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Popular Abstract in Swedish Neuroblastom är den vanligaste solida tumören, utanför hjärnan, hos små barn och finns nästan inte alls hos vuxna. Varje år insjuknar mellan femton och tjugo barn i Sverige, de flesta före två års ålder. Överlevnaden har ökat de senaste tjugo åren men är fortfarande på låga nivåer för de mer aggressiva formerna. Neuroblastom uppstår i det sympatiska nervsystemet. DärförIn this thesis, the main focus has been on the childhood cancer neuroblastoma, one of the most common and lethal childhood tumours. Neuroblastoma has througout the years continued to be a clinical and biological enigma. Our first focus was on one of the most important biological risk factors in neuroblastoma -- amplification of the oncogene MYCN in the tumour cells. Because amplified MYCN typical

In this article we probe the effect of democratization on the state's administrative capacity. Using time-series cross-section data, we find a curvilinear (J-shaped) relationship between the two traits. The effect of democracy on state capacity is negative at low values of democracy, nonexistent at median values, and strongly positive at high democracy levels. This is confirmed under demanding sta

Background: The Btk (Bruton's tyrosine kinase) gene has been shown to be mutated in the human immunodeficiency disease, XLA (X-linked agammaglobulinemia). Btk is a member of the Tec family of cytosolic protein tyrosine kinases with distinct functional domains PH, TH, SH3, SH2, and kinase. Mutations have been observed in each of the Btk subdomains in XLA. We have analyzed the Btk gene in six XLA pa

Background: Panic Disorder with or without Agoraphobia is a commonly occurring disorder affecting 2-3% of the population in Sweden. Untreated, panic disorder is a chronic condition that significantly increases the risk for psychiatric comorbidity, morbidity and mortality, employment difficulties, and healthcare utilization. Cognitive behavioural approaches are the recommended first-line treatment

Two rotational bands have been identified and characterized in the proton-magic N = Z + 1 nucleus Ni-57. These bands complete the systematics of well-and superdeformed rotational bands in the light nickel isotopes starting from doubly magic Ni-56 to Ni-60. High-spin states in Ni-57 have been produced in the fusion-evaporation reaction Si-28(S-32, 2p1n)Ni-57 and studied with the gamma-ray detection

The area of public procurement has a significant financial impact on the Union market, proven by the fact that 18% of the Union’s GDP is spent by public authorities on resources that are regulated by the legislative framework surrounding public procurement. Such a significant spending therefore has the possibility of controlling the behaviour of the supply side on the market by demonstrating what

While culture “stresses social life as such: individuals in their relations to others” , this thesis paper deals with culture alongside notions of values, beliefs and national preference/interest. The cultural aspect will shed into light by a wider perspective – the influence it has among European Union´s social and political life. Within EU, the United Kingdom holds high gains and strong financia

Ett flertal olika faktorer – däribland utbildning, tidigare arbetserfarenheter och personliga egenskaper – avgör tillsammans en arbetssökandes attraktivitet på arbetsmarknaden. I regel står det arbetsgivare fritt att avgöra vilka kriterier som ska vara de mest avgörande på just deras arbetsplats. Vissa inskränkningar finns dock i denna frihet, däribland diskrimineringsförbudet. Inom den statliga There are several different factors – including education, working life experience and personal characteristics – that together determine how attractive a specific job applicant is on the labour market. In general, the employers can freely choose which criteria they value the most when they are recruiting. However, there are some restrictions that the employers need to take into consideration, the

Det svenska arbetslöshetsunderstödet tog form under sent 1800-tal efter initiativ från fackförbunden. En arbetslöshetsförsäkring under statlig kontroll grundlades först 1935. Den statliga arbetslöshetsförsäkringen, i fortsatt statlig regi, var i princip den enda regelbundna ersättningen som en arbetslös kunde erhålla under sin arbetslöshet fram till slutet av 1960-talet. Ett nytt omställningssysteThe Swedish unemployment benefits took shape during the late 1800s by an initiative from the trade unions. An unemployment insurance under state control became reality in 1935. The unemployment insurance was, during a couple of decades, virtually the only regular compensation an unemployed could receive during his or her unemployment. This changed during the 1960s. A complementary transition syste

In electric passenger vehicles with modest performance the drivetrain usually consists of one inverter, one electrical machine and a single-speed transmission. The inverter is typically a two-level inverter using either Si IGBT transistors with an anti-parallel Si diode, or a SiC MOSFET transistor with or without an anti-parallel diode. The benefits of selecting SiC MOSFET as semiconductor technol

The pathophysiology behind Complex Regional Pain Syndrome (CRPS) is not fully understood and associated factors and triggers for developing the condition are debated. We aimed to study such factors and long-term outcome in a descriptive cross-sectional study with a well-defined population with CRPS in the upper limb and related to sex and CRPS type. In retrospectively collected data from medical r

This master's thesis is about alternative career opportunities for library and information science graduates. Ever since the beginning of our education we have been interested in working outside of the traditional libraries. Now that we are about to receive our degrees in library and information science we are doubtful if the competence we have obtained is enough to meet the demands of the lab

A search for new phenomena has been performed in final states with at least one isolated high-momentum photon, jets and missing transverse momentum in proton–proton collisions at a centre-of-mass energy of s = 13 TeV. The data, collected by the ATLAS experiment at the CERN LHC, correspond to an integrated luminosity of 139 fb−1. The experimental results are interpreted in a supersymmetric model in