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Våra röda blodkroppar lever i genomsnitt 120 dagar och bryts därefter ner avmakrofagerna, immunsystemets medfödda städare av både främmande och egnaceller. De röda blodkropparnas uppgift är att transportera syre från lungorna tillkroppens olika vävnader och föra tillbaka koldioxid. Men vad händer om de rödablodkropparna bryts ner ovanligt snabbt eller helt enkelt inte produceras i tillräckligtsnabRed blood cells are are plentiful, flexible and essential. They are the most abundant cell in our body and their mainobject is to carry oxygen, which is essential for cellular respiration. The formation of red blood cells is callederythropoiesis. Erythropoiesis is intimately coupled to cell division and mitochondrial function. Aberrations in thesetwo processes are often associated with red blood c

Background: Currently, hand-held gamma cameras are being developed for 99mTc imaging, mainly for sentinel lymph node detection. These cameras offer advantages, such as mobility and ease of access, and may be useful also for other applications such as biokinetic studies in animals or for imaging of small, superficial structures in patients. In this work, the suitability of a CZT-based hand-held cam

Objectives: The aims were to identify patients with rheumatoid arthritis (RA) who had stopped drinking alcohol and compare them with patients drinking alcohol, and to explore reasons for stopping drinking alcohol. Design: A sequential explanatory mixed methods design was used. Setting: Six rheumatology clinics in Southern Sweden Better Anti-Rheumatic FarmacOTherapy cohort. Participants: A total of

Breast cancer is now the most frequently diagnosed cancer in the world. Breast cancer prevention has gained increasing attention due to increasing breast cancer incidence rates in the West and can be actualized through lifestyle modifications or targeted interventions. Mammographic breast density (MBD) is a well-established independent breast cancer risk factor that is not well-understood on a mol

Surgical systems are complex and susceptible to external system pressures. The SARS-CoV-2 pandemic and its impact on elective surgery illustrated this. The reassignment of resources to the acute care of patients with COVID-19 led to cancellations of elective services that varied according to surges of the pandemic. Overall, it was estimated that more than 28 million operations were cancelled or po

BackgroundIn health care workers SARS-CoV-2 has been shown to be an occupational health risk, often associated with transmission between health care workers. Yet, insufficient information on transmission dynamics has been presented to elucidate the precise risk factors for contracting SARS-CoV-2 in this group.MethodsIn this cross-sectional study, we investigated association between questionnaire a

CONTEXT: Neurotensin is associated with cardiometabolic diseases but its role with mortality risk in humans is unknown.OBJECTIVE: This work aims to examine the prediction of proneurotensin (Pro-NT) with respect to total and cause-specific mortality in a middle-aged cohort.METHODS: In the population-based middle-aged cohort (n = 4632; mean age, 57 years) of the Malmö Diet and Cancer Study, Pro-NT w

Background: Capecitabine- or 5-fluorouracil (5-FU)-based chemotherapy is widely used in many solid tumours, but is associated with cardiotoxicity. S-1 is a fluoropyrimidine with low rates of cardiotoxicity, but evidence regarding the safety of switching to S-1 after 5-FU- or capecitabine-associated cardiotoxicity is scarce. Patients and methods: This retrospective study (NCT04260269) was conducted

Popular Abstract in Swedish Stamcellsbiologi är ett vetenskapligt, kliniskt och politiskt aktuellt ämne idag. Nuförtiden används blodstamceller för att behandla patienter med blod-cancer, bröstcancer eller andra immun-försvarssjukdomar. Blodstamceller finns i benmärgen och är viktiga för blodbild-ning som pågår kontinuerligt genom hela livet hos en individ. Det finns olika slags mogna celler: rödaHematopoietic Stem Cells (HSCs) have been defined to have abilities of both self-renewal and multi-lineage differen-tiation. The balance between these abilities is rigorously controlled under steady-state status (homeostasis) and when the normal processes of self-renewal and differentiation become deregulated, a disorder of blood system (such as leukemias) can occur. HSCs are enriched in lineage n

In this work, we present a ridged, microfabricated, force sensor that can be used to investigate mechanical interactions between cells exhibiting contact guidance and the underlying cell culture substrate, and a proof-of-function evaluation of the force sensor performance. The substrates contain arrays of vertical pillars between solid ridges that were microfabricated in silicon wafers using photo

Wrap Your Troubles into Dreams, är ett praktikbaserat forskningsprojekt. Undersökningen berör stadsomvandlingsprocesser i Stockholmsområdet, speglade genom två politiska förhållningssätt gestaltat i staden: genomförandet av det funktionsseparerade Stockholms City (under 1960-talet) och de senaste decenniernas privatisering av stadsrummet. I forskningen har jag utgått från två platser som i motreakWrap Your Troubles into Dreams is a practice-based artistic research project. The study investigates city transformation processes in the Stockholm area, by viewing them through two political attitudes expressed in the city; the introduction of the function-separated Stockholm City area (during the 1960s) and the privatisation of urban space during the last few decades. I have based my research on

Radionuclide therapy (RNT), is important for the treatment of certain benign and malignant diseases. 90Y-Zevalin™ therapy has become an established method of treating patients with non-Hodgkin B-cell lymphoma. Several observ¬ations regarding the outcome of therapy have prompted the use of higher absorbed doses by administering larger amounts of activity than those indicated in standard protocols.

The severe fouling common in food processing puts high demands on equipment cleaning. Adsorption of the protein betalactoglobulin to solid surfaces and its subsequent removal were followed using in situ ellipsometry. Most experiments were done in a stirred cuvette. Additionally, a flow cell was designed, which was employed in some work. The characteristics of the surface were shown to influence p

Popular Abstract in Swedish Den gynekologiska hälsokontrollen har medfört att incidensen av invasiv cervix-cancer kunnat halveras på 20 år i Sverige. Trots detta inträffar fortfarande mellan 5 - 600 nya fall av invasiv cervix-cancer årligen. Dessvärre tillhör en icke så litendel av dessa patienter tidigare cytologiskt kontrollerade kvinnor. Ralf Richard, New York, har på 70-talet ingående studera3,100 non-pregnant women and 85 pregnants were miniconized during the 15-year period ending 1994 . The outpatient procedure of minimal conization using a freehand-guided, high power 60W carbon dioxide laser focused to 0.1 mm in spot-size, giving high power density 165,000 W/cm2, produces single-piece tissue specimens for histological examination. The procedure is performed under local anaesthesia

The effects of organic pollutants on the soil microbial community were studied in this work. The main aim was to evaluate the use of pollution-induced community tolerance (PICT) in studying the effects of pollution. The leucine incorporation technique (indicating bacterial growth) was used to monitor changes in tolerance. The impact of toxic substances on bacterial and fungal growth (acetate-in-er

Popular Abstract in Swedish Avhandlingen tar upp polariserade plats-koncept (place/non-place, place/placelessnes, place/site etc. En modaliserande approach prövas, dvs nyanser och aspekter framhålls som alternativ till polariteter och dikotomier. Del 1 innefattar platsteori genom Edward Casey, Edward Relph, Kenneth Frampton, Perla Korosek-Serfaty och Henri Lefebvre. Här görs en kritisk läsning av In this thesis the notion of place is studied by way of investigating the “non-place” which is excluded or opposed, whenever a place is defined. “Non-place” is used here as a meta-concept, covering various recurring types of opposition to “place,” and it therefore represents a profoundly incoherent spect-rum of realities and concepts. Hence, a “non-place” may in this investigation appear as “lefto

Surface complexation of orthophosphate ions at the water-suspended-and-aged gamma-Al2O3/water interface has been studied by means of a series of batch experiments in 0.1 M Na(Cl) medium at 25.0 degrees C in the range 4.8 < -log [H+] < 9.6. The ratio between phosphate concentration and concentration of surface active groups (=AlOH) was varied between 0.15 and 1.50. The suspensions were equilibrated

The overall purpose with this work is to study the flow past particles and droplets using numerical simulations. Especially the interaction among particles and droplets have been a main objective as the results are to be used in order to improve already existing spray models. In order to represent the particulate and droplet phase, the Volume of Fluid (VOF) and the Volume of Solid (VOS) methods ar