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In animal models of Parkinson's disease, striatal overactivation of ERK1/2 via dopamine (DA) D1 receptors is the hallmark of a supersensitive molecular response associated with dyskinetic behaviors. Here we investigate the pathways involved in D1 receptor-dependent ERK1/2 activation using acute striatal slices from rodents with unilateral 6-hydroxydopamine (6-OHDA) lesions. Application of the dopa

A review of literature related to fire evacuation in underground transportation systems, e.g., tunnels and subway stations, was carried out with the objectives (1) to identify a theoretical framework that can help understand of human behaviour in the event of a fire in underground transportation systems, (2) to use the theoretical framework to analyse and to identify problems related to fire evacu

A Course in Miracles (ACIM) is a spiritual teaching that was said to be channelled by Helen Shucman during 1965-1972. Shucman received what she described as an inner dictation, which she wrote down in shorthand. Her collegue and friend; William Thetford was then copy-typing the text. It came to comprise of around 1,200 pages of text, and is presented as a program of self-tuition, aimed to change a

In order to describe the influence of Pleistocene glaciations on the genetic structure and demography of a highly mobile, but specialized, passerine, the Savi’s Warbler (Locustella luscinioides), mitochondrial DNA sequences (ND2) and microsatellites were analysed in c.330 individuals of 17 breeding and two wintering populations. Phylogenetic, population genetics and coalescent methods were used to

Angular correlations between unidentified charged trigger (t) and associated (a) particles are measured by the ALICE experiment in Pb-Pb collisions at root s(NN) = 2.76 TeV for transverse momenta 0.25 < p(T)(t,a) < 15 GeV/c, where p(T)(t) > p(T)(a). The shapes of the pair correlation distributions are studied in a variety of collision centrality classes between 0 and 50% of the total hadronic cros

Intensive agricultural practices can dramatically change the landscape, thereby increasing the concentrations and rates at which nutrients are delivered to aquatic ecosystems. In the United States, concerns about accelerating rates of lake eutrophication related to increases in nutrient loading require a method of quantifying ecological changes that have occurred since European settlement. Because

The Canons of Dalby. Three Studies I. When did the brothers in Dalby become Augustinians? There are different opinions among historians about what kind of community Egino founded in Dalby in the late 1060s. Some say it was Benedictine, others say it was a community of canons. Among the latter, some say they were regular canons, others that they were secular, and one distinguished historian has ev

The loss of native riparian vegetation and its replacement with non-native species or grazing land for agriculture is a worldwide phenomenon, but one that is prevalent in Europe, reflecting the heavily-modified nature of the continent's landscape. The consequences of these riparian alterations for freshwater ecosystems remain largely unknown, largely because bioassessment has traditionally focused

Pain upon negative pressure wound therapy (NPWT) dressing removal has been reported and is believed to be associ- ated with the observation that granulation tissue grows into foam. Wound tissue damage upon removal of the foam may cause the reported pain. Calcitonin gene-related peptide (CGRP) and substance P are neuropeptides that cause inflam- mation and signal pain and are known to be released w

This study analyses the effects of thinning on stand transpiration in a typical mixed spruce and pine forest in the southern boreal zone. Studies of transpiration are important for models of water, energy and carbon exchange, and forest management, like thinning, would change those processes. Tree transpiration was measured by the tissue heat-balance sapflow technique, on a reference plot and a th

One of the most dynamic interactions between humans and technology of our time is the development of artificial intelligence, materialized in various types of communicative robots. Thrilling questions are raised about how human-like these robots can be and how far this interaction will go. It is no exaggeration to state that speculations about the robots’ role in our lives far exceed what we know

Popular Abstract in Swedish Populärvetenskaplig sammanfattning Öroninflammtionen är en av våra vanligaste åkommor, och den drabbar framför allt små barn. Av alla bakteriella infektioner är det den som oftast för oss till läkare. Vanligen resulterar läkarbesöket i en kur med bakteriedödande läkemedel som penicillin. P.g.a den idag höga konsumtionen av penicillin och liknande medel, är risken påtag

Inscriptions, i.e. the result of how users write, draw, sketch, model or paint or otherwise create persistent content are an important object of study in interaction design. It is conceptualized in many different ways – as representation, externalization, reification, notation, articulation, to name a few, and the resulting conceptual plethora creates problems for advancing scientific understandin

Popular Abstract in Swedish Sverige har den näst högsta frekvensen av nyinsjuknade typ 1 diabetespatienter i världen, ungefär 20-25 av 100.000 personer utvecklar sjukdomen varje år, både bland personer i åldern 0-15 år och bland de som är 15-34 år. Insulin är den nyckel som öppnar upp cellerna så att sockermolekylen kan komma in i cellen och fungera som bränsle. Insulin bildas i de Langerhanska öaThis thesis presents the results from a study of the first four years of diabetes in 879 patients aged 15-34 years at diagnosis. The aims of this study were to compare clinical classification with the presence of autoantibodies, to study the natural course of beta cell function during the first years of disease and to define predictive factors for the remaining beta cell function after diagnosis.

Interactions between land surface and atmosphere induced by human activities and natural environmental dynamics act on a time scale that varies from seconds to millions of years. It is by exchanging heat, water, energy and carbon that land surface and atmospheric processes are closely interrelated and influence each other in reciprocal ways. Among the natural interactions between land surface and

BACKGROUND Relatively few studies published to date have investigated IVF and cancer risk. In this study we compared the occurrence of cancer in women who gave birth after IVF with all other women who gave birth in the study period. METHODS All women who were treated with IVF and gave birth during the years 1982-2006 in Sweden were identified from all IVF clinics, and the occurrence of cancer in t

Background The aim of this study was to investigate the prevalence of cerebral palsy (CP) as well as to characterize the CP population, its participation in a secondary prevention programme (CPUP) and to validate the CPUP database. Methods The study population was born 1990–1997 and resident in Skåne/Blekinge on Jan 1st 2002. Multiple sources were used. Irrespective of earlier diagnoses, neuropa

Popular Abstract in Swedish Skadeståndsrätten innehåller alternativa definitioner på culpa. Den innehåller tre Konkurrerande culpakriterier. Enligt normalitetskriteriet föreligger culpa om den som orsakat en skada inte har vidtagit de försiktighetsåtgärder som en normalt aktsam person hade vidtagit i motsvarande situation. Enligt det ekonomiska kriteriet föreligger culpa om skadan hade kunnat förhThe concept of negligence in tort law can be defined in (at least) three different ways. Negligence can be defined in terms of normality, i.e. as failing to act in accordance with custom or failing to meet the level of care taken by normally careful citizens. It can be defined in terms of efficiency. In that case it would mean refraining from taking a precaution that costs less to take than it sav