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Mutations within the DNA mismatch repair gene, "postmeiotic segregation increased 2" (PMS2), have been associated with a predisposition to hereditary nonpolyposis colorectal cancer (HNPCC; Lynch syndrome). The presence of a large family of highly homologous PMS2 pseudogenes has made previous attempts to sequence PMS2 very difficult. Here, we describe a novel method that utilizes long-range PCR as

Using the choroid plexus from pig a method has been developed to purify the epithelial cells from the underlying vascularized connective tissue stroma. An epithelial cell fraction was obtained that showed a purity of at least 95%, as determined by light microscopic analysis. The epithelial cells were investigated for the presence of binding sites for the neurotransmitter peptide, vasoactive intest

BACKGROUND: The aim of this study was to investigate how much perfusion pressure an artery can tolerate without significant loss of endothelium-dependent relaxation (EDR) and vascular contractility. METHODS: The abdominal aortas of 396 Sprague-Dawley rats were used. One hundred twenty aortas were flush-perfused for 1 or 5 minutes with cold St. Thomas' Hospital cardioplegic (STHC) solution or with

Challenges with an ageing population are increasingly becoming a reality in the Western world. Since cognitive impairment increases with age, we can expect an increasing number of older people in need of care. The aim of this article is to describe, analyse and compare different focuses on care of older people with dementia, using examples from France, Portugal and Sweden. The questions are princi

Our aim was to evaluate the severity of liver disease resulting from chronic hepatitis C in haemophilia or von Willebrand disease and the efficacy of 6 months treatment with interferon alpha and ribavirin. Fifty-five liver biopsies were performed in 43 patients without any bleeding complications, as seen with ultrasound immediately after the biopsy and 48 h thereafter. Histological changes were mi

Hypoglycaemia is presumed to be the cause of death in about 3% of insulin-treated diabetic patients. Some of these patients suffer from hypoglycaemic brain damage, but the majority have no evident brain damage and are supposed to have died from other causes such as a cardiac arrhythmia. The putative mechanism is a hypoglycaemia-induced prolongation of the QT interval which increases the risk of ma

Non-stretched laminar burning velocities, SL, of acetaldehyde + air mixtures at initial gas mixture temperatures, T, of 298, 318, 338, 348 and 358 K are reported for the first time. The flames were stabilized on a perforated plate burner at 1 atm using the heat flux method at conditions where the net heat loss from the flame to the burner is zero. Uncertainties of the measurements were analyzed an

The issue of possession of the air has been debated over literally thousands of years. The Romans debated the ownership of the air above their cornfields. When man finally could construct aircraft, in this case a balloon, heavier-than-air in the 1780's it did not take long before the first regulation came into force. The issue of state sovereignty had been discussed since the national states s

In this work, GaN/InGaN/GaN nanocolumns (NCs) have been grown by molecular beam epitaxy. Selective area growth (SAG) and self-organized growth (SOG) were performed simultaneously in patterned and unpatterned regions of the same substrate, respectively. The resulting structures show different tip morphologies and structural properties due to the different polarity along the growth direction, namely

Framväxten av digitala plattformar håller för närvarande på att förändra hur kulturarbete förmedlas och utförs. Trots detta finns det en brist på forskning, inte minst i en svensk kontext, som studerar kulturarbete som ett typexempel på det som kommit att kallas gigarbete. Den här avhandlingen analyserar frilansande kulturarbetares erfarenheter av att navigera den digitala plattformsekonomin för aCultural industries are currently being transformed by processes of platformization and precarization. Despite being among the sectors where platformization has already had the most pronounced effects, there remains a lack of research on cultural work as a prototypical example of so-called gig work. This dissertation analyzes the working experiences of what I call digital freelancers — solo self-e

The purpose of this essay was to examine how girls in the years of 17- 18 experience the differences between being a teenager or a young adult. In my attempts to find out what the girls believed themselves to be I have used the following questions; · How did the girls experience themselves, as teenager or as young adult? · What did the girls considered about the differences being a teenager or bei

BACKGROUND: Hyperglycemia is a risk factor for postoperative complications but its impact on outcome after pancreatoduodenectomy (PD) is scarcely studied. This prospective cohort study aimed to assess the effect of continuous insulin infusion on postoperative complications and blood glucose, as well as to evaluate the impact of hyperglycemia on complications, after PD. MATERIALS AND METHODS: One h

Bakgrund: Statistik från 2018 visar att cirka 45 % av sjukskrivningar i Sverige är relaterade till psykisk ohälsa. Anställda inom kontaktyrken är en särskilt utsatt grupp där även arbetsterapeuter ingår, vilket gör det intressant att undersöka hur denna grupp upplever sin psykosociala arbetsmiljö. Syfte: Att kartlägga hur arbetsterapeuter upplever sin psykosociala arbetsmiljö samt arbetstillfredss

We present a superconducting cavity-coupled double quantum dot (DQD) photodiode that achieves a maximum photon-to-electron conversion efficiency of 25% in the microwave domain. With a higher-quality-factor cavity and improved device design to prevent photon leakages through unwanted pathways, our device measures microwave signals down to the 100-aW power level and achieves sensitivity to probe mic

Today, youth crime is a topic that recurs daily in the news and politics; the subject arouses motions both within the professional community and among private individuals. The purpose of this study was to shed light on how social workers reason and work with young people aged 15 and above who are in criminal environments. We also shed light on how motivation can contribute to young people acceptin

Microsoft Word - ASG Rapid brain change and long term outcomes 2019-2019 ENG.docx ASG Rapid brain change and long- term outcomes We continue to learn new skills and develop our abilities throughout our life. Modern neuroimaging methods let us look inside the brain and observe how and where changes occur as an effect of experience. In the recent past, researchers have come to realize that learning

https://www.pi.lu.se/en/sites/pi.lu.se.en/files/asg_rapid_brain_change_and_long_term_outcomes_2019-2019_eng.pdf - 2026-05-20