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The potential effects of oral contraceptive (OC) and postmenopausal hormone (PMH) use are not well understood among BRCA1 or BRCA2 (BRCA1/2) deleterious mutation carriers with a history of breast cancer. We investigated the association between OC and PMH use and risk of contralateral breast cancer (CBC) in the WECARE (Women's Environment, Cancer, and Radiation Epidemiology) Study. The WECARE Study

Context.Innovation is promoted in companies to help them stay competitive. Four types of innovation are defined: product, process, business, and organizational. Objective. We want to understand the perception of the innovation concept in industry, and particularly how the innovation types relate to each other. Method. We launched a survey at a branch of a multi-national corporation. Results. From

Eeg-Olofsson K, Cederholm J, Nilsson PM, Zethelius B, Svensson A-M, Gudbjornsdottir S, Eliasson B (Institute of Medicine, Sahlgrenska University Hospital, University of Gothenburg, Gothenburg; Department of Public Health and Caring Sciences/Family Medicine and Clinical Epidemiology, Uppsala University, Uppsala; Department of Clinical Sciences, Lund University, University Hospital, Malmo; Departmen

Motor complications of Parkinson's disease (PD) are a consequence of pulsatile dopaminergic stimulation from standard oral levodopa therapy. Levodopa-carbidopa intestinal gel (LCIG) is infused continuously via an intrajejunal percutaneous gastrostomy tube. This was the first study designed to characterize the full pharmacokinetic profiles of levodopa, carbidopa, and levodopa metabolite, 3-O-methyl

Background: Cadmium, a common food pollutant, alters DNA methylation in vitro. Epigenetic effects might therefore partly explain cadmium's toxicity, including carcinogenicity, but human data on epigenetic effects are lacking. Objectives: To evaluate effects of dietary cadmium exposure on DNA methylation, considering other environmental exposures, genetic predisposition, and gene expression. Meth

Objective The objective of this study was to investigate whether a Medication Report also can reduce the number of patients with clinical outcomes due to medication errors. Method A prospective intervention study with retrospective controls on patients at three departments at Lund University Hospital, Sweden that where transferred to primary care. The intervention group, where patients received a

I denna artikel analyseras berättelser av 27 överlevande efter kriget i Bosnien och Hercegovina. Artikelns syfte är att dels analysera markeringar för försoning och oförsonlighet, dels beskriva de försoningsvillkoren som aktualiseras i berättelser. Den interaktiva dynamiken under kriget konstruerar försoningen efter kriget som förbunden med krigstiden. Berättelser om försoning blir en arena för ol

Background: Conflicting data exist regarding the prognostic and predictive impact of survivin (BIRC5) in breast cancer. We previously reported survivin cytoplasmic-to-nuclear ratio (CNR) as an independent prognostic indicator in breast cancer. Here, we validate survivin CNR in a separate and extended cohort. Furthermore, we present new data suggesting that a low CNR may predict outcome in tamoxife

The North Atlantic Oscillation (NAO), a measure of the strength of the zonal wind across the North Atlantic Ocean, strongly influences weather conditions in NW Europe, e.g. temperature, precipitation and wind, especially during winter. It was hypothesised that elevated concentrations of nitrogen oxides in Gothenburg would be enhanced during negative NAO index (NAOI) conditions, representing more a

An account is given of the general morphology, reproductive biology, ecology and historical exploration of the green alga order Oedogoniales. About 150 species belonging to the genera Oedogonium and Bulbochaete have been recorded from Sweden during the period 1864–1964. Notably, more than 80 taxa were described as new for science based on material from Swedish sites by the Scandinavian algologists

This thesis is based on four projects with the overall aim to investigate vitamin K-dependent protein S functions in relation to its structure. The anticoagulant functions of protein S can be divided in three: 1) cofactor for activated protein C (APC), 2) cofactor for tissue factor pathway inhibitor (TFPI) and 3) APC and TFPI-independent anticoagulant functions. Microparticles might be shed from

In the assessment of chest pain patients with suspected acute coronary syndrome (ACS) in the emergency department (ED), physicians rely on global diagnostic impressions ('gestalt'). The aim of this study was to determine the diagnostic value of the ED physician's overall assessment of ACS likelihood, and the values of the main diagnostic modalities underlying this assessment, namely the chest pain

Modern societies' functionality is strongly dependent on the electricity. Efficient, environment friendly, and economical power production has been in focus for a long time. The introduction of computers and thereby computer-aided tools for pre-design studies, optimization and choice of the best operational strategies, has changed the conditions for power production tremendously. The most noticeab

1. To investigate further the release, localization and identity of a non-nitrergic mediator of smooth muscle relaxation in the female pig urethra, we studied the effects of drugs acting at alpha 2-adrenoceptors or K+ channels, the effects of capsaicin and chemical sympathectomy, and the actions of several transmitter candidates. 2. Electrical field stimulation (EFS; frequencies above 12 Hz) of sp

Relict spinel grains (similar to 25-250 mu m in diameter) from decomposed extraterrestrial material in Archean to Recent sediments can be used to reconstruct variations in the flux of different types of meteorites to Earth through the ages. Meteorite falls are rare and meteorites weather and decay rapidly on the Earth surface, making it a challenge to reconstruct ancient fluxes. Almost all meteori

This essay investigates whether or not a governmental directive from 2012 con-cerning the use of citizenship in achieving better integration and a more dynamic Sweden, can be said to express Jürgen Habermas ideas of ‘constitutional patriot-ism’. The essay also scrutinizes how and if the directive’s ambition is achievable through the methods and means described therein, more specifically, the para-

Vi betraktar syntes och grendefekten av fyrlänks-mekanismer utifrån ett bergänsat antal task-positioner, baserat på kinematisk teori härledd från duala kvarternioner. Grendefekten är definierad som situationen där alla specificerade task-positionerna inte är sammankopplade av en kontinuerlig rörelse av mekanismens end-effector. Arbetsområ det av en fyrlänks-mekanism är härlett som snittet mellan tWe consider a finite position synthesis and branching avoidance of four-bar linkages based on kinematic theory derived from dual quaternions. The branching defect is defined as a situation where all specified task positions are not connected by a continuous motion of the linkage end effector. The workspace of a four-bar linkage is derived to be the intersection of two hyperboloids in the kinematic

Denna uppsats behandlar och syftar till att utreda möjligheten till umgänge mellan barn och dess mor- och farföräldrar, i enlighet med gällande svensk lagstiftning. Sådan umgängesrätt har genom de senare årtiondenas utveckling, enligt lagens ordalydelse, kommit att bli en rättighet tillägnad barnet. Enligt den tidigare gällande uppfattningen stod istället föräldrarnas intresse i fokus. UmgängesrätThis paper discusses the possibility of access between children and their grandparents according to Swedish law. In recent decades this access has become a right belonging to the child, according to the letter, in contrast to previous law where the parents’ interests were the priority. Since the reform in 1983 the right of access has become increasingly concentrated on the child’s needs and what i

Currently sedimentation is one of the major issues to deal with, for professionals, as it causes continuous loss of storage and hinder the intended purposes of a dam. More research and case-specific studies are required to understand the behavior of sediment transport mechanism in order to propose remedial measures. Sakuma dam on Tenryu River in Japan is one of the largest dams in Japan and it is