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Animals across phyla can detect early cues of infection in conspecifics, thereby reducing risk of contamination. It is unknown, however, if humans can detect cues of sickness in people belonging to communities with whom they have limited or no experience. To test this, we presented Western faces photographed two hours after the experimental induction of an acute immune response to one Western and
The rooms in Intensive Care Units are considered as high-tech environments and believed to affect recovery process and wellbeing of patients. Moreover, the design and interiors affect the interplay between the patient and the next of kin. Objective: The aim of this study was to describe and interpret the meanings of the intensive care patient room as experienced by next of kin. Design: Next of kin
Based on the experiences of insufficient burnout in industrial fluidized bed furnaces despite adequate mixing and availability of oxidizer, the influence of potassium on CO and H2 oxidation in combustion environments was investigated. The combustion environments were provided by a laminar flame burner in a range relevant to industrial furnaces, i.e. 845 °C to 1275 °C and excess air ratios ranging
OBJECTIVE: The Diabetes Prevention Program (DPP) trial investigated rates of progression to diabetes among adults with prediabetes randomized to treatment with placebo, metformin, or intensive lifestyle intervention. Among women in the DPP, diabetes risk reduction with metformin was greater in women with prior gestational diabetes mellitus (GDM) compared with women without GDM but with one or more
OBJECTIVES: To determine whether national antiretroviral therapy (ART) coverage is associated with changes in the living arrangements of older adults.DESIGN: Retrospective analysis using 103 nationally representative surveys from 28 African countries between 1991 and 2015.METHODS: The sample consisted of individuals aged at least 60 years. We investigated how three measures of living arrangements
This article looks to the philosophy of Gilles Deleuze in order to theorize the crucifixion of Jesus as event in early Christian literature. A Deleuzian view on the event is primarily articulated with the distinction between a sequential and a serial understanding of happenings, where the latter forms the basis for singular events. It is argued that Jesus' death is best considered a singular event
Humanity is facing increasingly complex sustainability challenges. It is now clear that they cannot be resolved by new technology, policy or governance approaches alone. They require a broader, cultural shift. Consequently, the role of human beings' "inner dimensions" (e.g., their mindsets, worldviews, beliefs, social values, and motivations) and their potential "inner transformation" (embodied in
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease. Anti-citrullinated protein antibodies (ACPA) are crucial for the serological diagnosis of RA, where Epstein-Barr virus (EBV) has been suggested to be an environmental agent in triggering the onset of the disease. This study aimed to analyse antibody reactivity to citrullinated EBV nuclear antigen-2 (EBNA-2) peptides from three dif
Objective: To survey potential predictors of success of mandibular advancement device (MAD) therapy in patients with obstructive sleep apnea (OSA), and in particular, to examine anatomical narrowings and sleep-related collapse levels in the upper airway. Methods: This was a prospective study of 62 OSA patients (median apnea–hypopnea index [AHI] of 34), who were treated with a custom-made, monobloc
We have devised a new efficient approach tocompute combined quantum mechanical (QM) and molecularmechanical (MM, i.e. QM/MM) ligand-binding relative freeenergies. Our method employs the reference-potentialapproach with free-energy perturbation both at the MMlevel (between the two ligands) and from MM to QM/MM(for each ligand). To ensure that converged results areobtained for the MM → QM/MM perturb
Three-dimensional surveys are required to accurately resolve structures in very complex areas. In many cases the 3-D data set is collated from a series of parallel 2-D survey lines, and frequently the distance between the lines is more than the electrode spacing along the lines. The inversion of such data sets frequently produce models with banded near-surface anomalies that are aligned parallel (
In Scandinavia, the folklore collection of the nineteenth and early twentieth centuries coincided with rapid changes in political, economic, and social organization, and resulted in national collections of extraordinary scope. Although some later folklorists have expressed skepticism about the usefulness of these collections as resources for the study of folklore, ethnography and intellectual hist
Relapse of acute myeloid leukemia (AML) remains a significant clinical challenge due to limited therapeutic options and poor prognosis. Leukemic stem cells (LSCs) are the cellular units responsible for relapse in AML, and strategies that target LSCs are thus critical. One proposed potential strategy to this end is to break the quiescent state of LSCs, thereby sensitizing LSCs to conventional cytos
Objective: Measurement of fetal scalp blood lactate is a supplementary tool to cardiotocography in the case of a non-reassuring tracing. Several hand-held lactate meters have been launched, all with differentials in absolute values. Therefore, the reference intervals must be calculated for each device. The internationally accepted reference interval is based on measurement with Lactate ProTM with
Chronic pancreatitis should be managed medically until a surgical correctable complication develops. The ‘ideal’ operation should have a low mortality and morbidity, be easy to perform, provide pain relief, rectify the structural abnormalities such as bile duct obstruction, and not augment exocrine and endocrine insufficiency. Direct measurements made at the time of laparotomy have shown that at l
Cerebrospinal fluid (CSF) p-tau181 (tau phosphorylated at threonine 181) is an established biomarker of Alzheimer’s disease (AD), reflecting abnormal tau metabolism in the brain. Here we investigate the performance of CSF p-tau217 as a biomarker of AD in comparison to p-tau181. In the Swedish BioFINDER cohort (n = 194), p-tau217 shows stronger correlations with the tau positron emission tomography
A difference in female pheromone production and male behavioral response has previously been found in two populations of the turnip moth, Agrotis segetum, originating from Sweden and Zimbabwe, respectively. In this study, we investigated the pheromone response of antennal lobe interneurons of males of the two populations by intracellular recordings, stimulating with single pheromone components and
