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Extrahepatic manifestations of chronic hepatitis C infection and the interrelationship between primary Sjogren's syndrome and hepatitis C in Swedish patients

OBJECTIVE: To analyse the frequency of some extrahepatic manifestations of chronic hepatitis C virus (HCV) infection in northern European patients, including a postulated association between HCV and primary Sjogren's syndrome (SS). DESIGN: Cohort study. SETTING: Department of Medicine, Malmo University Hospital, Sweden. PATIENTS: Twenty-one patients with HCV infection and 53 with primary SS (accor

Investigation and evaluation of a method for determination of ethanol with the SIRE (R) Biosensor P100, using alcohol dehydrogenase as recognition element

A new method for rapid determination of ethanol was developed, using alcohol dehydrogenase as recognition element for the SIRE (R) (sensors based on injection of the recognition element) Biosensor, which is an amperometric biosensor. The method was simple, fast, accurate, specific and cost-effective. The recognition element solution used was stable at least for 24h in room temperature, and at leas

Extra-Pair Paternity in the European Starling: The Effect of Polygyny

We determined the frequency of extra-pair paternity and intraspecific brood parasitism in European Starlings (Sturnus vulgaris) by performing multilocus DNA fingerprinting on 22 complete families from a population in southern Sweden. Among 92 nestlings, we did not detect any successful intraspecific brood parasitism. This confirms observational data that successful intraspecific brood parasitism i

Modernitet och intermedialitet i Erik Asklunds tidiga romankonst

Modernitet och intermedialitet is the first major study of the Swedish modernist writer Erik Asklund (1908-1980) and his works. The thesis consists of an introductory chapter and three close readings of Asklund’s early novels Kvinnan är stor (The Woman is Great, 1931), Lilla land (A Small Country, 1933), and Fanfar med fem trumpeter (A Fanfare with Five Trumpets, 1934). In these novels, Asklund de

Midterm clinical experience with a complex-shaped detachable platinum coil system for the treatment of cerebral aneurysms: Trufill DCS Orbit detachable coil system registry interim results

PURPOSE: To report an interim analysis of the registry data and evaluate the performance of Trufill DCS Orbit coils in terms of the stability of initial aneurysmal occlusion. MATERIALS AND METHODS: From May 1, 2004, to February 1, 2006, 291 patients with ruptured or unruptured aneurysms were enrolled in a multiple-center global registry from 37 centers in the United States, Europe, and Latin Ameri

Genome-wide structural and functional protein characterization by ab initio protein structure prediction

Popular Abstract in Swedish Många av alla kemiska processer som pågår i våra kroppar utförs av proteiner. När de inte fungerar blir vi sjuka. I vissa fall, till exempel vid Alzheimers sjukdom eller Creutzfeld Jacobs sjukdom, beror det på att ett visst protein har fel form. Att förstå hur proteiner antar sin slutliga form och vad det har för inverkan på proteinets funktion är således viktigt. ÅVery little is known about a considerable part of all proteins and it is time consuming and expensive to study each individual protein to determine its function, structure and cellular role. Proteins retain structural, functional and sequential characteristics from ancestral proteins and hence two proteins that share a common ancestor, i.e. are homologs, will to some extent have similar sequen

Development and Application of Laser Techniques for Studying Fuel Dynamics and NO Formation in Engines

Development and application of some laser techniques for the study of engine combustion are presented. The investigations mainly cover two aspects: fuel dynamics and formation of NO. Fuel dynamics is one of the most central problems in engine design since many performance parameters are affected by it; emission formation, efficiency, drivability etc. The studies include cycle-resolved measurement

Nanoxerography: nanostructured deposition of aerosol particles by charge printing

A method has been developed to transfer complex charge patterns to flat substrate surfaces, allowing nanostructured deposition of nanoparticles from the gas phase. Comparable to soft lithography, a stamp made of poly(dimethysiloxane) (PDMS), covered with a metal layer, is pressed on the surface of a silicon oxide on silicon substrate. Due to contact charging negative or positive charges are transf

Island biogeography and population divergence in the Skyros wall lizard

Popular Abstract in Swedish Öbiogeografi och populationsdifferentiering hos Skyros murödla Hur den fantastiska variationen som finns i naturen bildas är en fråga som länge fascinerat biologer. För mer än 150 år sedan inledde två välkända biologer, Charles Darwin och Alfred Russel Wallace, en brevväxling som skulle komma att bli startskottet för ett paradigmskifte. De hade båda fått idén om naturlIslands are cradles for new biodiversity and provide natural laboratories for the study of population divergence. In my thesis, I investigated the role of different evolutionary processes in the population divergence in the Skyros wall lizard (Podarcis gaigeae), a species where islet populations have strongly diverged morphologies. I used replicate islet populations and their respective most proxi

Lärarutbildningens olika undervisningspraktiker : En studie av lärarutbildares olika sätt att praktisera sitt professionella uppdrag

Popular Abstract in Swedish Denna avhandling syftar till att belysa vilket professionskunnande som blivande lärare ges möjlighet att utveckla under sin högskoleförlagda utbildning och hur detta professionskunnande kan karaktäriseras. Detta belyses genom ett antal forskningsfrågor: Vilka olika undervisningspraktiker konstituerar den högskoleförlagda lärarutbildningen? På vilket sätt upprättas dessaThe starting point for this dissertation was the reform of the school system in Sweden with consequences for teachers´ work and new demands on their professional knowledge. This thesis aims to illuminate the issue of what professional knowledge student teachers are offered during their time in the university, and how this professional knowledge can be characterised. This is carried out with respec

Existential Issues in Palliative Care

The main purpose of this dissertation is to describe how terminally ill patients experienced their situation, and what their views about the future were. Further, the experiences and attitudes of relatives of such patients, and of health care professionals, were also central. Focus was on existential issues, such as autonomy, meaning, guilt, relations, dignity, and communication. In the first pape

IMPROVISATÖRERNA – experimentella närmanden till improviserad opera som konstnärligt uttryck och redskap för pedagogisk utveckling

Opera improvisation at The Malmö Academy of Music has been a pedagogical and artistic experiment. This is the final account concerning this pedagogical and artistic research project. Singers who are studying classical singing at the bachelor and master programmes of theacademy have participated. The account includes historical and theoretical reflections on the subject and comments on the work in

Enhanced pharmacokinetic properties of a glycoPEGylated recombinant factor IX: a first human dose trial in patients with hemophilia B

Replacement therapy with factor IX (FIX) concentrates is the recommended treatment for patients with hemophilia B, an X-linked bleeding disorder occurring in 1: 25 000 male births. N9-GP is a recombinant FIX molecule with a prolonged half-life which is obtained by site-directed glycoPEGylation where a 40-kDa polyethylene glycol molecule is attached to the activation peptide of FIX. This first huma

Isolation of microbial natural products.

In principle, the isolation of secondary metabolites from microbes does not differ from their isolation from other organisms. The extraction procedure may of course be quite different, especially if it is carried out in an industrial scale, but when an extract containing the metabolites of interest is at hand, it is the same palette of adsorbents and chromatographic techniques that provide the maj

Phylogenetic characterization of microbial mats and isolation of Thermus spp. and sulfur-oxidizing bacteria from Icelandic hot springs

Until recently, the only way to describe microbial communities was by cultivation. This is a major obstacle because typically only a small fraction of the microbes can be cultivated by standard techniques. However, the use of rRNA and molecular phylogenetic techniques has allowed us to bypass this limitation. In this thesis, both of these approaches were used to describe the bacterial diversity o

EU, staten och rätten att straffa: Problem och principer för EU:s straffrättsliga lagstiftning

This is a thesis in Criminal Law, with the overall purpose to present an analysis of the legitimacy of the development in the criminal law area that has occurred within the framework of the European Union (EU). More specifically, the thesis will focus on the question of legitimacy of legislative power in criminal matters at the EU level – a question which ultimately is one concerned with the legit

Vilket svenskämne? Grundskolans svenskämnen i ett lärarutbildningsperspektiv

Popular Abstract in Swedish I "Vilket svenskämne? Grundskolans svenskämnen i ett lärarutbildningsperspektiv" beskrivs hur en grupp blivande 1 till 7-lärare förhåller sig till olika svenskämneskonceptioner genom lärarutbildningen. Avhandlingen har det dubbla syftet att analysera och tolka de studerandes svenskämneskonstruktioner och att institutionsanalytiskt granska utbildningen. Det empiriska matWhich Swedish? Swedish as a school subject, from the perspective of teacher training describes how a group of future teachers of years 1 to 7 of the compulsory school relates to various concepts of the subject Swedish through three courses delivered at the School of Education. The study has the aim of analyzing the students' construction of the subject of Swedish as taught in school, and to analys

Magnesium Chelatase: Insights into the first Step of Chlorophyll Biosynthesis

Popular Abstract in Swedish Enzymet magnesium-kelatas katalyserar bildandet av magnesium-protoporfyrin genom insättning av en magnesiumjon i protoporfyrin. Detta är det första unika steget i tillverkningen av klorofyll hos växter, alger och fotosyntetiska bakterier. Magnesium-kelatas består av tre proteiner som kallas I (vikt 40 kDa), D (70 kDa) och H (140 kDa). Det är viktigt att bestämma dessa pThe enzyme magnesium chelatase inserts magnesium into protoporphyrin IX (Proto) to produce to magnesium protoporphyrin IX, the first unique intermediate of the chlorophyll biosynthetic pathway. Magnesium chelatase is composed of three distinct proteins termed I (molecular weight ~40 kDa), D (~70 kDa) and H (~140 kDa). Defining the individual properties and structure of the magnesium chelatase comp