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Objective: To study associations of clinical characteristics and treatment choice with functional outcome, mortality, and time to death in a national sample of aneurysmal subarachnoidal hemorrhage patients. Methods: Data were extracted from a prospective nationwide multicenter study performed in September 2014 to March 2018. Glasgow Outcome Scale Extended (GOSE) grade, 1-year mortality, and surviv

In many places, social movements and organised networks are the primary drivers of mobilisation for food sovereignty. Elsewhere, the concept has been institutionalized and incorporated into national food policy frameworks. However, there is a dearth of knowledge regarding places where food sovereignty efforts are spearheaded by NGOised civil society. This study addresses this gap by examining five

Hållbarhet och hållbar mobilitet har blivit viktiga mål i national politik och policy. Cykling har dock inte kunnat dra nytta av detta. Om man betraktar cyklingens betydelse under de senaste decennierna, och dess förväntade betydelse i framtiden, finns emellertid få anledningar till optimism, åtminstone inte på nationell och övergripande nivå; cykeln befinner sig fortfarande i skuggan av bilen. DeSustainability and sustainable mobility have become important political goals and have left their mark as important discourses in national policies and programs. Against expectations, cycling has barely benefited from this. Looking back over the shoulder at the significance of cycling over the last few decades and looking forward to suggested implications in the future give no reason for joy, at l

Coprophagy is a behavior where animals consume feces, and has been observed across a wide range of species, including birds and mammals. The phenomenon is particularly prevalent in juveniles, but the reasons for this remain unclear. One hypothesis is that coprophagy enables offspring to acquire beneficial gut microbes that aid development. However, despite the potential importance of this behavior

Carriers of BRCA1 germline pathogenic variants are at substantially higher risk of developing breast and ovarian cancer than the general population. Accurate identification of at-risk individuals is crucial for risk stratification and the implementation of targeted preventive and therapeutic interventions. Despite significant progress in variant classification efforts, a sizable portion of reporte

Objectives: This study explored the relation between external shame, two types of self-criticism, and depressive, anxious and stress symptoms, in a clinical sample. Specifically, we set out to test whether the impact of external shame on such symptoms would be mediated by two forms of self-criticism. Method: A total of 279 patients (228 female and 51 male; mean age of 28.58) with axis I and II dis

Background: Patients presenting with synchronous colorectal liver metastases are increasinglybeing considered for a curative treatment, and the liver-first approach is gaining popularity in thiscontext. However, little is known about the completion rates of the liver-first approach and itseffects on survival.Methods:A systematic review and meta-analysis of liver-first strategy for colorectal liver

OBJECTIVE: Determination of lactate in fetal scalp blood (FBS) during labour has been recognised since the 1970s. The internationally accepted cutoff of >4.8 mmol/l indicating fetal acidosis is exclusive for the point-of-care device (POC) LactatePro™, which is no longer in production. The aim of this study was to establish a new cutoff for scalp lactate based on neonatal outcomes with the use of t

Background: Characteristics and prognosis of patients admitted with strong suspicion of myocardial infarction (MI) but discharged without an MI diagnosis are not well-described. Objectives: To compare background characteristics and cardiovascular outcomes in patients discharged with or without MI diagnosis. Methods: The DETermination of the role of Oxygen in suspected Acute Myocardial Infarction (

Many glaciated valleys in Scotland contain distinctive, closely spaced ridges and mounds, which have been termed ‘hummocky moraine’. The ridges and mounds are widely interpreted as ice-marginal moraines, constructed during active retreat of mainly temperate glaciers. However, hummocky terrain can form by various processes in glacial environments, and it may relate to a range of contrasting glaciod

Objectives: To evaluate the changes in disease-related biomarkers and safety of paquinimod, an oral immunomodulatory compound, in patients with systemic sclerosis (SSc). Methods: In this open-label, single-arm, multicenter study, SSc patients with a rapidly progressive disease received paquinimod for 8 weeks. Blood and skin biopsies were collected at baseline, during treatment, and at follow-up fo

In response to the ongoing climate crisis, many countries have issued policies to support the uptake of renewable energy. In the same vein, the European Union (EU) has issued a revised renewable energy directive in 2018. One of the pillars of the directive is the support for community energy initiatives, i.e. sustainable energy initiatives run by or with the participation of citizens. The concept

High hyperdiploid acute lymphoblastic leukemia (ALL) is one of the most common malignancies in children. The main driver event of this disease is a nonrandom aneuploidy consisting of gains of whole chromosomes but without overt evidence of chromosomal instability (CIN). Here, we investigated the frequency and severity of defective sister chromatid cohesion—a phenomenon related to CIN—in primary pe

In parallel with an unprecedented progress in vascular and stem cell biology during the past two decades, our understanding of vascular calcification has evolved from being perceived as a harmless, passive deposition of minerals to what we now consider a highly regulated, cell-mediated process that is strongly associated with chronic kidney disease (CKD) and confers increased risk for incident car

Recently, a 1.83 Å crystallographic structure of nitrogenase was suggested to show N2-derived ligands at three sites in the catalytic FeMo cluster, replacing the three μ2 bridging sulfide ligands (two in one subunit and the third in the other subunit) (Kang et al. in Science 368: 1381–1385, 2020). Naturally, such a structure is sensational, having strong bearings on the reaction mechanism of the e

While many bumblebee species decline due to climate and land-use changes, others cope well with contemporary conditions. One example is Bombus terrestris, which is common in intensively managed agricultural landscapes. During the 20th century its subgenus, which includes the B. lucorum complex (B. lucorum, B. cryptarum and B. magnus) came to dominate Scandinavian bumblebee communities, but the spe

Distributed Decision Making and Control is a mathematical treatment of relevant problems in distributed control, decision and multi-agent systems, The research reported was prompted by the recent rapid development in large-scale networked and embedded systems and communications. One of the main reasons for the growing complexity in such systems is the dynamics introduced by computation and communi

Popular Abstract in Swedish Immunsystemet är vårt skydd mot främmande organismer såsom bakterier och virus. När vi får en förkylning, eller en infektion, tar immunsystemets celler hand om och dödar de invaderade mikroorganismerna. I normala fall märker vi endast av detta i form av att vi känner oss sjuka med eventuell feber som följd. Det ställs stora krav på immunsystemet. Det ska inte bara kunnaCollagen-induced arthritis (CIA) and pristane-induced arthritis (PIA) are animal models for human rheumatoid arthritis (RA), and can be induced in susceptible mouse and rat strains. CIA is induced by immunization of type II collagen (CII), a cartilage specific protein together with Freund’s adjuvant. PIA is induced by intradermal injection of pristane (2,6,10,14-tetrametylpentadecane). In rats, in

Popular Abstract in Swedish Målet med arbetet var att öka mängden vindkraft, solel och annan distribuerad generering (DG) som kan anslutas till befintliga distributionsnät på ett snabbt och kostnadseffektivt sätt. Att införa aktiv spänningsreglering i nätet, istället för installation av nya ledningar, har identifierats som en lämplig strategi. Då denna princip bygger på att DG-enheternas produktioDistributed generation (DG), i.e. generation connected to the low and medium voltage distribution network (DN), has been increasing a lot during recent years. Thus the traditional assumption of a unidirectional power flow and a voltage decrease along the distribution feeders is no longer valid in all operation conditions. Voltage control in these networks is often limited to the on-load tap change

Background and objectives: Food is the major factor driving the metabolism of the gut microbiota. In Mexico, nixtamalized corn products are widely consumed. Changes in antioxidant capacity (AOX) in 1,1-Diphenyl-2-picrylhydrazyl (DPPH) and Ferric ion reducing antioxidant power (FRAP), pH values, short-chain fatty acid concentration, and relative metabolite production during in vitro colonic ferment