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BACKGROUND: Antibiotic resistance is a serious global public health problem directly correlated to high antibiotic consumption. Romania is one of the European countries with the highest rates of antibiotic consumption, non-prescription antibiotics use and resistance of several pathogens to antibiotics. Pharmacists are an important stakeholder in respect to antibiotic management and context specifi

Objective(s): Colombia has the third largest black population in the Americas after Brazil and the USA. In 2005 mortality rate under 5 in Colombia was 21.5 per 1000, with a reduction of 82 per cent between 2005 and 1960. That rate is not in line with rates for Cuba (6.8), Chile (9.1) or Costa Rica (10.4). Here we aim to provide evidence that a further reduction of child mortality relates to the un

Abstract: The recent turbulent evolution of the 3D printing industry is strictly related with two important phenomena: the widespread adoption of Open Source (OS) business models by new companies on the one hand, and the increasing importance of communities of users, such as the so-called Maker Movement, on the other. This study is the first to analyze the factors that drive the adoption of differ

Denna avhandling studerar den moraliska konfliktlinje som genomsyrade den frihetstida politiken åren kring 1740 och som strukturerade politiken enligt en särskilt moralpolitisk logik. Logiken hade sin grund i dels samhällsordningens absoluta och normativt oföränderliga karaktär, dels ett antal djupa förmoderna erfarenheter av och förväntningar på människan som oförmögen att hantera sin fördärvade This thesis examines the moral conflict permeating the politics of Sweden’s Age of Liberty around 1740 – a conflict that also structured the politics of the time in relation to a particular political logic based on moral. This logic was based on the absolute and normatively immutable nature of the social order, but also on a number of deep pre-modern experiences and expectations of man as unable t

Popular Abstract in Swedish Psykoakustik och hallucinerande schizofrena Hallucinationer för hörseln är ett stort problem vid schizofreni. Många har försökt förklara men ingen lyckats. Denna avhandling påvisar avvikelser vid schizofrenisjukdomen vilka kan utgöra grundstenar för framtida förståelse av detta plågsamma symptom. Vad är psykoakustik ? Psykoakustik kan beskrivas som psykofysiska studiePsychoacoustic experiments have been conducted for schizophrenic patients with auditory hallucinations in their case history and for reference subjects. The aim of the thesis has been to assess differences between the two groups of subjects. The experiments consisted of tests on perceptual grouping mechanisms measuring how sound with high and low pitches is separated into perceptual streams (Study

Context: Systems of systems (SoS) are highly complex and are integrated on multiple levels (unit, component, system, system of systems). Many of the characteristics of SoS (such as operational and managerial independence, integration of system into system of systems, SoS comprised of complex systems) make their development and testing challenging. Contribution: This paper provides an understanding

Remote sensing (RS) data provide large-scale observations to measure water quality parameters (WQPs) like turbidity (Turb), which indicates the haziness of the water. Accurately estimating these parameters solely from RS data is inherently complex due to various factors, necessitating the use of advanced models capable of capturing the intricate relationships between RS spectral bands as an input

Background: Biallelic variants in the major facilitator superfamily domain containing 8 gene (MFSD8) are associated with distinct clinical presentations that range from typical late-infantile neuronal ceroid lipofuscinosis type 7 (CLN7 disease) to isolated adult-onset retinal dystrophy. Classic late-infantile CLN7 disease is a severe, rare neurological disorder with an age of onset typically betwe

Hereditary ataxia is a heterogeneous group of complex neurological disorders. Next-generation sequencing methods have become a great help in clinical diagnostics, but it may remain challenging to determine if a genetic variant is the cause of the patient’s disease. We compiled a consecutive single-center series of 87 patients from 76 families with progressive ataxia of known or unknown etiology. W

The aim of this Intensive Care Medicine Rapid Practice Guideline (ICM-RPG) was to provide evidence-based clinical guidance about the use of higher versus lower oxygenation targets for adult patients in the intensive care unit (ICU). The guideline panel comprised 27 international panelists, including content experts, ICU clinicians, methodologists, and patient representatives. We adhered to the met

In this article, we present a fragment model potential approach for the description of the crystalline environment as an extension of the use of embedding ab initio model potentials (AIMPs). The biggest limitation of the embedding AIMP method is the spherical nature of its model potentials. This poses problems as soon as the method is applied to crystals containing strongly covalently bonded struc

Should boxing be banned? Do the ever-so-obvious risks outweigh everyone's freedom to choose whether to expose oneself to these risks by taking up the sport? On an official level, the RCN in the UK has taken its stand--it does not! So has also the British Medical Association (BMA)--it does! With few exceptions, the responding nurses from Europe, America, and Australia in this month's column seem to

this study we investigated the effects of gastrectomy (Gx) and of the gastric hormone, ghrelin, on the expression of proteins in brown adipose tissue (BAT) that are thought to be involved in thermogenesis. Heat production in BAT is known to depend upon activation and increased expression of β3-adrenergic receptors (β3-AR) and the consequent up-regulation of uncoupling protein 1 (UCP1). Mice were s

Chromosome abnormalities have been reported in more than 46,000 benign and malignant neoplastic disorders, leading to the identification of numerous recurrent abnormalities. A substantial number of recurrent balanced aberrations (RBAs), in particular, reciprocal translocations, occur with remarkable specificity in association with clinical and tumor characteristics. This information has become inc

Acute myeloid leukemia (AML) with inv(16)(p13q22) or the variant t(16;16)(p13;q22), is strongly associated with the FAB subtype M4Eo. A high incidence of CNS involvement was reported in the 1980s, but otherwise little is known about the pattern of extamedullary leukemia (EML) manifestations in this AML type. We have compiled clinical and cytogenetic data on 27 consecutive AML cases with inv(16)/t(

Background: Previous studies showing a strong relationship between Cheyne-Stokes respiration and the severity of left ventricular systolic dysfunction have usually been done in selected patient populations with lower age and a higher proportion of males than the "typical" in-hospital patient with heart failure. The purpose of the present study was test the strength of this relationship in unselect

Background: Matrix metalloproteinase (MMP)-mediated degradation of the extracellular matrix is a key point in tumor development and expansion. MMP-10 is one of the most important and well-characterized members of the MMP family. In the present study, we examined MMP-10 mRNA and protein levels in non-small cell lung cancer (NSCLC). Patients and Methods: Three endogenous reference genes including GA