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Accessibility and quality of drug company disclosures of payments to healthcare professionals and organisations in 37 countries: A European policy review

Objectives: To examine the accessibility and quality of drug company payment data in Europe.Design: Comparative policy review of payment data in countries with different regulatory approaches to disclosure.Setting; 37 European countries.Participants: European Federation of Pharmaceutical Industries and Associations, its trade group and their drug company members; eurosfordocs.eu, an independent da

Development and validation of a lifestyle-based model for colorectal cancer risk prediction : the LiFeCRC score

Background: Nutrition and lifestyle have been long established as risk factors for colorectal cancer (CRC). Modifiable lifestyle behaviours bear potential to minimize long-term CRC risk; however, translation of lifestyle information into individualized CRC risk assessment has not been implemented. Lifestyle-based risk models may aid the identification of high-risk individuals, guide referral to sc

Diffusion-encoded MRI for assessment of structure and microcirculation : Aspects of q-space imaging and improved IVIM modelling

Blodet bär med sig syre och näringsämnen som är vitala för vävnadens överlevnad, och därför är karakterisering av hjärnans blodförsörjning av stor betydelse. Blodflödet i kapillärerna kallas för perfusion. Vid MRI-baserad perfusionsmätning i hjärnan utnyttjas ofta signalförändringar orsakade av ett spårämne i blodet. Spårämnet kan antingen skapas internt genom märkning av det arteriella inflödet aDiffusion and perfusion MRI are valuable methods for investigating the microstructure and viability of tissue. One pure diffusion study was included in this thesis, with the purpose of studying microstructure and carrying out size estimations with the q-space diffusion imaging method. This is a method that has predominantly been explored with NMR spectrometers. In our study, a biological phantom c

Effects of eye movement modeling examples on adaptive expertise in medical image diagnosis

Research indicates that expert performance is domain specific and hardly transfers to novel tasks or domains. However, due to technological changes in dynamic work settings, experts sometimes need to adapt and transfer their skills to new task affordances. The present mixed method study investigates whether eye movement modeling examples (EMME) can promote adaptive expertise in medical image diagn

Statistical Tragedy in Africa?

What do we know about economic development in Africa? The answer is that we know much less than we would like to think. This collection assesses the knowledge problem present in statistics on poverty, agriculture, labour, education, health, and economic growth. While diverse in origin, the contributors to this book are unified in two conclusions: the quality and quantity of data needs to be improv

Time-resolved tracking of the atrioventricular plane displacement in Cardiovascular Magnetic Resonance (CMR) images

BACKGROUND:Atrioventricular plane displacement (AVPD) is an indicator for systolic and diastolic function and accounts for 60% of the left ventricular, and 80% of the right ventricular stroke volume. AVPD is commonly measured clinically in echocardiography as mitral and tricuspid annular plane systolic excursion (MAPSE and TAPSE), but has not been applied widely in cardiovascular magnetic resonanc

Science - policy interfaces in impact assessment procedures

Modelling tools used in impact assessment procedures can be regarded as tools for communication between science and policy. In order to create an integrated system for modelling not only the scientific components have to be in place but also the science/policy interfaces in the assessment procedures have to be identified and their social dynamics understood.To make a system like SEAMLESS Integrate

Intelligent systems in health care : A socio-technical view

This chapter reflects on the relationship between various stakeholders in the health-care industry and intelligent medical systems. It takes into consideration the potential impact that intelligent systems have on health care. The aim of the chapter is to emphasise a set of decisive factors for the successful deployment of intelligent systems in health care including the individual needs of patien

Can RE Help Better Prepare Industrial AI for Commercial Scale?

This issue marks the start of my term as department editor for the “Requirements” column. I very much look forward to exploring contemporary aspects of requirements and requirements engineering (RE) in the coming years! As an institute researcher with RISE, I primarily work in strictly regulated domains, in which requirements are cornerstones in the development activities. Please check my introduc

Experimental and modeling study of NO formation in ethyl formate + air flames

Premixed ethyl formate + air flames have been investigated at atmospheric pressure and initial temperatures from 298 to 348 K. The burning velocities were determined using the heat flux method for equivalence ratios from 0.6 to 1.5 and were compared with limited data available in the literature and with measurements for the C3H6O2 isomer, methyl acetate, obtained under the same conditions. In ethy

Genetic risk of type 2 diabetes modifies the effects of a lifestyle intervention aimed at the prevention of gestational and postpartum diabetes

Aims/hypothesis: The aim of this study was to assess the interaction between genetic risk and lifestyle intervention on the occurrence of gestational diabetes mellitus (GDM) and postpartum diabetes. Methods: The RADIEL study is an RCT aimed at prevention of GDM and postpartum diabetes through lifestyle intervention. Participants with a BMI ≥30 kg/m2 and/or prior GDM were allocated to intervention

BeChange: Sustainability education and leadership development : Assessing the links between inner development and outer change for transformation

This report presents the assessment of a six-week online course offered by BeChange, which was given from April to June in 2022. Through a total of five online sessions, an interactive learning platform, diverse practices and individual coaching, the course aimed to support participants in reducing their CO2 emissions, increase their climate engagement, and at the same time enhance their wellbeing

Trust-Based Public Management : Conceptualization and lessons from the Swedish trust reform

Following years of increasing bureaucracy and micro-management, there is a need for more trust in the judgement of street-level professionals and citizens in the public administration. After an intense debate in Sweden for several years, the Swedish Government launched a trust reform in 2016. This was organized around a government commission, called the Trust Commission. At the centre of its work

Rethinking refurbishment projects for improved users' working environment

The built environment is important to achieve a sustainable society. From a sustainability perspective, refurbishment can be preferable to building anew. A significant proportion of the built environment needs to be refurbished. Refurbishment projects also provide the opportunity to proactively upgrade the working environment for users during operation and use.Research concerning the working envir

Religion and Indias international relations

The chapter focuses on the religious aspects of India’s international relations by paying attention to four interrelated developments, discourses and narratives. First is the more general understanding of the role of religion in the Indian national narrative after independence, outlining how India’s policy of non-alignment and exceptionalism served as a site for a particular representation of Indi

A cognitive mess : Mixed feelings about wind farms on the Danish coast and the emotions of energy infrastructure opposition

The majority of local respondents in a large-scale survey were in favour of planned local wind farms on the Danish coast, despite these wind farm plans being the source of wider public and political contestation and opposition. Here we discuss results from the open-ended questions in the survey, specifically focusing on comments expressing how some respondents felt split in their views of these wi

Analysis of the SYSDIET Healthy Nordic Diet randomized trial based on metabolic profiling reveal beneficial effects on glucose metabolism and blood lipids

Background & aims: Intake assessment in multicenter trials is challenging, yet important for accurate outcome evaluation. The present study aimed to characterize a multicenter randomized controlled trial with a healthy Nordic diet (HND) compared to a Control diet (CD) by plasma and urine metabolic profiles and to associate them with cardiometabolic markers. Methods: During 18–24 weeks of inter

Temporal relationship between osteoarthritis and comorbidities : A combined case control and cohort study in the UK primary care setting

Objective: To determine the burden of comorbidities in OA and their temporal relationships in the UK. Methods: The Clinical Practice Research Datalink (CPRD) GOLD was used to identify people with incident OA and age, gender and practice matched non-OA controls from UK primary care. Controls were assigned the same index date as matched cases (date of OA diagnosis). Associations between OA and 49 in