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Bones are able to adapt their local density when exposed to mechanical loading. Such growth processes result in densification of the bone in regions of high loading levels and in resorption of the material in regions of low loading levels. This evolution and optimisation process generates heterogeneous distributions of bone density accompanied by pronounced anisotropic mechanical properties. While
Background: Environmental and genetic factors predispose an individual to the development of Graves' disease (GD). In an expression study of intraorbital tissue, adipocyte-related immediate early genes (IEGs) and immunomodulatory genes were found to be overexpressed in patients with Graves' ophthalmopathy (GO). We hypothesized that genetic variations in these genes could be associated with GD and/
Background The Project on Research and Intervention in Monotonous work (PRIM) studied Danish workers for 3-4years to determine the effects of monotonous work. The present study is a subset of that cohort and compares prevalence and incidence differences of carpal tunnel syndrome (CTS) between workers with highly repetitive work tasks and workers with varied work tasks. Methods The baseline study i
AIMS: To study the prospective relationship of blood pressure response during orthostatic challenge with incidence of heart failure (HF). METHODS AND RESULTS: In a Swedish prospective cohort study (the Malmö Preventive Project), we followed up 32 669 individuals (68.2% men; mean age, 46 years) over a period of 24 years. Incidence of first hospitalization due to new-onset HF was related to early (6
Popular Abstract in Swedish För att vi människor ska kunna upprätthålla balansen och utföra rörelser behöver vi ett komplext styrsystem som kontinuerligt kontrollerar och samordnar kroppens rörelser. Detta styrsystem, som kallas postural kontroll, får sin information från synen, balanssinnet (vestibularisorganen), led-muskelsinnet (proprioception) och receptorer i huden (mekanoreceptorer). Om någoThe ability to obtain correct balance control information and adjust motor performance appropriately are essential elements in effective postural control. However, functional disorders may affect the reliability of receptor information and ability to carry out corrective motions needed to maintain balance. This emphasizes the importance of rapid and accurate adaptation processes that can optimize
Satellite-derived Normalized Difference Vegetation Index (NDVI), a proxy of vegetation productivity, is known to be correlated with temperature in northern ecosystems. This relationship, however, may change over time following alternations in other environmental factors. Here we show that above 30°N, the strength of the relationship between the interannual variability of growing season NDVI and te
Background: Recent reviews conclude an association between traffic-related pollution and incidence of asthma in children, but not all studies agree. Studies have almost exclusively relied on parental-reported symptoms or parental-reported diagnoses of asthma and wheeze. Our aim was to investigate if traffic exposure is associated with higher incidence of early onset asthma, using registry-based ou
Background: The Toll-like receptor proteins are important in host defense and initiation of the innate and adaptive immune responses. A number of studies have identified associations between genetic variation in the Toll-like receptor genes and allergic disorders such as asthma and allergic rhinitis. The present study aim to search for genetic variation associated with allergic rhinitis in the Tol
Popular Abstract in Swedish Patienter med diabetes mellitus har högt blodsocker. Insulin reglerar blodsockervärdena. Redan i slutet av 1800 talet föreslogs att skulle det finnas två olika typer av diabetes, den ena beroende på bristande insulinbildning, den andra beroende på bristande insulineffekt. I början av 1900 talet utvecklades insulinframställningen. Observationer av blodsockernivåerna i blThe Diabetes Incidence Study in Sweden (DISS) registers diabetes in young adults aged 15-34 years in Sweden. This thesis aims to validate the ascertainment, methods in the classification of diabetes, and putative etiological factors such as family background, psychological stress, and BMI, that may affect the incidence of diabetes in young adults, in the DISS registry. The capture-recapture method
OBJECTIVE-Although insulin resistance (IR) may underlie associations between depressive symptoms and diabetes, previous findings have been contradictory. We examined whether depressive symptoms associate with IR and insulin secretion, and, additionally, whether antidepressant medication use may modulate such associations. RESEARCH DESIGN AND METHODS-A total of 4,419 individuals underwent an oral g
A series of bistridentate ruthenium(II) polypyridyl-type complexes based on the novel 2,6-di(quinolin-8-yl)pyridine (dqp) ligand have been synthesized and their photophysical properties have been studied. The complexes are amenable to substitution in the 4-position of the central pyridine with conserved quasi-C-2v symmetry, which allows for extension to isomer-free, rod-like molecular arrays for v
Rotational coherent anti-Stokes Raman spectroscopy (CARS) in fuel-rich hydrocarbon flames, with a large content of hydrogen in the product gases (similar to 20%), has in previous work shown that evaluated temperatures are raised several tens of Kelvin by taking newly derived N-2-H-2 Raman line widths into account. To validate these results, in this work calibrated temperature measurements at aroun
Background: Pancreatic cancer and other pancreaticobiliary type periampullary adenocarcinomas have a dismal prognosis even after resection and neoadjuvant chemotherapy. Intestinal type periampullary adenocarcinomas generally have a better prognosis, but little is known on optimal neoadjuvant and adjuvant treatment. New prognostic and treatment predictive biomarkers are needed for improved treatmen
Objectives To study regional cerebral blood perfusion with power Doppler ultrasound (PDU) imaging in appropriate-for-gestational age (AGA) fetuses and those with intrauterine growth restriction (IUGR) at different hemodynamic stages of fetal deterioration. Methods Brain blood perfusion was studied with PDU imaging, and the fractional moving blood volume (FMB V) was estimated in 56 growth-restricte
BACKGROUND: Job strain, defined as high job demands and low job control, has not previously been explored as a possible determinant of male fertility. We collected prospective data on job strain among men, and describe the associations with semen quality and probability of conceiving a clinical pregnancy during a menstrual cycle. METHODS: Danish couples (N = 399) who were trying to become pregnant
We have estimated the activation energy for hydrogen abstraction by compound I in cytochrome P450 for a diverse set of 24 small organic substrates using state-of-the-art density functional theory (B3LYP). We then show that these results can be reproduced by computationally less demanding methods, for example, by using small organic mimics of compound I with both B3LYP and the semiempirical AM1 met
Aims/hypothesis Post-translational modifications, such as isomerisation of native proteins, may create new antigenic epitopes and play a role in the development of the autoimmune response. Protein-L-isoaspartate (D-aspartate) O-methyltransferase (PIMT), encoded by the gene PCMT1, is an enzyme that recognises and repairs isomerised Asn and Asp residues in proteins. The aim of this study was to asse
During drying, timber distortion is a major defect mainly due to shrinkage anisotropy, differences in longitudinal shrinkage, and spiral grain. The distortion can be reduced by external restraint and use of appropriate kiln schedules. The research presented here is part of a project on the improvement of shape stability of Norway spruce by high-temperature drying. The effects of drying temperature
