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Global warming has greatly stimulated vegetation growth through both extending the growing season and promoting photosynthesis in the Northern Hemisphere (NH). Analyzing the combined dynamics of such trends can potentially improve our current understanding on changes in vegetation functioning and the complex relationship between anthropogenic and climatic drivers. This study aims to analyze the re
BACKGROUND: Falls are common among older persons and can have a major impact on their lives. Wearable sensors used in free-living conditions (moving naturally in one's daily living environment) can be used to predict falls and fall risks. To understand if using the wearable sensors is an acceptable way for older persons to be screened for fall risks, it is important to have knowledge of older pers
BackgroundThe primary aim of specialised palliative care (SPC) is to improve the quality of life (QoL) for patients with a high symptom burden from a life-threatening disease. This randomised study aimed to assess the QoL impact of early integration of SPC alongside tumour-specific palliative treatment in patients with gastrointestinal (GI) cancers.MethodsWe randomly assigned ambulatory patients w
Near-haploidization, that is, loss of one copy of most chromosomes, is a relatively rare phenomenon in most tumors, but is enriched among certain soft tissue sarcomas, including undifferentiated pleomorphic sarcoma (UPS). Presumably, near-haploidization can arise through many mechanisms. This study aimed to identify gene rearrangements that could cause near-haploidization. We here present two UPS
Introduction: A subgroup of severe Traumatic Brain Injury (TBI) patients, known as ultra-severe (us-TBI), is most commonly defined as a post-resuscitation Glasgow Coma Scale (GCS) of 3–5. There is uncertainty on whether these critically injured patients can benefit from neurosurgical intervention. Research question: The available evidence regarding the decision-making and outcome following managem
Background: Summary statistics often hide individual patients' suffering, thereby impeding quality improvement efforts. Objectives: We aimed to show the experience of a population with health care toward the end of life while preserving the experience of the individual. Design: We developed a data display method called per-patient illness trajectory analysis. We tested it using a demonstration coh
ADP-ribosylation is involved in the regulation of DNA repair, transcription, and other processes. The 18 human ADP-ribose transferases with diphtheria toxin homology include ARTD1/PARP1, a cancer drug target. Knowledge of other family members may guide therapeutics development and help evaluate potential drug side effects. Here, we present the crystal structure of human ARTD15/PARP16, a previously
In the CONVINCE trial, the primary analysis demonstrated a survival benefit for patients receiving high-dose hemodiafiltration (HDF) as compared with high-flux hemodialysis (HD). A secondary objective was to evaluate effects on health-related quality of life (HRQoL); assessed in eight domains (physical function, cognitive function, fatigue, sleep disturbance, anxiety, depression, pain interference
Purpose - The purpose of this paper is to acquire strict upper and lower bounds on quantities of slender beams on Winkler foundation in finite element analysis. Design/methodology/approach - It leans on the dual analysis wherein the constitutive relation error (CRE) is used to perform goal-oriented error estimation. Due to the coupling of the displacement field and the stress field in the equilibr
Silica has rarely been used as a seed particle material in acoustic trapping of nanoparticles. Here we use fluorescent nanoparticles, which are frequently used as a model system, to demonstrate that throughput and nanoparticle trapping efficiency can be improved by using silica seed particles as opposed to traditionally used polystyrene seed particles. The 10 times larger dipole scattering coeffic
Over the world, there is growing worry about the corrosion of reinforced concrete structures. Structure repair, rehabilitation, replacement, and new structures all require cost-effective and long-lasting technologies. Fiber Reinforced Polymer (FRP) has been widely employed in both retrofitting existing structures and building new ones. Due to its varied qualities in reinforced concrete and masonry
Background: The core of postnatal care is that midwives recognise the needs of women and new-born babies and provide the highest possible quality of care and medical safety to optimise the health and well-being of new families. The study aimed to describe midwives' experiences in providing postnatal care for families during the first week after the birth of their baby. Methods: An interview study
Background: A diagnosis of prostate cancer (PC) may cause psychosocial distress not only in a man but also in his intimate partner. However, long-term risks of depression, anxiety, or suicide in partners of men with PC are largely unknown. Methods: A national cohort study was conducted of 121 530 partners of men diagnosed with PC during 1998-2017 and 1 093 304 population-based controls in Sweden.
Antibiotic resistance is a global health crisis that requires urgent action to stop its spread. To counteract the spread of antibiotic resistance, we must improve our understanding of the origin and spread of resistant bacteria in both community and healthcare settings. Unfortunately, little attention is being given to contain the spread of antibiotic resistance in community settings (i.e., locati
Background: Delayed gastric emptying (DGE) is a common complication after pancreatoduodenectomy (PD). DGE causes prolonged hospital stay and a decrease in quality of life. This study analyzes predictive factors for development of DGE after PD, also in the absence of surgical complications. Method: Data from the Swedish National Pancreatic Cancer Registry for patients undergoing standard and pyloru
BackgroundDiabetes and prediabetes are well-recognized risk factors for cardiovascular disease (CVD) and are marked by vascular endothelial dysfunction (ED). However, there is a scarcity of thorough population-based studies examining ED in individuals with diabetes/prediabetes free from manifest CVD. Here, we examined the association between ED assessed by reactive hyperaemia index (RHI) in the fi
The highly infectious disease COVID-19 caused by the Betacoronavirus SARS-CoV-2 poses a severe threat to humanity and demands the redirection of scientific efforts and criteria to organized research projects. The international COVID19-NMR consortium seeks to provide such new approaches by gathering scientific expertise worldwide. In particular, making available viral proteins and RNAs will pave th
