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Derivatives of N-acetyllactosamine carrying structurally diverse thioureido groups at galactose C3 were prepared from a C3'-azido N-acetyllactosamine derivative in a three-step reaction sequence involving azide reduction and isothiocyanate formation by thiophosgene treatment of the C3-amine, followed by reaction of the isothiocyanate with a panel of amines. Evaluation of the N-acetyllactosamine th
Huntington's disease is an autosomal dominant disease which presents with striatal and cortical degeneration causing involuntary movements, dementia and emotional changes. We employed 16-week-old transgenic Huntington mice (R6/1 line developed by Bates and coworkers) that express exon 1 of the mutant human Huntington gene with 115 CAG triplet repeats. At this age, R6/1 mice do not exhibit an overt
A two-phase hollow-fiber (HF) liquid-phase microextraction (LPME) method was developed for determination of a quaternary ammonium compound surfactant, dicocodimethylammonium chloride, in aqueous samples. The porous HF was fixed on a metal rod support and was impregnated with approximately 6.6 mu L of organic extractant, which was immobilized in the HF pores. Surfactant extraction was facilitated b
PURPOSE: This study describes the quality of life (QOL) and uncertainty in patients who have an l implantable cardioverter defibrillator (ICD) and predicts QOL at long-term follow-up. METHODS: Long-term follow-up was defined as 6.9 years 1 year (range 4.11-8.7 years). QOL was measured with the Quality of Life Index, and uncertainty was measured with the Mishel Uncertainty in Illness Scale. RESULTS
The present paper presents a rational expression for the initiation of motion for non-cohesive sediment under rough turbulent wave conditions. Previously proposed relationships for the initiation of motion are examined as well as laboratory measurements corresponding to fully rough turbulent boundary layers (which is normally the case under prototype conditions). By combining the modified Shields
The Swedish Program "Leadership, Organization and Communication" (LOM) was a research and a development program designed to support local processes of change in the private and the public sector. The program was carried out between 1985 and 1990. The strategy of LOM was focused on two basic principles: the principle of democratic dialogue and the principle of development of a "communicative infras
Literature on socio-technical transitions has primarily emphasized the co-determination of institutions and technologies. In this paper, we want to focus on how actors play a mediating role between these two pillars of a socio-technical system. By introducing the theoretical concept of institutional work, we contribute to the conceptualization and empirical assessment of agency processes in socio-
The public sphere and public reason have recently become key ideas in global governance, with most scholars expressing related transparency and accountability concerns. This article contends that if transnational public sphere(s) and the use of reason in global policy-making aim to reinforce the common good and justice, they must go beyond the procedural concerns of transparency and accountability
Background: Teachers are at high risk of stress-related disorders. This study aimed to examine the occurrence of burnout in a sample of Swedish school-teachers, to test a combined measure of three burnout dimensions on the individual level, to characterize associations between burnout and factors encountered during work and leisure time, and to explore any differences between the genders. Methods:
A maximum likelihood methodology for a general class of models is presented, using an approximate Bayesian computation (ABC) approach. The typical target of ABC methods are models with intractable likelihoods, and we combine an ABC-MCMC sampler with so-called "data cloning" for maximum likelihood estimation. Accuracy of ABC methods relies on the use of a small threshold value for comparing simulat
Plant species sometimes perform extraordinarily well when introduced to new environments, through achieving higher growth rates, individual biomasses or higher densities in their receiving communities compared to their native range communities. One hypothesis proposed to explain enhanced performance in species’ new environments is that their soil microbial communities may be different and provide
In modern manufacturing the production safety is often the key factor to achieve good product quality. Factors that influence the production safety are many, durability of machining centres, electric power supply and also the tool life. The tool life is governed by the ability to resist wear and failure. The long term wear is usually easy to predict contrary to premature failure. Premature failure
Context. Development of safety-critical systems is mostly governed by process-heavy paradigms, while increasing demands on flexibility and agility also reach this domain. Objectives. We wanted to explore in more detail the industrial needs and challenges when facing this trend. Method. We launched a qualitative survey, interviewing engineers from four companies in four different industry domains.
Control of the solids content after vacuum dewatering is vital for efficient control and energy use of the paper machine. Dewatering is a complex function of many parameters such as fibre and pulp properties as well as settings on the paper machine and a predictive model for dewatering will require extensive and detailed studies of the occurring physical phenomena. The hypothesis investigated in t
The focus of this paper is to derive the symbol error probability (SEP) of a Rake receiver with a limited number of fingers that track the strongest multipath components in a frequency-selective Rayleigh fading channel. We develop an analytical framework that allows the computation of the SEP for nonuniform power dispersion profiles (PDPs) and spreading bandwidth. By transforming the physical Rake
The demand for rare earth elements (REEs) is growing, while the future supply is uncertain. Their unique electronic characteristics make them irreplaceable, and the commercial value of pure fractions is high. A model-based simulation study is presented that compares batch chromatography with the twin-column MCSGP (multicolumn countercurrent solvent gradient purification) process for ion-exchange c
