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Aims/hypothesis. We assessed how the role of genes genetic causation in causing maturity-onset diabetes of the young (MODY) alters the response to an oral glucose tolerance test (OGTT). Methods. We studied OGTT in 362 MODY subjects, from seven European centres; 245 had glucokinase gene mutations and 117 had Hepatocyte Nuclear Factor-1 alpha (HNF-1alpha) gene mutations. Results. BMI and age were si
In recent years, there has been an increasing demand from manufacturing industries for new tool materials such as more wear resistant zinc-alloys, with optimised characteristics regarding short-run sheet-metal parts production. Research on zinc-alloys wear resistance has been performed by a lot of research groups. However, it is very difficult to compare the wear resistance of these materials due
Murine monoclonal antibodies (mAbs) which specifically react, in immunoblot and immunolocalization experiments, with the human desmosomal cadherins, desmocollins Dsc1 (mAb Dsc1-U100) and Dsc3 (mAb Dsc3-U114), have allowed to study systematically the synthesis of these proteins in tissues and cultured cells. Application of these mAbs in immunofluorescence microscopy on human skin has shown the pres
The review and Paper I present applications of economics to the use of alcohol. The review considers the demand for alcohol. The first paper also considers taxes and other alcohol policy measures, social costs and economic evaluations. In Paper II, an Almost Ideal Demand System Model is used for the study of the demand for alcoholic beverages in Sweden during the years 1985-1995. The results indi
The verification of the correctness of planned and executed treatments is imperative for safety in radiotherapy. The purpose of the present work is to describe and evaluate the quality assurance (QA) procedures for patient dosimetry implemented at the boron neutron capture therapy (BNCT) facility at Studsvik, Sweden. The dosimetric complexity of the mixed neutron-photon field during BNCT suggests
This book deals with ’have’ in ancient Greek. Two different types of ’have’-constructions were used, viz., on the one hand, the active transitive verb ἔχω and, on the other hand, the verb εἶναι, ’be’, with a complement in the dative case (here called the ἔστι μοι construction). A transitive ’have’ does not seem to be of Proto-Indo-European origin but rather an innovation in separate Indo-European
This case-control study based in Nordic serum banks evaluated the joint effects of infections with genital human papillomavirus (HPV) types, and Chlamydia trachomatis in the aetiology of cervical squamous cell carcinoma. Through a linkage with the cancer registries, 144 cases were identified and 420 controls matched to them. Exposure to past infections was defined by the presence of specific IgG a
AIMS: Studies indicate a poorer quality of life (QoL) for implantable cardioverter defibrillator (ICD) patients than for the general population. However, studies comparing the QoL of ICD patients with that of patients with other implantable cardiac devices are scarce. We hypothesized that ICD patients had a poorer QoL than pacemaker patients. METHODS AND RESULTS: All ICD patients living in Iceland
Malaria-induced sepsis is associated with an intense proinflammatory cytokinemia for which the underlying mechanisms are poorly understood. It has been demonstrated that experimental infection of humans with Plasmodium falciparum primes Toll-like receptor (TLR)-mediated proinflammatory responses. Nevertheless, the relevance of this phenomenon during natural infection and, more importantly, the mec
A global faunal crisis close to the Eifelian-Givetian stage boundary in the mid-Devonian has been purported to be related to the impact of one or two major extraterrestrial bodies. This was based on unusual mineralogical and chemical features within a distinct composite marl bed, at a level c. 40 cm below the Global Stratotype Section and Point (GSSP) for the Eifelian-Givetian boundary at Jebel Me
Nanotechnology is an evolving scientific field that has allowed the manufacturing of materials with novel physicochemical and biological properties, offering a wide spectrum of potential applications. Properties of nanoparticles that contribute to their usefulness include their markedly increased surface area in relation to mass, surface reactivity and insolubility, ability to agglomerate or chang
Objective: To build on Achenbach, Rescorla, and Ivanova (2012) by (a) reporting new international findings for parent, teacher, and self-ratings on the Child Behavior Checklist, Youth Self-Report, and Teacher's Report Form; (b) testing the fit of syndrome models to new data from 17 societies, including previously underrepresented regions; (c) testing effects of society gender, and age in 44 societ
CCR5-using (R5) human immunodeficiency virus type 1 (HIV-1) strains cause CD4+ T-cell loss in most infected individuals, but mechanisms underlying cytopathicity of R5 viruses are poorly understood. We investigated mechanisms contributing to R5 envelope glycoprotein (Env)-mediated cellular apoptosis by constructing a panel of retroviral vectors engineered to co-express GFP and R5 Envs derived from
Acta Geotechnica June 2013, Volume 8, Issue 3, pp 247-263 Localized deformation in intensely fissured clays studied by 2D digital image correlation C. Vitone, G. Viggiani, F. Cotecchia, S. A. Hall … show all 4 hide Citations 368 Downloads 200 Citations 9 Comments » Download PDF (3,181 KB) » View Article Abstract This paper represents a further step in a longstanding research on the influence
Background: Regional myocardial function is typically evaluated by visual assessment by experienced users, or by methods requiring substantial post processing time. Visual assessment is subjective and not quantitative. Therefore, the purpose of this study is to develop and validate a simple method to derive quantitative measures of regional wall function from velocity encoded Cardiovascular Magnet
Pseudomyogenic haemangioendothelioma (PHE) is an intermediate malignant vascular soft tissue tumour primarily affecting children and young adults. The molecular basis of this neoplasm is unknown. We here used chromosome banding analysis, fluorescence in situ hybridization (FISH), mRNA sequencing, RT-PCR and quantitative real-time PCR on a series of morphologically well-characterized PHEs to show t
Although cross-laminated timber (CLT) plates are increasingly used in high-performance building structures, a tailored composition of them or, at least, a performance-based classification scheme is not available. Especially, the influence of the quality of the ‘raw’ material (wooden boards) on the load carrying capacity of CLT elements is hardly investigated yet. For this reason, within this work,
