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The PEPSI exoplanet transit survey (PETS) I : Investigating the presence of a silicate atmosphere on the super-earth 55 Cnc e

The study of exoplanets and especially their atmospheres can reveal key insights on their evolution by identifying specific atmospheric species. For such atmospheric investigations, high-resolution transmission spectroscopy has shown great success, especially for Jupiter-type planets. Towards the atmospheric characterization of smaller planets, the super-Earth exoplanet 55 Cnc e is one of the most

Safe and Healthy Para sport project (SHAPE): a study protocol of a complex intervention within Para sport

Elite Para athletes report a high incidence of sports injuries, illnesses and other health issues. Despite this, there are few prevention programmes in Para sport, and many of the existing prevention programmes are not adapted to Para athletes. To improve the success of preventive measures, it has been suggested that sports safety work should facilitate health promotion, including athlete health e

Insight into the dimer dissociation process of the Chromobacterium violaceum (S)-selective amine transaminase

One of the main factors hampering the implementation in industry of transaminase-based processes for the synthesis of enantiopure amines is their often low storage and operational stability. Our still limited understanding of the inactivation processes undermining the stability of wild-type transaminases represents an obstacle to improving their stability through enzyme engineering. In this paper

Energy transfer in multi-funnel systems quantitatively assessed by two-dimensional polarization imaging and single funnel approximation : From single molecules to ensembles

Two-dimensional polarization imaging (2D POLIM) is an experimental method where correlations between fluorescence excitation- and fluorescence emission-polarization properties are measured. One way to analyze 2D POLIM data is to apply a so-called single funnel approximation (SFA). The SFA allows for quantitative assessment of energy transfer between chromophores with identical spectra [homo-FRET (

Diffusion MRI of Brain Tissue: Importance of Axonal Trajectory

Obtaining microstructural information non-invasively on brain tissue remains a challenge. Diffusion magnetic resonance imaging (dMRI) is an imaging method that can provide such information. That includes geometrical considerations of nerve cells projections, axons, that are present in the white matter of the human brain. Axons carry information encoded into electrical impulses to other cells.The t

Locating Cities and their Governments in Multi-Level Sustainability Governance

Cities and their governments are increasingly recognized as important actors in global sustainability governance. With the adoption of the 2030 Agenda for Sustainable Development, their role in the global endeavor to foster sustainability has once again been put in the spotlight. Several scholars have highlighted pioneering local strategies and policies to implement the Sustainable Development Goa

Ideas with Histories : Traditional Knowledge Evolves

Abstract in FrenchDepuis longtemps, les anthropologues sont fascinés par les adaptations similaires et les différences intrigantes des cultures circumpolaires. Ces tendances ont été cartographiées, étudiées et interprétées sous différents angles, souvent à des niveaux sociaux ou spatiotemporels différents. Même si ces études ont produit d’importantes quantités de données, celles-ci ne couvrent pas

Attitudes towards welfare and environmental policies and concerns: A matter of self-interest, personal capability, or beyond?

In times of emergent emphases on how climate change will affect welfare societies, welfare policies and individuals’ welfare and vice versa, this study investigates public support for welfare and environmental policies and concerns. Since previous research and literature have pointed towards a socioeconomic divide between the welfare agenda and the environmental agenda in terms of public support,

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Active generative cooling based on supercritical hydrocarbon fuel is regarded as one of the most promising methods for scramjet thermal management. A large eddy simulation method is used to explore the transient change law of the initial flow, and heat transfer behaviors of supercritical hydrocarbon fuel is in rectangular channels. An oscillation effect can be proved in the convective heat transfe

A Brake System Coefficient of Friction Estimation Using 3D Friction Maps

The coefficient of friction (COF) is one of the core factors in the evaluation of brake system performance. It is challenging to predict the COF, since it is strongly influenced by several parameters such as contact pressure (p), slip rate (v) and temperature (T) that depend on the driving conditions. There is a need for better models to describe how the brake friction varies under different drivi

Access-Based Consumption in the Built Environment: Sharing Spaces

The pressing need to implement a more circular economy has led to advancements in the research field. In the spatial context, sharing spaces and access-over-ownership models have the potential to mitigate the detrimental environmental impacts of space use. This study aims to adapt an existing theoretical framework on access-based consumption to the spatial context. We utilise a qualitative case st

Search, save and share: family historians’ engagement practices with digital platforms

Alongside established heritage institutions, family historians are central figures in the ecosystem of digital heritage, both as contributors to and users of digitized historical sources. With that in mind, this research aims for a wide examination of family historians’ engagement with the broader selection of available digital platforms, providing knowledge about how and why they choose to use on

Association of thyroid function with blood pressure and cardiovascular disease : A mendelian randomization

Thyroid function has a widespread effect on the cardiometabolic system. However, the causal association between either subclinical hyper-or hypothyroidism and the thyroid hormones with blood pressure (BP) and cardiovascular diseases (CVD) is not clear. We aim to investigate this in a two-sample Mendelian randomization (MR) study. Single nucleotide polymorphisms (SNPs) associated with thyroid-stimu

Structural basis of activation and antagonism of receptor signaling mediated by interleukin-27

Interleukin-27 (IL-27) uniquely assembles p28 and EBI3 subunits to a heterodimeric cytokine that signals via IL-27Rα and gp130. To provide the structural framework for receptor activation by IL-27 and its emerging therapeutic targeting, we report here crystal structures of mouse IL-27 in complex with IL-27Rα and of human IL-27 in complex with SRF388, a monoclonal antibody undergoing clinical trial

Physiotherapists' experiences of osteoarthritis guidelines in primary health care - an interview study

BACKGROUND: Osteoarthritis is a common joint disease, globally. Guidelines recommend information, exercise and, if needed, weight reduction as core treatment. There is a gap between evidence-based recommended care for osteoarthritis and clinical practice. To increase compliance to guidelines, implementation was conducted. The aim of the study was to explore physiotherapists' experiences of osteoar

Global epidemiology of vasculitis

The many forms of vasculitis are characterized by inflammation of blood vessels, leading to potentially long-term sequelae including vision loss, aneurysm formation and kidney failure. Accurate estimation of the incidence and prevalence has been hampered by the absence of reliable diagnostic criteria and the rarity of these conditions; however, much progress has been made over the past two decades

Streptococcus bovis-bacteremia: subspecies distribution and association with colorectal cancer : a retrospective cohort study

This study aimed to describe the incidence of Streptococcus bovis/Streptococcus equinus complex (SBSEC) bacteremia, distribution of the SBSEC subspecies, and their respective association with colorectal cancer (CRC). A population-based retrospective cohort study of all episodes of SBSEC-bacteremia from 2003 to 2018 in Skåne Region, Sweden. Subspecies was determined by whole-genome sequencing. Medi

Quantitative assessment of environmental sensitivity to desertification using the modified medalus model in a semiarid area

Iran is mainly located in the arid and semiarid climate zone and seriously affected by desertification. This is a severe environmental problem, which results in a persistent loss of ecosys-tem services that are fundamental to sustaining life. Process understanding of this phenomenon through the evaluation of important drivers is, however, a challenging work. The main purpose of this study was to p