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The Black Swan problem : The role of capital, liquidity and operating flexibility

How firms cope with tail risk is an under-researched problem in the literature on corporate risk management. This paper presents stylized facts on the nature of revenue shocks based on 65 years worth of Compustat data. We define a Black Swan as an unexpected year-on-year drop in revenue between 30%–90%. The rate of Black Swans has increased markedly since the 1970's and there are more pronounced c

Chemodiversity of Cyanobacterial Toxins Driven by Future Scenarios of Climate Warming and Eutrophication

Climate change and eutrophication are two environmental threats that can alter the structure of freshwater ecosystems and their service functions, but we know little about how ecosystem structure and function will evolve in future scenarios of climate warming. Therefore, we created different experimental climate scenarios, including present-day conditions, a 3.0 °C increase in mean temperature, an

What modulates telomere dynamics? : Inheritance, developmental effects, and physiological challenges

Telomeres are the conservative sequence repeats located at the end of linear chromosomes that have been the focus of intensive research across many disciplines over the last four decades. They function as a cap to protect the chromosome ends from fusion to other chromosomes and to prevent chromosome degradation. Telomere shortening is thought to be involved in ageing, reflecting or even causing ag

‘How do firms reach out to foreign universities? Inventors’ personal characteristics and the multinational structure of firms’

We analyze the determinants of firm-based inventors’ collaborations with universities abroad, comparing them with collaborations with national universities. We propose a micro-founded theoretical framework that introduces the role of personal linkages and global organizational pipelines as drivers of international academic collaborations, and we empirically investigate collaborations with national

Other syndromes of orthostatic intolerance : Delayed orthostatic hypotension, postprandial hypotension, postural orthostatic tachycardia syndrome, and reflex syncope

Apart from classical orthostatic hypotension, the gravitational force may strongly contribute to other forms of orthostatic intolerance, delayed and postprandial OH, postural orthostatic tachycardia syndrome (POTS), and reflex syncope. In delayed OH, the significant blood pressure drop occurs first after 3-min period of orthostasis, whereas in postprandial OH, the symptoms appear first approximate

Lignin recovery from cocoa bean shell using microwave-assisted extraction and deep eutectic solvents

Lignin is the second most abundant natural polymer after cellulose, and valorisation of lignin-rich streams has attracted increasing attention recently. This paper presents a novel and sustainable method to recover lignin from Cocoa Bean Shells (CBS) using Deep Eutectic Solvents (DES) and microwaves. A DES containing p-toluenesulfonic acid, choline chloride and glycerol (2:1:1 M ratio) was selecte

Constructing Regional Advantage in the Austrian ICT Sector-Towards Fine-Tuned Innovation Policies?

Regional innovation policies are often applied in a standardized way oriented at best practice models developed elsewhere. These policies fail to take specific sectoral and regional characteristics sufficiently into account. However, innovation processes and problems vary for firms in particular sectors since these exhibit distinct features dependent on their knowledge base. Also, companies are lo

End-to-End Estimation of Hand- and Wrist Forces From Raw Intramuscular EMG Signals Using LSTM Networks

Processing myoelectrical activity in the forearm has for long been considered a promising framework to allow transradial amputees to control motorized prostheses. In spite of expectations, contemporary muscle-computer interfaces built for this purpose typically fail to satisfy one or more important desiderata, such as accuracy, robustness, and/or naturalness of control, in part due to difficulties

Will the R in R&D at large technology corporations disappear? : The demise of the ‘R’ in corporate R&D: is academia stepping up to the challenge?

The author has as a practitioner in industry for 25 years seen a shift in the attitude to corporateresearch. Previously, most established technology firms had substantial departments doing research.Over the years this has changed, and corporate research not seen as short term profitable hasdecreased.A number of papers indicate that the amount of in-house science in technology corporations isindeed

Effect of polymorphism on in vitro-in vivo properties of carbamazepine conventional tablets

The objective of the present study was to investigate the effect of polymorphism on in vitro-in vivo properties of carbamazepine (CBZ). For this purpose, three different polymorphs and a dihydrate of CBZ were obtained and the conventional tablets of these crystalline forms at the dose of 200 mg were prepared. The polymorphs were examined by the IR and DSC analysis. The tablets were investigated by

Pickering emulsions based on CaCl2-gelatinized oat starch

The aim of this study was to investigate calcium chloride-induced gelatinization of oat starch, and its effects on the properties of oat starch-based Pickering emulsions. The starch granules were gelatinized in CaCl2 for up to 24 h and the results indicate that the salt-induced gelatinization of oat granules is not a surface phenomenon, as gelatinization and dissolution of the whole starch granule

Time Trends and Monthly Variation in Swedish Acute Stroke Care

Background and Purpose: Studies of monthly variation in acute stroke care have led to conflicting results. Our objective was to study monthly variation and longitudinal trends in quality of care and patient survival following acute stroke.Methods: Our nationwide study included all adult patients (≥18 years) with acute stroke (ischemic or hemorrhagic), admitted to Swedish hospitals from 2011 to 201

Graphene-based plasmonic nanocomposites for highly enhanced solar-driven photocatalytic activities

High-efficiency photocatalysts are crucial for the removal of organic pollutants and environmental sustainability. In the present work, we report on a new low-temperature hydrothermal chemical method, assisted by ultrasonication, to synthesize disruptive plasmonic ZnO/graphene/Ag/AgI nanocomposites for solar-driven photocatalysis. The plasmonic nanocomposites were investigated by a wide range of c

Educating sustainability change agents : The importance of practical skills and experience

Sustainability professionals are agents for change towards sustainable development. Such professionals require knowledge from a variety of disciplines, but also competencies to accomplish real-word change. This article evaluates an innovative course, Strategic Environmental Development, which immerses students in a real-life solution-oriented consultancy project in order to develop critical sustai

Cell-based cartilage repair : Do we need it, can we do it, is it good, can we prove it?

Adult human joint cartilage lesions do not spontaneously heal. Patients with isolated articular cartilage lesions make up perhaps some 1% of the total number of patients examined by arthroscopy. Symptoms such pain and locking, and the suggestion that the untreated lesions may progress to osteoarthritis form the basis for current attempts to repair articular cartilage by cell transplantation and ot

Atrial fibrillation patients with CHA2DS2-VASc > 1 benefit from oral anticoagulation prior to cardioversion

Background Electrical cardioversion of atrial fibrillation is associated with an increased risk of embolic stroke, but is generally considered safe if performed within 48 h after onset. Our objective was to investigate if thromboembolism and bleeding in association with cardioversion of atrial fibrillation differed between patients with and without oral anticoagulation. Methods Retrospective study

Low real-world early stent thrombosis rates in ST-elevation myocardial infarction patients and the use of bivalirudin, heparin alone or glycoprotein IIb/IIIa inhibitor treatment : A nationwide Swedish registry report

Background In recent studies of primary percutaneous coronary intervention (PCI), bivalirudin compared with heparin has been associated with increased risk of stent thrombosis (ST). Our aim was to describe incidence and outcome of definite, early ST in a large contemporary primary PCI population divided in antithrombotic therapy subgroups. Methods and Results A prospective, observational cohort st

Experimental analysis on filter press and energy consumption performance of diaphragm press drying device in chemical post-processing integrated equipment

Higher efficiency, lower energy consumption and less pollution are become more and more important in chemical engineering. Post-process is one of the key parts for producing chemical productions. Thus, we develop a novel device, Chemical Post-Processing Integrated Equipment (CPPIE), which can deal with crystallization, filtration, washing and drying in the same tank by changing the position of it.