi- cinalis L., och kärrnäva, Geranium palustre L., har odlats och planterats på reservlokaler. Även ängs- skära, Serratula tinctoria L., och gullstånds, Jaco- baea paludosa (L.) P. Gaertn., har ingått i projektet. Antalet spontana exemplar i kommunen uppgickA LONA (local nature conservation support) project administrated by Eslöv town in cooperation with Lund Botanical Society was undertaken in 2020– 2022 to determine the status of the protected plant species Betony (Betonica officinalis L.) and Marsh Crane’s-bill (Geranium palustre L.) in natural popu- lations. The second main goal of the project was to establish the species in planted back-up local

We report the discovery and characterization of two transiting planets around the bright M1 V star LP 961-53 (TOI-776, J = 8.5 mag, M = 0.54 ± 0.03 M⊙) detected during Sector 10 observations of the Transiting Exoplanet Survey Satellite (TESS). Combining the TESS photometry with HARPS radial velocities, as well as ground-based follow-up transit observations from the MEarth and LCOGT telescopes, for

The derivation of dopamine neurons from human embryonic stem cells (hESCs) now offers a promising alternative to fetal tissue for cell replacement therapy (CRT) in Parkinson´s disease (PD). Using the appropriate chemical cues in vitro, hESCs can be patterned towards bona-fide ventral midbrain (VM) DA neurons that survive, reinnervate, release DA and provide functional recovery when transplanted in

Homeless youth are a vulnerable and understudied group who hasconsistently reported elevated levels of substance use. Understanding the factors associated with substance use within this population may help guide future intervention efforts. Although few studies have examined the role of abstinence self-efficacy and coping in substance use among homeless youth, some research indicates that higher a

Background: Data regarding the impact of preheart failure (HF) comorbidities on the prognosis of HF are scarce, especially in the younger HF patients. Objectives: To investigate pre-existing comorbidities in HF patients versus matched controls and to assess their impact on mortality. Methods: We included all first-time in-hospital and outpatient diagnoses of HF from 1995 to 2017, and comorbidities

Metamorphosis is a vital developmental event in the life cycle of molluscs and involves extensive morphological and physiological changes. Remodeling of the digestive system is suggested to occur anticipatorily to enable the larva to shift its diet (from filter feeding on microalgae to feeding on small bivalves) after metamorphosis. Changes in the profiles and activities of digestive enzymes, the

The collective fight for self-determination among indigenous peoples around the world has made headlines over the past few years. The exploitation of indigenous territories by settler-states has revived nationalist feelings among the groups, including the Sami, whose territories spread across four states. This thesis aimed to explore how Sami national identity is constructed, shaped and promoted