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Development and validation of prediction models for sentinel lymph node status indicating postmastectomy radiotherapy in breast cancer : population-based study

Background: Postmastectomy radiotherapy (PMRT) impairs the outcome of immediate breast reconstruction in patients with breast cancer, and the sentinel lymph node (SLN) status is crucial in evaluating the need for PMRT. The aim of this study was to develop and validate models to stratify the risk of clinically significant SLN macrometastases (macro-SLNMs) before surgery. Methods: Women diagnosed wi

The Impact of the Parental Patterns of Morbidity and Comorbidity in the Cross-Generational Transmission of Risk for Major Depression and Alcohol Use Disorder

To further understand the inter-relationship of the familial transmission of major depression (MD) and alcohol use disorder (AUD), we examine, via a multivariable Cox proportional hazards model, risks for AUD and MD in 1,244,516 individuals born in Sweden from 1970 to 1990 to intact mother-father pairs as a function of parental diagnoses of MD and/or AUD. Across the nine possible mating types, we

Understanding the child feeding decisions among urban parents : a qualitative study in addis ababa, Ethiopia

BACKGROUND: Food choice decisions are complex processes influenced by various factors that affect the family's diet and, thus, their health and nutrition. In low- and middle-income countries like Ethiopia, these factors are shaped by the ongoing nutrition transition, urbanization, and socio-economic challenges. Despite growing concerns about the double burden of malnutrition, the factors influenci

Conversion of glutamate into proline by the leucine analog BCH enhances biphasic insulin secretion in pancreatic β-cells

Biphasic insulin secretion, which fails in type 2 diabetes, can be provoked by various nutrient stimuli, glucose being the superior physiological one. To identify pathways that may play a role in β-cell stimulus-secretion coupling, we compared β-cell and islet functional, secretory, and metabolic responses to glucose and 2-aminobicyclo-(2,2,1)-heptane-2-carboxylic acid (BCH), a leucine analog, tha

Price transmission dynamics of Chinese ADRs listed on the NYSE

Purpose: This study aims to examine the price transmission among ADRs (American Depositary Receipts) and their underlying shares, US market index and Hong Kong market index. We will attempt to capture how a shock in the home market is transmitted to the foreign (and vice versa). In addition we will attempt to assess the relative weight of each variable in the system generating unexpected variation

Creating safety in a context of conflicting interests: The watch officer on board of a Dutch frigate

The watch officer on board of vessels of the Netherlands Royal Navy has to deal with a wide variety of interest during his/her duty. Despite the wide variety of interests the watch officer has to manage, the amount of incidents and accidents is few. Apparently, the watch officers of the Netherlands Royal Navy are well able to manage this wide variety of interests. The aim of this thesis research

Att bli den andra - En rättsnormativ diskursanalys om psykiskt utvecklingsstördas möjligheter till reproduktion under 1900-talet

The aim of this thesis was to study legislation from 1915, 1934, 1941 and 1999 about sterilization and marriage hinder of disabled individuals called ‘’feeble-minded’’. We have analyzed laws to examine if there are any existing discourses about disabled, and how the discourses have affected their lives and rights of reproduction. We also wanted to see what designations that where used to describe

Svensk fastighetsreglering - reglernas syfte och användning

Fastighetsbildningslagen (FBL) antogs 1970 och ersatte ett tiotal lagar gällande fastighetsbildningsåtgärder. Bestämmelserna kom nu att samlas och bli mer översiktliga. Ett nytt fastighetsbildningsinstitut som instiftades var fastighetsreglering. Detta institut skulle ersätta ägoutbytena som fanns i den äldre lagstiftningen. Tanken med ägoutbyte var att kunna utföra ömsesidiga byten av relativt smThe Swedish real estate law was adopted in 1970 and replacing the many existing laws regarding real estate measures. This lead to a better overview. A new real estate institute was about to take shape, which was to replace the old institute of change of land areas. The new institute, property reformation institute, was to be similar to the old one with the aim of exchanging small areas of land bet

Radiochromic Film Dosimetry in Kilovoltage X-­‐ray Beams: A Pre-­‐ Investigation for In Vitro Studies of Bystander Effects

Inom strålbehandling innebär den s.k. åskådareffekten ("bystander effect") ett relativt nytt tankesätt som betonar de biologiska effekterna av strålning på icke-bestrålade celler i närheten av bestrålade celler. Denna effekt har visat sig påverka inte bara de celler som angränsar till det bestrålade området utan även celler på större avstånd. I Lund pågår just nu ett projekt där man villPurpose Intensity modulation of radiation is one of several important conditions to evaluate for full understanding of how cells involved in the bystander effect influence each other when cells are exposed to radiation at low and high dose rates. The aim of this study was to develop and apply a useful and practical dosimetric method for measurement of the absorbed dose to cell cultures exposed to

The Concept of Taxable Transactions between Head Office and Branch - In the light of Skandia America

The CJEU recently enriched its case law concerning the concept of a single taxable person through its ruling in Skandia America. Established case law differentiate two concepts of single taxable person. According to FCE Bank, a head office and its branch are to be deemed as one single taxable person, with the result that no taxable supplies occur between these entities. In Ampliscientifica, the CJ

CLI Crawler

Many systems within the IT infrastructure have a Command Line Interface (CLI) for configuration changes. Some of these systems may expose a Configuration Management interface over a web service but this web service usually only exposes a fraction of the configuration possibilities in a CLI. Thus it would be of great help to investigate how a framework for automated CLI discovery can be developed,

Metodutveckling för regional tillsyn av LSO

This paper has been commissioned by the County administrative board of Skåne in order to provide them with a tool to support the evaluation of individual fire rescue services, according to the requirements of law 2003:778 1 chap 1 § concerning protection against accidents. Evaluation is understandably a key element in providing a functional service with perspective to enhance the abilities of the

JTAG-optimisation for CANoe

This master thesis investigates the possibilities to perform software validation tests on ECUs with customer-identical software. Instead of using a ”test specific” software which sends ”test specific” information on the CAN-bus this data is to be extracted from the target CPU by a JTAG debugger and integrated in the testing software CANoe. The benefit of this method is that it eliminates the probl

Kommunikation och samarbete över organisatoriska gränser - en studie inom ortopedin.

Sammanfattning I samhället pågår det ständigt en debatt om den svenska sjukvården och dess knappa resurser. Debatten tydliggör ett aningen bristande intresse för hur de olika professionerna verkligen försöker sammanfoga sina prestationer mot det gemensamma målet, patienten. Därför ämnar denna uppsats att ta reda på samt kartlägga kommunikationen mellan två olika professioner. Detta görs i syfte Abstract The Swedish health system and its lack of resources is a much debated issue in today’s society. The ongoing debate demonstrates a lack of interest in the question of how the different professions actually try to focus their actions towards the common goal, the patient. For this precise reason this present study aims to examine and charter communication between two such professions. This i

Visstidsanställningar i Sverige, på kollisionskurs med EU-rätten?

Den nuvarande svenska arbetsrätten kan vara på kollisionskurs med EU-rätten avseende tidsbegränsade anställningar när det gäller implementeringen av direktiv 99/70/EG. EU-kommissionen anser att det finns en kollision mellan direktivet och sättet det införlivats i nationell rätt. Det finns bärkraftiga argument att samma skyddsnivå som avses i direktivet uppfylls indirekt genom de svenska arbetsrättCurrent Swedish labor rules may be on a collision with the European legal rules concerning time-limited employments arising from the EU directive 99/70/EC. The view of the European commission is that the directive has not been fulfilled and properly incorporated in the national rules. There are valid arguments that the level of protection as intended in the directive is achieved, regardless of the

I kontakt med självhjälpsgrupper för anhöriga till missbrukare : En kvalitativ studie om vuxna barn

I denna studie har vi intervjuat tre kvinnor som levt under riskfyllda förhållanden i form av missbruk i större delar av sitt liv. Syftet med vår uppsats var att undersöka vilka erfarenheter anhöriga till missbrukare har av självhjälpsgrupper av typen ACA (vuxna barn till alkoholister och från andra dysfunktionella familjer) och dess stöd och hjälp. Vi formulerade tre frågeställningar där vi villeIn this study, we interviewed three women who have lived in hazardous conditions such as abuse in the greater part of their lives. The aim of this study was to examine what experiences relatives of abusers have of self-help groups such as ACOA (Adult Children Of Alcoholics and of other dysfunctional families) and its support and help. Due to our purpose we asked ourselves three questions: 1. how d

The spark of a movement - A study of an online collective acts potentiality to grow into a social movement

Social movements have become an integrated component in our western society with almost every contested issue having a social movement associated to it, on at least one side of the debate. When we think of social movements in practice, we might picture rallies and marches, chants, and demonstrations but with the emergence of social media more and more activists and movement adherents have moved to

Kartläggning av kväve i vatten i LKAB:s verksamhet i Malmberget år 2011 och kvävets betydelse i akvatiska ekosystem ur ett lokalt och ett globalt perspektiv

Populärvetenskaplig sammanfattning: Kvävecykeln är betydelsefull i ett globalt perspektiv eftersom den inverkar både på klimatet och olika ekosystemsprocesser. Den kan med andra ord beskrivas som kvävets kretslopp som beskriver de kemiska, fysiologiska, biologiska och geologiska processerna som sker i naturen. Dikväveoxid är en stark växthusgas och inverkar på klimatet då den precis som koldioxid The nitrogen cycle is included in the biogeochemical cycles that connect all the organisms in one giant ecosystem, the biosphere. The nitrogen cycle is important both in a global perspective where the greenhouse gas N2O affects the climate and in a local perspective where it controls different processes in ecosystems. The availability of nutrients also have a great influence on all aquatic ecosyst

ESR Essentials : post-treatment breast cancer surveillance from mammography to a more personalised approach-practice recommendations by the European Society of Breast Imaging

Abstract: The breast cancer long-term survival rate has improved; early detection of local recurrence and second primary cancers has been crucial to this success. Mammography is the standard imaging technique for follow-up, but its sensitivity is affected by breast density and post-treatment changes. This article discusses the role of mammography in the follow-up of women after breast cancer treat