Sökresultat

Herein we describe the discovery of ACP-105 (1), a novel and potent nonsteroidal selective androgen receptor modulator (SARM) with partial agonist activity relative to the natural androgen testosterone. Compound 1 was developed from a series of compounds found in a HTS screen using the receptor selection and amplification technology (R-SAT). In vivo, 1 improved anabolic parameters in a 2-week chro

The objective of this work is to compare the adherence to therapy of patients receiving etanercept and infliximab during first tumour necrosis factor (TNF)-blocking treatment course in rheumatoid arthritis. Special emphasis is placed on potential predictors for treatment termination and the impact of concomitant methotrexate (MTX) or other disease-modifying antirheumatic drugs (DMARDs). Patients (

BACKGROUND: Employment is central to recovery in schizophrenia, but little attention has been paid to its relationship with cognitive functioning. OBJECTIVE: This cross-sectional study adds to the knowledge base of relationships between cognitive functioning and gaining competitive employment, work hours per week, and monthly income among people with schizophrenia in vocational rehabilitation. It

The world of cult cinema is dotted with numerous films that are often characterised by event-like evening screenings in independent or art-house cinemas years or even decades after the film’s initial release. One film synonymous with the cult cinema circuit is Tommy Wiseau’s The Room (2003), which has often been hailed as the ‘Citizen Kane of bad movies’ due to the film’s lack of artistic vision,

In this paper we discuss some recent and widely debated views of belief, comparing them with Ramsey’s, as it was developed in his classic papers and the posthumously published work On Truth. This paper is not purely historical. Modern views of belief, especially the theory of Shah and Velleman are examined, and it is shown that Ramsey’s views are relevant to the current discussion. Ramsey’s theory

Gruppundervisning sprids snabbt över världen, men lite forskning har utförts för att undersöka dess inverkan på elevers musikaliska förmågor jämfört med inkludering i gruppundervisningssammanhang. Den här artikeln undersöker hur musiklärare från den klassiska orkesterinstrumentala traditionen diskuterar gruppundervisning. Tre fokusgruppsintervjuer genomfördes med deltagare från en kulturskola i Sv

What role has music played in global colonial projects? And how has musical colonisation been implemented on a large scale? To address these questions, I analyse the work of the evangelical missionary administrators Christian Ignatius Latrobe (1756–1836) and Hans-Peter Hallbeck (1784–1840). Latrobe was a London-based music historian, composer and editor who oversaw the missionary work of the Morav

In times of increasing global temperatures and apathy in the face of climatic and social crises, understanding why people do or do not act is critical. Despite high pro-environmental attitudes, most people ignore the reality of climate change in their everyday lives (Moser & Kleinhückelkotten, 2017). This may be a sign for internal conflict and attempts to protect the self from threat (Norgaar

Aims. We report 20 new lithium-rich giants discovered within the Gaia-ESO Survey, including the first Li-rich giant with an evolutionary stage confirmed by CoRoT (Convection, Rotation and planetary Transits) data. We present a detailed overview of the properties of these 20 stars. Methods. Atmospheric parameters and abundances were derived in model atmosphere analyses using medium-resolution GIRAF

Aim: The overall aim was to investigate associations between bullying, violence and mental health among young people in Sweden. Specific aims were to investigate differences in exposure to peer victimization among disabled and non-disabled adolescents (Paper I), the influence of social support on the relationship between cyber harassment and mental distress among adolescents (Paper II), the associ

Objective: Recent research has shown that combining radiotherapy and immunotherapy can counteract the ability of cancer to evade and suppress the native immune system. To optimise the synergy of the combined therapies, factors such as radiation dose and fractionation must be considered, alongside numerous parameters resulting from the complexity of cancer-immune system interactions. It is instruct

A firm understanding of the coupling between the deformation on different scales within a material is key when formulating multi-scale constitutive models. In many polymers, the macroscopic deformation is, to a large extent, dictated by the underlying molecular structure and how this evolves during loading. To gain information ab out the behaviour of the molecular structure during deformation, non

Around 100,000 refugees are resettled to dozens of countries from conflict zones every year. While there is growing evidence that the initial placement of refugee families profoundly affects their lifetime outcomes, there have been few attempts to optimize resettlement destinations within host countries. We describe how machine learning and integer optimization can be used to empower resettlement

Comparative empirical studies of the link between economic growth, carbon emissions and ecological footprints (Koch and Fritz 2014; Fritz and Koch 2016) suggest that current Western production and consumption patterns and welfare standards are incompatible with environmental limits and IPCC climate targets. In the absence of evidence for absolute decoupling of economic growth, material resource in

Precipitation can be quantified using a rain gauge network, or a remotely sensed precipitation product. Ultimately, the choice of dataset depends on the particular application, the catchment size, climate and the time period of study. In a region with a long record and a dense rain gauge network, the elevation-modified ground-based precipitation product, PRISM, has been found to work well. However