Filtyp
Protein C inhibitor (PCI) and antithrombin (AT) are serine protease inhibitors (serpins) that are involved in the regulation of coagulation. Like other inhibitory serpins, PCI and AT adopt different structural conformations that are related to their functions. The cleaved, inactive form is a result of cleavage by a protease, and the latent form, which is also inactive, can arise due to a mutation
Objectives: To review case histories of patients in whom fibrosis played a significant role in the pathogenesis of their disease, and to determine whether intravenous gammaglobulin (IVIg) contributed to the regression of their fibrotic condition. Methods: Eight patients with excess fibrotic reaction in the course of diverse diseases were analysed; a tendency that reverted with different IVIg treat
Recent work on low-rank matrix factorization has focused on the missing data problem and robustness to outliers and therefore the problem has often been studied under the $L_1$-norm. However, due to the non-convexity of the problem, most algorithms are sensitive to initialization and tend to get stuck in a local optimum. In this paper, we present a new theoretical framework aimed at achieving opt
Energy security is one of the main drivers of energy policies. Understanding energy security implications of long-term scenarios is crucial for informed policy making, especially with respect to transformations of energy systems required to stabilize climate change. This paper evaluates energy security under several global energy scenarios, modeled in the REMIND and WITCH integrated assessment mod
Cognitive ability strongly aggregates in families, and prior twin and adoption studies have suggested that this is the result of both genetic and environmental factors. In this study, we used a powerful design-home-reared and adopted-away cosibling controls-to investigate the role of the rearing environment in cognitive ability. We identified, from a complete national Swedish sample of male-male s
Objective. The aim of this study was to present the outcome of patients treated with salvage cryotherapy after radiotherapy for prostate cancer at one institution. Materials and methods. Consecutive patients treated between 2007 and 2013 with transperineal cryotherapy for biopsy-verified local recurrence after radiotherapy were investigated. An external reviewer retrieved outcome data retrospectiv
In healthy subjects, acute inhalation of swine dust causes an influx of inflammatory cells into the airways and increased bronchial responsiveness. The exposure may also cause fever and generalized symptoms. It seems likely that proinflammatory cytokines are involved in the response to inhaled swine dust. Nasal and bronchoalveolar lavage (BAL) were performed before, and 7 and 24 h after the start
During drying, timber distortion is a major defect mainly due to shrinkage anisotropy, differences in longitudinal shrinkage, and spiral grain. The distortion can be reduced by external restraint and use of appropriate kiln schedules. The research presented here is part of a project on the improvement of shape stability of Norway spruce by high-temperature drying. The effects of drying temperature
We have estimated the activation energy for hydrogen abstraction by compound I in cytochrome P450 for a diverse set of 24 small organic substrates using state-of-the-art density functional theory (B3LYP). We then show that these results can be reproduced by computationally less demanding methods, for example, by using small organic mimics of compound I with both B3LYP and the semiempirical AM1 met
The present paper describes a rational analytical approach to a fire engineering design of load-bearing structures and partitions. The design method is permitted to be generally applied in Sweden, as one alternative, since about ten years. The method is directly based on the natural fire concept and strictly defined functional requirements and performance criteria . For facilitating the practical
This work presents a literature review and a questionnaire study with 62 participants aimed at providing recommendations on the design of a set of evacuation systems for road tunnels: 1) Traffic Information Sign (TIS) - message and size of the sign (large or small), colour scheme, and use of pictograms and/or flashing lights, 2) Emergency exit portal layout - colour scheme, 3) Acoustic systems - v
Background: The landlocked mountain country of Nepal has an extreme topography and is one of the poorest and least developed countries in the world. Nepal has ratified and signed the Convention on the Rights of Persons with Disabilities (CRPD). To understand what is required to improve prosthetic provision and services for persons living with an amputation in low-income countries, it is of interes
Recent scholarly work has enhanced our understanding of how new path development activities are enabled or constrained by ‘regional environments’, made up of pre-existing industrial structures, knowledge organizations, support structures and institutional configurations. This paper moves beyond overly static views on regional environments. We develop a dynamic perspective by analysing conceptually
The computing grid is a distributed parallel processing system that share and choosing resources dynamically and provide need of user operation power, cost and quality .grid management resources does as a diagnostic and assigning resources scheduling and resource monitoring in grid . Scheduling process directs tasks to suitable resources. It must take place some how that load work distributed equa
Presented at conference on NGO studies and anthropology, panel on elite NGOs and NGO elites. Abstract. The anticorruption NGO Transparency International was founded in 1993 by a former World Bank official and his network of ex-diplomats, lawyers, development consultants and businessmen. With headquarters in Berlin and affiliate organizations in 90 countries, it is truly one of the most successful
We have used DNA microarrays to survey rates of mRNA decay on a genomic scale in early stationary-phase cultures of Bacillus subtilis. The decay rates for mRNAs corresponding to about 1500 genes could be estimated. About 80% of these mRNAs had a half-life of less than 7 min. More than 30 mRNAs, including both mono- and polycistronic transcripts, were found to be extremely stable, i.e. to have a ha
