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INTRODUCTION: Autoimmune disorders have become increasingly acknowledged as having a more causative role in encephalitis than previously assumed. Anti-N-methyl-D-aspartate receptor encephalitis seems to be the most prevalent disorder. Symptoms of the neuropsychiatric phase in children and adolescents include abnormal behavior, seizures, and neurologic symptoms. We present a report on a teenage gir
Molecular recognition is fundamental to biological signaling. A central question is how individual interactions between molecular moieties affect the thermodynamics of ligand binding to proteins and how these effects might propagate beyond the immediate neighborhood of the binding site. Here, we investigate this question by introducing minor changes in ligand structure and characterizing the effec
Background: Foot-and-mouth disease viruses (FMDVs) are members of the picornavirus family and cause an economically important disease of cloven-hoofed animals. To understand the structural basis of antigenic variation in FMDV, we have determined the structures of two viruses closely related to strain O1BFS whose structure is known. Results The two new structures are, like O1BFS, both serotype O vi
Brain tissue segmentation plays a crucial role in feature extraction, volumetric quantification, and morphometric analysis of brain scans. For the assessment of brain structure and integrity, CT is a non-invasive, cheaper, faster, and more widely available modality than MRI. However, the clinical application of CT is mostly limited to the visual assessment of brain integrity and exclusion of copat
Gambling Disorder (GD) has recently been reclassified from an impulse-control disorder to a behavioural addiction and, as in other addictive disorders, the dopaminergic reward system is involved. According to neuroimaging studies, alterations within the striatal dopaminergic signalling can occur in GD. However, the findings to date are controversial and there has been no agreement yet on how the r
Context. Energy and momentum injected by young, massive stars into the surrounding gas play an important role in regulating further star formation and in determining the galaxy's global properties. Before supernovae begin to explode, stellar feedback consists of two main processes: Radiation pressure and photoionisation. Aims. We study pre-supernova feedback and constrain the leakage of Lyman cont
Two commonly used instruments to assess muscle strength after anterior cruciate ligament reconstruction are the isokinetic dynamometer, which measures isokinetic torque and the hand-held dynamometer, which measures isometric torque. Isokinetic dynamometers are considered superior to other instruments but may not be commonly used in clinical settings. Hand-held dynamometers are small, portable, and
BackgroundFor implementation of new assessment strategies, an evidence-informed approach is desired. Thus, the assessment methodshould be supported by current evidence, and similarly the implementation process could be informed through research.Implementation research can be done using various approaches and research methods. However, it seems that interviewstudies are an important source of infor
Different processes in response to the action of natural driven forces and the human interference on coastal systems act together, contributing to shape the coast. Coastal evolution models have been developed as useful tools to better understand the contribution of different processes on observed coastal changes, and also to anticipate future evolution in response to different actions and interven
BACKGROUND: Antibiotic resistance is a serious global public health problem directly correlated to high antibiotic consumption. Romania is one of the European countries with the highest rates of antibiotic consumption, non-prescription antibiotics use and resistance of several pathogens to antibiotics. Pharmacists are an important stakeholder in respect to antibiotic management and context specifi
Objective(s): Colombia has the third largest black population in the Americas after Brazil and the USA. In 2005 mortality rate under 5 in Colombia was 21.5 per 1000, with a reduction of 82 per cent between 2005 and 1960. That rate is not in line with rates for Cuba (6.8), Chile (9.1) or Costa Rica (10.4). Here we aim to provide evidence that a further reduction of child mortality relates to the un
Abstract: The recent turbulent evolution of the 3D printing industry is strictly related with two important phenomena: the widespread adoption of Open Source (OS) business models by new companies on the one hand, and the increasing importance of communities of users, such as the so-called Maker Movement, on the other. This study is the first to analyze the factors that drive the adoption of differ
Denna avhandling studerar den moraliska konfliktlinje som genomsyrade den frihetstida politiken åren kring 1740 och som strukturerade politiken enligt en särskilt moralpolitisk logik. Logiken hade sin grund i dels samhällsordningens absoluta och normativt oföränderliga karaktär, dels ett antal djupa förmoderna erfarenheter av och förväntningar på människan som oförmögen att hantera sin fördärvade This thesis examines the moral conflict permeating the politics of Sweden’s Age of Liberty around 1740 – a conflict that also structured the politics of the time in relation to a particular political logic based on moral. This logic was based on the absolute and normatively immutable nature of the social order, but also on a number of deep pre-modern experiences and expectations of man as unable t
Popular Abstract in Swedish Vatten är inte bara en oumbärlig resurs varav allt liv är beroende. Det är också en grundläggande ekonomisk resurs för samhällsutvecklingen. Av allt vatten på jorden är bara 0,34% tillgängligt för människan. Övriga vattenresurser föreligger som saltvatten, is eller djupt liggande grundvatten. Vattenkrisen på jorden är stor och över 780 miljoner människor saknar rimlig tFresh water scarcity, pollution and an uneven distribution have caused an increasingly serious global water crisis. One of the most widely adopted response strategies is the exploitation and use of non-conventional water sources. Water reuse and desalination were in focus in the study which was aimed to develop the strategies to promote the sustainable and safe use of reclaimed water and desalinat
Popular Abstract in Swedish Psykoakustik och hallucinerande schizofrena Hallucinationer för hörseln är ett stort problem vid schizofreni. Många har försökt förklara men ingen lyckats. Denna avhandling påvisar avvikelser vid schizofrenisjukdomen vilka kan utgöra grundstenar för framtida förståelse av detta plågsamma symptom. Vad är psykoakustik ? Psykoakustik kan beskrivas som psykofysiska studiePsychoacoustic experiments have been conducted for schizophrenic patients with auditory hallucinations in their case history and for reference subjects. The aim of the thesis has been to assess differences between the two groups of subjects. The experiments consisted of tests on perceptual grouping mechanisms measuring how sound with high and low pitches is separated into perceptual streams (Study
Context: Systems of systems (SoS) are highly complex and are integrated on multiple levels (unit, component, system, system of systems). Many of the characteristics of SoS (such as operational and managerial independence, integration of system into system of systems, SoS comprised of complex systems) make their development and testing challenging. Contribution: This paper provides an understanding
Earth’s primary production depends to a considerable extent on the mycorrhizal symbiosis, since mycorrhizal fungi supply their host plant with important mineral nutrients. I examined the influence of different nutrient regimes on the fungal partner in the arbuscular mycorrhizal symbiosis. I especially focused on salinity problems, as they occur in southern Tunisia, where I performed several field
Abstract:Background Type 1 diabetes (T1D) is one of the most common childhood autoimmune diseases, with rising incidence worldwide with a male predominance. The etiology behind the disease is mostly unknown and it is essential to understand the factors that impact its development to prevent the disease and personalize the treatment. This thesis aims to examine sex-specific differences in T1D, expl
Remote sensing (RS) data provide large-scale observations to measure water quality parameters (WQPs) like turbidity (Turb), which indicates the haziness of the water. Accurately estimating these parameters solely from RS data is inherently complex due to various factors, necessitating the use of advanced models capable of capturing the intricate relationships between RS spectral bands as an input
